한국자원식물학회지 (Korean Journal of Plant Resources)

  • 제23권6호
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  • Pages.498-502
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  • 2010
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  • 1226-3591(pISSN)
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  • 2287-8203(eISSN)
한국자원식물학회 (The Plant Resources Society of Korea)
권호 표지

Effects of $\beta$-glucans from Coriolus versicolor on Macrophage Functions in Young and Aged mice

  • Jang, Seon-A (Department of Herbal Medicine Resource, Kangwon National University) ;
  • NamKoong, Seung (Department of Physical Therapy, Kangwon National University) ;
  • Sohn, Eun-Hwa ( Department of Herbal Medicine Resource, Kangwon National University)
  • 투고 : 2010.06.03
  • 심사 : 2010.12.07
  • 발행 : 2010.12.31
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초록

The immune system may play an important role in aging and the changes in the immune status are associated with treatment of various immunomodulators. This study examined the effects of $\beta$-glucans isolated from mushroom fungi, Coriolus versicolor on macrophages functions in young (8-weeks-old) and aged (82-weeks-old) male C57BL/6 mice. When peritoneal macrophages were treated with various concentrations of $\beta$-glucan ($1-100\;{\mu}g/ml$) for 24 hrs, tumoricidal activity, NO production and phagocytic activity were significantly increased in the young mice, whereas there are no effects in the aged mice. These results suggest that $\beta$-glucans has differential effects on the macrophage functions in young and aged mice and age nutrition might need to be considered to select proper immunomodulator. In addition, $\beta$-glucan could be used clinically for the treatment of diseases such as cancer therapy in the young.

키워드

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