Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)
- Volume 42 Issue 3
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- Pages.149-154
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- 2010
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- 1738-3544(pISSN)
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- 2288-1662(eISSN)
Quality Improvements of Breast Specimen Fixation for Histopathology Test
병리검사를 위한 유방검체 고정의 질 향상 활동
- Cho, Seong-Il (Department of Pathology, Samsung Medical Center) ;
- Choi, Myung-Sup (Department of Pathology, Samsung Medical Center) ;
- Bae, Moon-Hwan (Department of Pathology, Samsung Medical Center) ;
- Lee, Moon-Jung (Department of Pathology, Samsung Medical Center) ;
- Woo, Hee-Suck (Department of Pathology, Samsung Medical Center) ;
- Park, Soon-Chae (Graduate School of Business, Yonsei University) ;
- Cho, Eun-Yoon (Department of Pathology, Samsung Medical Center)
- 조승일 (삼성서울병원 병리과) ;
- 최명섭 (삼성서울병원 병리과) ;
- 배문환 (삼성서울병원 병리과) ;
- 이문정 (삼성서울병원 병리과) ;
- 우희숙 (삼성서울병원 병리과) ;
- 박순채 (연세대학교 경영전문대학원) ;
- 조은윤 (삼성서울병원 병리과)
- Received : 2010.10.28
- Accepted : 2010.12.23
- Published : 2010.12.30
Abstract
To improve accuracy of the immunohistochemical testing and fluorescence in situ hybridization (FISH) study as well as a routine histology diagnosis in breast cancer, quality improvement for optimal tissue handling is mandatory. We evaluate fraction defective of 7107 blocks from 349 breast cancer patients, who underwent surgical treatment at Samsung Medical Center Seoul, Korea from January 1, 2009 to March 31, 2010. We decided pre-improvement period from January, 2009 to June, 2009. In the first quality improvement period (July, 2009 to September, 2009) we made improvements in protocol of gross examination. In the second quality improvement period (October, 2009 to December, 2009) we attempted more effective formalin fixation such as frequent exchange of formalin and use of separate fixation container for each case. In the third quality improvement period (January, 2010 to March, 2010) improvement of tissue processor was performed. We achieved a marked reduction of fraction defective (9-16%) through efforts to improve quality of formalin-fixed, paraffin-embedded blocks when compared to pre-improvement period.