Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Increased Expression of MET and RON Receptor Tyrosine Kinases in Canine Cutaneous Melanotic Tumor

개 피부 흑색종의 MET/RON Receptor Tyrosine Kinases 발현 평가

  • Han, Jae-Ik (Veterinary Laboratory Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Dae-Yong (Laboratory of Veterinary Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Na, Ki-Jeong (Veterinary Laboratory Medicine, College of Veterinary Medicine, Chungbuk National University)
  • Published : 2009.10.31
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Abstract

Aberrant translocation of ${\beta}$-catenin can be induced by the dissociation of cadherin-catenin complex, which is mediated by the activation of receptor tyrosine kinases (RTKs). We examined the expression levels of MET/RON RTKs in tissue samples of canine cutaneous melanotic tumor. The activation of MET/RON RTKs was observed in 28% of the examined samples. Our results indicate the possibility that the activated MET/RON RTKs are implicated in the dissociation of cadherin-catenin complex in canine cutaneous melanotic tumor.

Cadherin-catenin 복합체의 파괴는 ${\beta}$-catenin 단백질의 발현 위치 이상(세포내 이동)을 유발하며, 일부 receptor tyrosine kinase (RTK)의 활성화가 cadherin-catenin 복합체의 파괴를 유발할 수 있다. 본 연구에서는 ${\beta}$-catenin의 발현 위치 이상을 나타낸 개 피부 흑색종 조직 18개에서 MET/RON RTKs의 발현양을 평가하였다. 실험 결과 총 28%의 종양조직에서 MET/RON RTKs의 발현증가가 관찰되었다. 이 결과는 개 피부 흑색종에서 MET/RON RTKs의 발현증가가 ${\beta}$-catenin의 위치이상에 부분적으로 관여할 가능성을 제시한다.

Keywords

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