Korean Journal of Ecology and Environment (생태와환경)

The Korean Society of Limnology (한국수생태학회)
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Evaluation of the Potential Human Health Risk Associated with the Microcystin Bioaccumulation in the Freshwater Fish from Lake Yeongcheon and Lake Daecheong

영천호와 대청호에서 담수어류의 microcystin 농축에 따른 인체 건강위해성 평가

  • Lee, Kyung-Lak (Department of Forenscic Medicine, National Institute of Scientific Investigation) ;
  • Jheong, Weon-Hwa (Department of Biology, Kyungpook National University) ;
  • Kang, Young-Hoon (Department of Biology, Kyungpook National University) ;
  • Kim, Han-Soon (Department of Biology, Kyungpook National University)
  • 이경락 (국립과학수사연구소 법의학과) ;
  • 정원화 (국립환경과학원 먹는물연구과) ;
  • 강영훈 (경북대학교 생물학과) ;
  • 김한순 (경북대학교 생물학과)
  • Published : 2009.09.30
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Abstract

This study evaluated the potential human health risk on the basis of the level of bioaccumulation and EDI (Estimated Daily Intake) of microcystin-LR, one of hepatotoxic, in organs, including liver, muscle, viscera and gill, of fish from Lake Yeongeheon and Lake Daecheong when the cyanobacterial water-blooms broke out. The result has confirmed that Carassius cuvieri from Lake Yeongcheon contains higher level of microcystin-LR in its organs including liver. In Lake Daecheong, omnivorous Hemibarbus labeo and phytoplanktivorous Carassius cuvieri have shown high microcystin-LR level on average, especially higher for viscera, and Carassius cuvieri has appeared to contain higher level of microcystin-LR in the liver and the gill compared with other species. As a result of comparison between EDI of microcystin-LR from each organs and TDI (Tolerable Daily Intake) of WHO (Chorus and Bartram, 1999) to evaluate human health risk, the EDI levels from Carassius cuvieri's organs except museles have exceeded TDI level at the both lakes. Consequently, the study has proved that microcystin was bioaccumulated in the various parts of fish, and it can be ingested by human resulting in risking human health. Continuous monitoring and reducing consumption of fish, especially Carassius cuvieri, during the cyanobacterial water-blooming period will be needed to protect human health.

영천호와 대청호 어류들의 각 조직들(근육, 간, 내장, 아가미)에 농축된 microcystin-LR의 농도 및 TDI(total daily intake)값에 기초하여 인체의 건강위해성을 평가하였다 영천호의 분석결과에서 조식성(藻飾性)인 떡붕어(Carassius cuvieri)는 다른 종들과 비교하여 간을 포함한 대부분의 조직에서 높은 microcystin-LR의 농축양상을 보였다. 대청호에서 잡식성(雜食性)인 누치와 조식성인 떡붕어의 각 조직에서 높은 microcystin-LR 농도가 관찰된 가운데 내장에서는 누치와 떡붕어가 매우 높은 microcystin-LR 농도를 보였으며, 떡붕어는 다른 종들과 비교하여 내장이외에도 간과 아가미에서 높은 microcystin-LR농도를 나타내었다. 인체의 건강위해성 평가를 위해 각 조직에서 도출된 microcystin-LR의 EDI(estimated daily intake) 값들을 TDI 값과 비교하였다. 결과에서, 두 조사지역에서 모두 떡붕어(Carassius cuvieri)는 근육을 제외한 대부분의 조직들에서 EDI값들이 TDI 값을 초과하는 양상을 보였다.

Keywords

References

  1. 국립환경과학원. 2005. 2005년도 조류예보제 시행결과보고서. 국립환경과학원, 인천
  2. 이경락, 정원화, 김종민, 김영생, 최희진, 김한순. 2008. 영천호에서 남조류독소(microcystins)의 계절적 변동. 한국하천호수학회지 41: 264-274
  3. 최기철, 전상린, 김익수, 손영목. 1990. 원색한국담수어도감. 향문사
  4. Chorus, I. and J. Bartram. 1999. Toxic Cyanobacteria in Water: A Guide to Their Public Health Consequences, Monitoring, and Management. SPON Press, on behalf of the World Health Organization
  5. Craig M., H.A. Luu, T.L. Mccready, D. Williams, RJ. Andersen and C.F.B. Holmes. 1996. Molecular mechanisms underlying the interaction of motuporin and microcystins with type-1 and type-2A protein phosphatases. Bioehem. Cell Biol. 74: 569-578 https://doi.org/10.1139/o96-061
  6. Dietrich, D. and S. Hoeger. 2005. Guidance values for microcystins in water and cyanobacterial supplement products (blue-green algal supplements): a reasonable or misguided approach? Toxicol. Appl. Pharmacol. 203: 273-289 https://doi.org/10.1016/j.taap.2004.09.005
  7. Falconer, I. 1999. An review of problems caused by toxic blue-green algae (cyanobacteria) in drinking water. Environ. Toxieol. 14: 5-12 https://doi.org/10.1002/(SICI)1522-7278(199902)14:1<5::AID-TOX3>3.0.CO;2-0
  8. Fastner, J., U. Neumann, B. Wirsing, J. Weckesser, C. Wiedner, B. Nixdorf and I. Chorus. 1999. Microcystins (Hepatotoxic heptapeptides) in German fresh water bodies. Environ. Toxieol. 14: 13-22 https://doi.org/10.1002/(SICI)1522-7278(199902)14:1<13::AID-TOX4>3.0.CO;2-D
  9. Fawell, J.K, C.P. James and H.A James. 1994. Toxins from blue-green algae: Toxicological assessment of microcystin-LR and a method for its determination in water. Water Research Centre, Medmenham
  10. Fischer, W.J. and D.R Dietrich. 2000. Pathological and biochemical characterization of microcystin-induced hepatopancreas and kidney damage in carp (Cyprinus carpio). Toxieol. Appl. Pharmaeol. 164: 73-81 https://doi.org/10.1006/taap.1999.8861
  11. Gkelis, S., T. Lanaras and S. Sivonen. 2006. The presence of microcystins and other cyanobacterial bioactive peptides in aquatic fauna collected from Greek freshwaters. Aqua. Toxieol. 10: 32-41 https://doi.org/10.1016/j.aquatox.2006.02.001
  12. Harada, K-I., K Tsuji, M.F. Watanabe and F. Kondo. 1996. Stability of microcystins from cyanobacteria. III. Effect of pH and temperature. Phyeologia 35: 83-88
  13. Honkanen, RE., J. Zwiller, RE. Moore, S.L. Daily, B.S. Khatra, M. Dukelow and AL. Boynton 1990. Characterization ofmicrocystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases. J. Biol. Chem. 265: 19401-19404
  14. Ibelings, B.W. and I. Chorus. 2007. Accumulation of cyanobacterial toxins in freshwater "seafood" and its consequences for public health: A review. Environ. Pollut. 150: 177-192
  15. MacKintosh, C., KA Beattie, S. Klumpp, P. Cohen and G.A. Codd. 1990. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett. 264: 187-192 https://doi.org/10.1016/0014-5793(90)80245-E
  16. Magalhiies, V.F., RM. Soares and S.M.F.O. Azevedo. 2001. Microcystin contamination in fish from the Jacarepagua Lagoon (Rio de Janeiro, Brazil): ecological implication and human health risk. Toxieon 39: 1077-1108
  17. Magalhiies, V.F., M.M. Marino, P. Domingos, AC. Oliveira, S.M. Costa, L.O. Azevedo and S.M.F.O. Azevedo. 2003. Microcystins (cyanobacteria hepatotoxins) bioaccumulation in fish and crustaceans from Sepetiba Bay (Brasil, RJ). Toxieon 42: 289-295
  18. Mohamed, Z.A, W.W. Carmichael and AA Hussein. 2003. Estimation of microcystins in the freshwater fish Oreoehromis nilotieus in an Egyptian fish farm containing a Mieroeystis bloom. Environ. Toxieol. 18: 137-141 https://doi.org/10.1002/tox.10111
  19. Oh, H.-M., S.J. Lee, J.-H. Kim, H.-S. Kim and B.-D. Yoon. 2001. Seasonal variation and indirect monitoring of microcystin concentration in Daechung Reservoir, Korea. Appl. Environ. Mierobiol. 67: 1484-1489
  20. Preussel, K., A. Stuken, C. Wiedner, I. Chorus and J. Fastnero 2006. First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes. Toxieon 47: 156-162
  21. Ressom, R., F.S. Soong, J. Fitzgerald, L. Turczynowicz, O. El Saadi, D. Roder, T. Maynard and I. Falconer. 1994. Health effects of toxic cyanobacteria (blue-green algae), National Health and Medical Research Council, Australia
  22. Sivonen, K. and J. Jones. 1999. Cyanobacterial toxins. p. 41-112. In: Toxic cyanobacteria in water. A guide to their public health consequences, monitoring and management (Chorus I. and J. Bartram, eds.). World Health Organization, Geneva
  23. Watzin, M.C., E.B. Miller, A.D. Shambaugh and M.A. Kreider. 2006. Application of the WHO alert level framework to cyanobacterial monitoring of Lake Champlain, Vermont. Environ. Toxieol. 21: 278-288 https://doi.org/10.1002/tox.20181
  24. WHO. 1998. Guidelines for drinking water quality, 2nd edition. Addendum to volume 2. Health criteria and other supporting information, World Health Organization, Geneva
  25. Wilson, A.E., D.C. Gossiaux, T.O. HooK, J.P. Berry, P.F. Landrum, J. Dyble and S.J. Guildford. 2008. Evaluation of the human health threat associated with the hepatotoxin microcystin in the muscle and liver tissues of yellow perch (Perea flaveseens). Can. J. Fish Aquat. Sci. 65: 1487-1497 https://doi.org/10.1139/F08-067
  26. Xie, L.Q., P. Xie, L.G. Guo, L. Li, Y. Miyavara and H.-D. Park. 2005. Organ distribution and bioaccumulation of microcystins in freshwater fish at different trophic levels from the eutrophic Lake Chaohu, China. Environ. Toxieol. 20: 293-300 https://doi.org/10.1002/tox.20120
  27. Zhang, D., P. Xie, Y. Liu and T. Qiu. 2008. Transfer, distribution and bioaccumulation of microcystins in the aquatic food web in Lake Taihu, China, with potential risks to human health. Sci. Total Environ. 407: 2191-2199