Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

THE EFFECT OF RESORBABLE MEMBRANE ON BONE REGENERATION IN CALVARIAL DEFECTS OF RATS

백서의 두개골 결손부에서 탈단백우골 이식 시 흡수성악의 효과

  • Park, Young-Jun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institutue, Chonnam National University, 2nd stage of Brain Korea) ;
  • Choi, Guen-Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institutue, Chonnam National University, 2nd stage of Brain Korea) ;
  • Jang, Jung-Rok (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institutue, Chonnam National University, 2nd stage of Brain Korea) ;
  • Jung, Seung-Gon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institutue, Chonnam National University, 2nd stage of Brain Korea) ;
  • Kim, Young-Joon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institutue, Chonnam National University, 2nd stage of Brain Korea) ;
  • Yu, Min-Gi (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institutue, Chonnam National University, 2nd stage of Brain Korea) ;
  • Kook, Min-Suk (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institutue, Chonnam National University, 2nd stage of Brain Korea) ;
  • Oh, Hee-Kyun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institutue, Chonnam National University, 2nd stage of Brain Korea) ;
  • Ryu, Sun-Youl (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institutue, Chonnam National University, 2nd stage of Brain Korea) ;
  • Park, Hong-Ju (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institutue, Chonnam National University, 2nd stage of Brain Korea)
  • 박영준 (전남대학교 치의 학전문대학원 구강악안면외과학교실, 치의학연구소, 2단계 BK21) ;
  • 최근호 (전남대학교 치의 학전문대학원 구강악안면외과학교실, 치의학연구소, 2단계 BK21) ;
  • 장정록 (전남대학교 치의 학전문대학원 구강악안면외과학교실, 치의학연구소, 2단계 BK21) ;
  • 정승곤 (전남대학교 치의 학전문대학원 구강악안면외과학교실, 치의학연구소, 2단계 BK21) ;
  • 김영준 (전남대학교 치의 학전문대학원 구강악안면외과학교실, 치의학연구소, 2단계 BK21) ;
  • 유민기 (전남대학교 치의 학전문대학원 구강악안면외과학교실, 치의학연구소, 2단계 BK21) ;
  • 국민석 (전남대학교 치의 학전문대학원 구강악안면외과학교실, 치의학연구소, 2단계 BK21) ;
  • 오희균 (전남대학교 치의 학전문대학원 구강악안면외과학교실, 치의학연구소, 2단계 BK21) ;
  • 유선열 (전남대학교 치의 학전문대학원 구강악안면외과학교실, 치의학연구소, 2단계 BK21) ;
  • 박홍주 (전남대학교 치의 학전문대학원 구강악안면외과학교실, 치의학연구소, 2단계 BK21)
  • Published : 2009.09.30
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Abstract

Purpose : This research evaluates the effect of the use of absorbable membrane barrier with deproteinized bovine bone (Bio-$Oss^{(R)}$, Switzerland) on bone healing in surgically created critical-sized defects in rat calvaria. Materials and Methods : Two standardized transosseous circular calvarial defects (5 mm in diameter) are made in each calvarium of 30 rats. These rats are divided into negative control group(n=15), positive control group(n=15) and two experimental groups(n=15). In the negative control group, defects are only filled with blood clots. In the positive control group, defects are filled with autogenous bone obtained from calvarium; in the experimental group 1, defects are filled with deproteinized bovine bone; and in the experimental group 2, defects are filled with deproteinized bovine bone with absorbable membrane. At the postoperative 1 week, 3 weeks. and 6 weeks, clinical. histologic and histomorphometric evaluations of the defects are performed. Results : 1. The grafted bone without membrane in the calvarial bone defect was scattered but, the grafted bone with membrane was stable. 2. $BioMesh^{(R)}$ membrane was absorbed beginning at 3 weeks, and was absorbed considerably at 6 weeks while maintaining the structural form of the membrane. 3. The use of membrane blocked soft tissue invasion. 4. In histomorphometric analysis. it showed the greatest amount of new bone formation in the positive control group. The amount of new bone formation was greater in the experimental group 2 than experimental group 1. At 6 weeks. the amount of new bone formation was greater in the positive control group than experimental group l(p<0.005). Conclusion : These results suggest that membrane increase the stability of grafted bone and protects from soft tissue invasion, and the use of the membrane may promote new bone formation in deproteinized bovine bone graft area.

Keywords

References

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