Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Carboxylesterases: Structure, Function and Polymorphism

  • Satoh, Tetsuo (Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, and HAB Research Laboratory, Ichikawa General Hospital) ;
  • Hosokawa, Masakiyo (Laboratory of Drug Metabolism and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba Institute of Science)
  • Published : 2009.10.31
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Abstract

This review covers current developments in molecular-based studies of the structure and function of carboxylesterases. To allay the confusion of the classic classification of carboxylesterase isozymes, we have proposed a novel nomenclature and classification of mammalian carboxylesterases on the basis of molecular properties. In addition, mechanisms of regulation of gene expression of carboxylesterases by xenobiotics, and involvement of carboxylesterase in drug metabolism are also described.

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References

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