Food Science and Biotechnology

  • 제18권4호
  • /
  • Pages.904-909
  • /
  • 2009
  • /
  • 1226-7708(pISSN)
  • /
  • 2092-6456(eISSN)
한국식품과학회 (Korean Society of Food Science and Technology)
권호 표지

Synergistic Antioxidant Effects of Lycopene and Other Antioxidants on Methyl Linoleate Autooxidation

  • Shim, Youn-Young (Department of Food Science, University of Guelph) ;
  • Kakuda, Yukio (Department of Food Science, University of Guelph) ;
  • Shi, John (The Food Research Program, Agriculture and Agri-Food Canada)
  • 발행 : 2009.08.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The beneficial effects derived from consuming natural antioxidants may not depend on the action of an individual antioxidant, but rather on the concerted action of several antioxidants naturally present. The aim of this study was to determine the concentrations and combinations of antioxidants that can produce synergistic effects (SyEs). Quantification of the lipoperoxyl radical scavenging capacity of antioxidants was carried out in a homogeneous model system where the free radicals were produced by the oxidation of methyl linoleate, initiated by the 2,2'-azobis (2,4-dimethylvaleronitrile). The greatest SyE (2.21, p<0.05) was seen in mixtures of all 4 antioxidants when used with concentrations of 15 ${\mu}M$ lycopene, 2.5 ${\mu}M$ vitamin E, 0.16 ${\mu}M$ vitamin C, and 10 ${\mu}M$ ${\beta}-carotene$. Doubling the vitamin E concentration from 2.5 to 5.0 ${\mu}M$ in the mixture with all 4 antioxidant reduced the SyE to 1.69 (p<0.05). Other combinations produced synergistic effects that ranged from 1.28 to 1.41.

키워드

참고문헌

  1. Shi J, Kakuda Y, Yeung D. Antioxidative properties of lycopene and other carotenoids from tomatoes: Synergistic effects. BioFactors 21: 203-210 (2004) https://doi.org/10.1002/biof.552210141
  2. Klipstein-Grobusch K, Launer LJ, Geleijnse JM, Boeing H, Hofman A, Witteman JCM. Serum carotenoids and atherosclerosis: The Rotterdam study. Atherosclerosis 148: 49-56 (2000) https://doi.org/10.1016/S0021-9150(99)00221-X
  3. Rao AV, Agarwal S. Role of antioxidant lycopene in cancer and heart disease. J. Am. Coll. Nutr. 19: 563-569 (2000) https://doi.org/10.1080/07315724.2000.10718953
  4. Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. Intake of carotenoids and retinol in relation to risk of prostate cancer. J. Natl. Cancer I. 87: 1767-1776 (1995) https://doi.org/10.1093/jnci/87.23.1767
  5. Anguelova T, Warthesen J. Degradation of lycopene, $\alpha$-carotene, and TEX>$\beta$-carotene during lipid peroxidation. J. Food Sci. 65: 71-75 (2000) https://doi.org/10.1111/j.1365-2621.2000.tb15958.x
  6. Palozza P, Krinsky NI. TEX>$\beta$-Carotene and vitamin E are synergistic antioxidants. Arch. Biochem. Biophys. 297: 184-187 (1992) https://doi.org/10.1016/0003-9861(92)90658-J
  7. B$\"{o}$hm F, Edge R, Foley S, Lange L, Truscott TG. Antioxidant inhibition of porphyrin-induced cellular phototoxicity. J. Photoch. Photobio. B. 65: 177-183 (2001) https://doi.org/10.1016/S1011-1344(01)00259-7
  8. Stahl W, Junghans A, de Boer B, Drionina ES, Briviba K, Sies H. Carotenoid mixtures protect multilamellar liposomes against oxidative damage: Synergistic effects of lycopene and lutein. FEBS Lett. 427: 305-308 (1998) https://doi.org/10.1016/S0014-5793(98)00434-7
  9. Stratton SP, Liebler DC. Determination of singlet oxygenspecific versus radical-mediated lipid peroxidation in photosensitized oxidation of lipid bilayers: Effect of beta-carotene and alphatocopherol. Biochemistry 36: 12911-12920 (1997) https://doi.org/10.1021/bi9708646
  10. Biacs PA, Daood HG. Lipoxygenase-catalysed degradation of carotenoids from tomato in the presence of antioxidant vitamins. Biochem. Soc. T. 28: 839-845 (2000) https://doi.org/10.1042/BST0280839
  11. Terao J, Nagao A, Park D, Lim PB. Lipid hydroperoxide assay for antioxidant activity of carotenoids. Method Enzymol. 213: 454-460 (1992) https://doi.org/10.1016/0076-6879(92)13147-P
  12. Tesoriere L, Ciaccio M, Bongiorno A, Riccio A, Pintaudi AM, Liverea MA. Antioxidant activity of all-trans-retinol in homogeneous solution and in phosphatidylcholine liposomes. Arch. Biochem. Biophys. 307: 217-223 (1993) https://doi.org/10.1006/abbi.1993.1581
  13. Chan H, Levett G. Autoxidation of methyl linoleate. Separation and analysis of isomeric mixtures of methyl linoleate hydroperoxides and methyl hydroxylinoleates. Lipids 12: 99-104 (1977) https://doi.org/10.1007/BF02532979
  14. Fuhrman B, Volkova N, Rosenblat M, Aviram M. Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic. Antioxid. Redox Sign. 2: 491-506 (2000) https://doi.org/10.1089/15230860050192279
  15. Tsuchihashi H, Kigoshi M, Iwatsuki M, Niki E. Action of $\beta$-carotene as an antioxidant against lipid peroxidation. Arch. Biochem. Biophys. 323: 137-147 (1995) https://doi.org/10.1006/abbi.1995.0019
  16. Palozza P, Krinsky NI. The inhibition of radical-initiated peroxidation of microsomal lipids by both $\alpha$-tocopherol and $\beta$-carotene. Free Radical Bio. Med. 11: 407-414 (1991) https://doi.org/10.1016/0891-5849(91)90158-Y
  17. Niki E, Noguchi N, Tsuchihashi H, Gotoh N. Interaction among vitamin C, vitamin E, and $\beta$-carotene. Am. J. Clin. Nutr. 62: 1322S-1326S (1995) https://doi.org/10.1093/ajcn/62.6.1322S
  18. Burke M, Edge R, Land EJ, Truscott TG. Characterisation of carotenoid radilcal cations in liposomal environments: Interaction with vitamin C. J. Photoch. Photobio. B. 60: 1-6 (2001) https://doi.org/10.1016/S1011-1344(01)00111-7
  19. Mortensen A, Skibsted LH, Truscott TG. The interaction of dietary carotenoids with radical species. Arch. Biochem. Biophys. 385: 13-19 (2001) https://doi.org/10.1006/abbi.2000.2172
  20. Wrona M, Korytowski W, Rozanowska M, Sarna T, Truscott TG. Cooperation of antioxidants in protection against photosensitized oxidation. Free Radical Bio. Med. 35: 1319-1329 (2003) https://doi.org/10.1016/j.freeradbiomed.2003.07.005
  21. Aldini G, Yeum KJ, Carini M, Krinsky NI, Russell RM. (-)-Epigallocatechin-(3)-gallate prevents oxidative damage in both the aqueous and lipid compartments of human plasma. Biochem. Bioph. Res. Co. 302: 409-414 (2003) https://doi.org/10.1016/S0006-291X(03)00192-X
  22. Yeum KJ, Aldini G, Chung HY, Krinsky NI, Russell RM. The activities of antioxidant nutrients in human plasma depend on the localization of attacking radical species. J. Nutr. 133: 2688-2691 (2003) https://doi.org/10.1093/jn/133.8.2688