대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제30권4호
  • /
  • Pages.333-340
  • /
  • 2009
  • /
  • 1229-0807(pISSN)
  • /
  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
권호 표지
DOI QR코드

DOI QR Code

초고주파 가열치료를 위한 MR 호환 동축 슬롯 안테나의 개발

Development of MR Compatible Coaxial-slot Antenna for Microwave Hyperthermia

  • 김태형 (인제대학교 의생명공학대학 의용공학과) ;
  • 천송이 (인제대학교 의생명공학대학 의용공학과) ;
  • 한용희 (인제대학교 의생명공학대학 의용공학과) ;
  • 김동혁 (인제대학교 의생명공학대학 의용공학과) ;
  • 문치웅 (인제대학교 의생명공학대학 의용공학과)
  • Kim, T.H. (Department of Biomedical Engineering, Inje University) ;
  • Chun, S.I. (Department of Biomedical Engineering, Inje University) ;
  • Han, Y.H. (Department of Biomedical Engineering, Inje University) ;
  • Kim, D.H. (Department of Biomedical Engineering, Inje University) ;
  • Mun, C.W. (Department of Biomedical Engineering, Inje University)
  • 발행 : 2009.08.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

MR compatible coaxial-slot antenna for microwave hyperthermia was developed while its structure and size of each part were determined by computer simulation using finite element method(FEM). Its local heating performance was evaluated using tissue-mimic phantom and swine muscles. 2% agarose gel mixed with 6mM/$\ell$ $MnCl_2$ as a biological tissue-mimic phantom was heated by the proposed antenna driven by a 2.45GHz microwave generator. The temperature changes of the phantom were monitored using multi-channel digital thermometer at the distance of 0mm, 5mm, 10mm and 20mm from the tip center of the antenna. Also muscle tissue of swine was heated for 2 and 5minutes with 50W and 30W of microwave generator powers, respectively, to evaluate the local heating performance of the antenna. MRI compatibility was also verified by acquiring MR images and MR temperature map. MR signals were acquired from the agarose gel phantom using $T2^*$ GRE sequence with 1.5T clinical MRI scanner(Signa Echospeed, GE, Milwaukee, WI, U.S.A.) at Pusan Paik Hospital and were transferred to PC in order to reconstruct MR images and temperature map using proton resonance frequency(PRF) method and laboratory-developed phase unwrapping algorithm. Authors found that it has no severe distortion due to the antenna inserted into the phantom. Finally, we can conclude that the suggested coaxial-slot antenna has an excellent local heating performance for both of tissue-mimic phantom and swine muscle, and it is compatible to 1.5T MRI scanner.

키워드

참고문헌

  1. K.S. Shin, H.S. Shin, and N. Kim, 'SAR Analysis on the Coaxial-Slot Antenna for Hyperthermia', Journal of KIEES, vol. 13, no. 7, pp. 732-739, 2002
  2. S.S. Han, 'Extracorporeal High intensity focused ultrasound therapy', J. of Korean Bone & Joint Tumor Soc., vol. 11, no. 1, pp. 17-24, 2005
  3. O. Rouviere, R. Souchon, R. Salomir, A. Gelet, J.Y. Chapelon, and D. Lyonnet, 'Transrectal high-intensity focused ultrasound ablation of prostate cancer: Effective treatment requiring accurate imaging', European J. of Radiology, vol. 63, pp. 317-327, 2007 https://doi.org/10.1016/j.ejrad.2007.06.026
  4. K.H. Haraldsdottir, K. Ivarsson, S. Gotberg, C. Ingvar, U. Stenram, and K.G. Tranberg, 'Interstitial laser thermotherapy(ILT) of breast cancer', EJSO, vol. 34, pp. 739-745, 2008 https://doi.org/10.1016/j.ejso.2008.01.008
  5. S.A. Curley, 'Radiofrequency ablation of malignant liver tumors', The Oncologist, vol. 6, pp. 14-23, 2001 https://doi.org/10.1634/theoncologist.6-1-14
  6. K. Sato, S. Morikawa, T. Inubushi, Y. Kurumi, S. Naka, H.A. Haque, K. Demura, and T. Tani, 'Alternate biplanar MR navigation for microwave ablation of liver tumors', Magnetic Resonance in Medical Sciences, vol. 4, no. 2, pp. 89-94, 2005 https://doi.org/10.2463/mrms.4.89
  7. M.S. Breen, K. Butts, L. Chen, G.M. Saidel, and D.L. Wilson, 'MRI-guided laser thermal ablation: Model to predict cell death from MR thermometry images for real-time therapy monitoring', in Proc. 26th IEEE EMBS, CA, USA, Sep. 2004, pp. 1028-1031
  8. C.M.C. Tempany, E.A. Stewart, N. McDannold, B.J. Quade, F.A. Jolesz, and K. Hynynen, 'MR imaging-guided focused ultrasound surgery of uterine leiomyomas: A feasibility study', Radiology, vol. 226, no. 3, pp. 897-905, 2003 https://doi.org/10.1148/radiol.2271020395
  9. E.A. stewart et al., 'Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids', ASRM, vol. 85, no. 1, pp. 22-29, 2006 https://doi.org/10.1016/j.fertnstert.2005.04.072
  10. H. Furusawa, K. Namba, S. Thomsen, F. Akiyama, A. Bendet, C. Tanaka, Y. Yasuda, and H. Nakahara, 'Magnetin resonanceguided focused ultrasound surgery of breast cancer: Reliability and Effectiveness', The American College of Surgeons, vol. 203, no. 1, pp. 54-63, 2006 https://doi.org/10.1016/j.jamcollsurg.2006.04.002
  11. T. Uchida, H. Ohkusa, H. Yamashita, S. Shoji, Y. Nagata, T. Hyodo, and T. Satoh, 'Five years experience of transrectal high-intensity focused ultrasound using the sonablate device in the treatment of localized prostate cancer', J. of Urology, vol. 13, pp. 228-233, 2006 https://doi.org/10.1111/j.1442-2042.2006.01272.x
  12. D.B. Zippel and M.Z. Papa, 'The use of MR imaging guided focused ultrasound in breast cancer patients; a preliminary phase one study and review', Breast Cancer, vol. 12, no. 1, pp.32-38, 2005 https://doi.org/10.2325/jbcs.12.32
  13. M.L. Coiffe, B. Quesson, O. Seror, E. Dumont, B.L. Bail, T.W. Moonen and H. Trillaud, 'Real-time monitoring of radiofrequency ablation of rabbit liver by respiratoty-gated quantitative temperature MRI', J. of MRM, vol. 24, pp. 152-159, 2006 https://doi.org/10.1002/jmri.20605
  14. D. Germain, P. Chevallier, A. Laurent, M. Savart, M. Wassef, and H.S. Jalmes, 'MR monitoring of laser-induced lesion of the liver in vivo in a low-field open magnet: Temperature mapping and lesion size prediction', J. of MRM, vol. 13, pp. 42-49, 2001 https://doi.org/10.1002/1522-2586(200101)13:1<42::AID-JMRI1007>3.0.CO;2-8
  15. C. Mougenot, R. Salomir, J. Palussiere, N. Grenier, and T.W. Moonen, 'Automatic spatial and temporal temperature control for MR-guided focused ultrasound using fast 3D MR thermometry and multispiral tragectory of the focal point', Magnetic Resonance in Medicine, vol. 52, pp. 1005-1015, 2004 https://doi.org/10.1002/mrm.20280
  16. B.D. Senneville, C. Mougenot, B. Quesson, I. Dragonu, N. Grenier, and T.W. Moonen, 'MR thermometry for monitoring tumor ablation', Eur Radiol, vol. 17, pp. 2401-2410, 2007 https://doi.org/10.1007/s00330-007-0646-6
  17. F. Sterzer, 'Microwave Medical Devices', IEEE microwave magazine, pp. 65-70, 2002 https://doi.org/10.1109/6668.990689
  18. C. Gabriel, Compilation of the dielectric properties of body tissues at RF and microwave frequencies. Brooks Air Force Technical Report AL/OE-TR-1996-0037 (see http://www.fcc.gov/fcc-bin/dielec.sh)
  19. C.K. Tan, T.H. Kim, S.I. Chun, Y.H. Han, K.I. Choi, K.S. Lee, J.R. Jun, C.K. Eun, C.W. Mun, 'Preliminary Study on the MR temperature mapping using Center Array-Sequencing Phase Unwrapping Algorithm', JKSMRM, vol. 12, pp131-141, 2008