The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Horse Bone Powder Extract on Longitudinal Bone Growth in Adolescent Male Rats

마골(馬骨) 추출물의 성장기 흰쥐 장골 길이 성장에 대한 효과

  • Lee, Se-Na (Department of Herbology, College of Oriental Medicine, Semyung University) ;
  • Choi, Han (IGSbio Co. Ltd) ;
  • Son, Jae-Bong (Department of Herbology, College of Oriental Medicine, Semyung University) ;
  • Jeong, Jae-Seung (Department of Herbology, College of Oriental Medicine, Semyung University) ;
  • Kim, Yun-Jung (IGSbio Co. Ltd) ;
  • Kang, Dae-Pyung (Jeju Industrial Horse a Limited Company) ;
  • Park, Soo-Yeong (Jeju Biodiversity Research Institute, Jeju Hi-Tech Industry Development Institute) ;
  • Kang, Se-Chan (Department of Natural Medicine Resources, Semyung Unversity) ;
  • Leem, Kang-Hyun (Department of Herbology, College of Oriental Medicine, Semyung University)
  • 이세나 (세명대학교 한의과대학 본초학교실) ;
  • 최한 ((주) 아이지에스) ;
  • 손재봉 (세명대학교 한의과대학 본초학교실) ;
  • 정재승 (세명대학교 한의과대학 본초학교실) ;
  • 김윤정 ((주) 아이지에스) ;
  • 강대평 (제주마산업(주)) ;
  • 박수영 (제주하이테크산업진흥원 제주생물종다양성연구소) ;
  • 강세찬 (세명대학교 자연약재과학과) ;
  • 임강현 (세명대학교 한의과대학 본초학교실)
  • Published : 2009.09.30
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Abstract

Objectives : This study was designed to investigate the effects of horse bone powder extract on the growth of longitudinal bone in adolescent male rats. Methods： Longitudinal bone growth was measured by fluorescent microscopy. To examine the effects on the growth plate metabolism, the total height of growth plate, the induction of local insulin-like growth factor-1 (IGF-1), and bone morphogenetic protein-2 (BMP-2) were measured. Results： Horse bone powder extract enhanced longitudinal bone growth and total height of the growth plate. Also, it promoted the induction of local IGF-1 and BMP-2 of the growth plate. Conclusions： This study shows that the horse bone powder extract effects longitudinal bone growth in adolescent rats and might be used for both stunted adolescents and inherent growth failure patients.

Keywords

References

  1. 서정희, 백재화, 김효철. 청소년소비자의 외모와 능력에 대한 만족과 평가 및 자아 존중감. 생활과학논문집. 2004 ; 5(2) : 53-68.
  2. 심미경, 이종한, 박은아. 청소년의 신체지각과 통제신념에 따른 신체관리행동. 한국심리학회 연차학술발표대회 논문집. 2008 : 660-1.
  3. 이중재. 의종필독(상). 서울 : 木과 土. 2000 : 22-4.
  4. 김덕곤, 김윤희, 김장현, 박은정, 백정한, 이승연, 이진용, 장규태. 동의소아과학. 서울 : 정담. 2002 : 353, 406-7.
  5. 임강현, 김호현. 成長관련 한약 혼합제제의 흰쥐 장골 길이成長에 대한 효과. 대한본초학회지. 2003 ; 18(3) : 181-6.
  6. 양종훈. 제주 조랑말(1). 한국사진학회. 2000 ; 7(1) : 231-7.
  7. 김지민. 난소적출 후 칼슘결핍식이로 유발시킨 흰쥐의 골다공증에 대한 말뼈분말의 개선효과. 제주대학교 대학원 수의학과 석사학위논문. 2007.
  8. 박선순. 말뼈 추출물이 뼈질환 인자에 미치는 영향. 제주대학교 대학원 의학과 석사학위논문. 2009.
  9. 國家中醫藥管理局 中華本草篇委會. 中華本草. 上海科學技術出版社. 1998 ; 9 : 609.
  10. 許浚. 東醫寶鑑. 여강출판사. 2005 : 2825.
  11. Hansson LI, Menander-Sellman K, Stenstrom A, Thorngren KG. Rate of normal longitudinal bone growth in the rat. Calcif Tissue Res. 1972 ; 10 : 238-51. https://doi.org/10.1007/BF02012553
  12. De Luca F, Barnes KM, Uyeda JA, De-Levi S, Abad V, Palese T, Mericq V, Baron J. Regulation of growth plate chondrogenesis by bone morphogenetic protein-2. Endocrinology. 2001 ; 142(1) : 430-6. https://doi.org/10.1210/en.142.1.430
  13. 양동식, 차민호, 강봉주, 오세욱, 김영언, 윤유식. 가시오가피가 함유된 성장촉진용 조성물의 골성장효과 연구. 한국식품과학회지. 2003 ; 35(4) : 702-7.
  14. Forriol F, Shapiro F. Bone development: interaction of molecular components and biophysical forces. Clin Orthop Relat Res. 2005 : Mar(432) : 14-33.
  15. Netter FH. Musculoskeletal system : anatomy, physiology, and metabolic disorders. New Jersey : Ciba-Geigy Corporation. 1987 : 130.
  16. Brighton CT, Yoichi S and Robert MH. Cytoplasmic structures of epiphyseal plate chondrocytes; quantitative evaluation using electron micrographs of rat costochondral junctions with specific reference to the fate of hypertrophic cells. Journal of Bone and Joint Surgery. 1973 ; 55-A : 771-84.
  17. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol. 2008 ; 40(1) : 46-62. https://doi.org/10.1016/j.biocel.2007.06.009
  18. Gerard JT, Sandra RG. Principles of anatomy & physiolosy (10th edition). USA : Wiley. 2003 : 174.
  19. Scriver CR, Beaudet AL, Sly WS, Valle D. The Metabolic and Molecular Bases of Inherited Disease. Vol. II (7th edition). New York : McGraw-Hill. 1995 : 3023-44.
  20. Wang EA, Rosen V, D'Alessandro JS, Bauduy M, Cordes P, Harada T, Israel DI, Hewick RM, Kerns KM, LaPan P, Luxenberg DP, McQuaid D, Moutsatsos IK, Nove J, Wozney JM. Recombinant human bone morphogenetic protein induces bone formation. Proc Nat Acad Sci. 1990 ; 87 : 2220-4. https://doi.org/10.1073/pnas.87.6.2220
  21. Hallahan AR, Pritchard JI, Chandraratna RAS, Ellenbogen RG, Geyer JR, Overland RP, Strand AD, Tapscott SJ, Olson JM. BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nature Med. 2003 ; 9 : 1033-8. https://doi.org/10.1038/nm904
  22. Cancedda R, Descalzi Cancedda F, Castagnola P. Chondrocyte differentiation. Int Rev Cytol. 1995 ; 159 : 265-358. https://doi.org/10.1016/S0074-7696(08)62109-9
  23. 고문석, 이영재. 말뼈 성분 급여가 쥐의 생리기능에 미치는 영향. 난지농업연구소. 2006.
  24. 이종언. 말고기와 말뼈의 영양 특성. 난지농업연구지. 2006 ; 15 : 20-2.