Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
권호 표지
DOI QR코드

DOI QR Code

A Case of Anaphylaxis after the Treatment with Etoposide in a Patient with Small Cell Lung Cancer

소세포폐암에서 Etoposide 투여 후 발생한 아나필락시스 1예

  • Kim, Young-Il (Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Chonnam National University Medical School) ;
  • Kim, Kyu-Sik (Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Chonnam National University Medical School) ;
  • Han, Eui-Ryoung (Department of Internal Medicine, Division of Allergy, Asthma and Clinical Immunology, Chonnam National University Medical School) ;
  • Kwan, Yong-Soo (Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Chonnam National University Medical School) ;
  • Oh, In-Jae (Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Chonnam National University Medical School) ;
  • Lim, Sung-Chul (Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Chonnam National University Medical School) ;
  • Kim, Young-Chul (Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Chonnam National University Medical School)
  • 김영일 (전남대학교 의과대학 호흡기내과학교실) ;
  • 김규식 (전남대학교 의과대학 호흡기내과학교실) ;
  • 한의령 (전남대학교 의과대학 알레르기내과학교실) ;
  • 권용수 (전남대학교 의과대학 호흡기내과학교실) ;
  • 오인재 (전남대학교 의과대학 호흡기내과학교실) ;
  • 임성철 (전남대학교 의과대학 호흡기내과학교실) ;
  • 김영철 (전남대학교 의과대학 호흡기내과학교실)
  • Received : 2009.06.23
  • Accepted : 2009.08.11
  • Published : 2009.08.30
Download PDF
⟨ Previous Next ⟩

Abstract

Etoposide is a semi-synthetic derivative of podophyllotoxin that is effective against many cancers including small cell lung cancer. We report a case of etoposide-induced anaphylaxis in a 51-year-old woman who tolerated etoposide during her first cycle chemotherapy regimen. During the second cycle, she complained of generalized urticaria and dyspnea 5 minutes after being infused with etoposide. She recovered completely with antihistamine, corticosteroid and fluid replacement. The intradermal skin test with etoposide showed a clear positive immediate reaction. This case suggests that etoposide can induce IgE-mediated anaphylaxis.

Keywords

References

  1. Weiss RB. Chaptor 35. Hypersensitivity reactions. In: Perry MC, editor. The chemotherapy source book. 3rd ed. Baltimore: Williams & Wilkins, Inc.; 2001. p. 436-52
  2. Sandler AB. Chemotherapy for small cell lung cancer. Semin Oncol 2003;30:9-25
  3. Collier K, Schink C, Young AM, How K, Seckl M, Savage P. Successful treatment with etoposide phosphate in patients with previous etoposide hypersensitivity. J Oncol Pharm Pract 2008;14:51-5 https://doi.org/10.1177/1078155207085355
  4. Siderov J, Prasad P, De Boer R, Desai J. Safe administration of etoposide phosphate after hypersensitivity reaction to intravenous etoposide. Br J Cancer 2002;86:12-3 https://doi.org/10.1038/sj.bjc.6600003
  5. Bernstein BJ, Troner MB. Successful rechallenge with etoposide phosphate after an acute hypersensitivity reaction to etoposide. Pharmacotherapy 1999;19:989-91 https://doi.org/10.1592/phco.19.11.989.31566
  6. Hoetelmans RM, Schornagel JH, Ten Bokkel Huinink WW, Beijnen JH. Hypersensitivity reactions to etoposide. Ann Pharmacother 1996;30:367-71 https://doi.org/10.1177/106002809603000409
  7. Kasperek C, Black CD. Two cases of suspected immunologic-based hypersensitivity reactions to etoposide therapy. Ann Pharmacother 1992;26:1227-30 https://doi.org/10.1177/106002809202601005
  8. Taguchi A, Takeshita S, Machida R, Hori Y, Aida K, Furuya U, et al. Anaphylaxia induced by etoposide: a case report. Gan To Kagaku Ryoho 2003;30:1187-9
  9. Hudson MM, Weinstein HJ, Donaldson SS, Greenwald C, Kun L, Tarbell NJ, et al. Acute hypersensitivity reactions to etoposide in a VEPA regimen for Hodgkin's disease. J Clin Oncol 1993;11:1080-4 https://doi.org/10.1200/JCO.1993.11.6.1080
  10. Eschalier A, Lavarenne J, Burtin C, Renoux M, Chapuy E, Rodriguez M. Study of histamine release induced by acute administration of antitumor agents in dogs. Cancer Chemother Pharmacol 1988;21:246-50
  11. O'Dwyer PJ, King SA, Fortner CL, Leyland-Jones B. Hypersensitivity reactions to teniposide (VM-26): an analysis. J Clin Oncol 1986;4:1262-9 https://doi.org/10.1200/JCO.1986.4.8.1262

Cited by

  1. Overview of anaphylaxis in Korea: diagnosis and management vol.1, pp.3, 2013, https://doi.org/10.4168/aard.2013.1.3.181