Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Hypersensitivity Pneumonitis Following Placenta Extract Injection

태반 추출물 주사 후 발생한 과민성 폐장염 1예

  • Lee, Sang Seok (Division of Pulmonology and Allergy, Department of Internal Medicine, Dankook University College of Medicine) ;
  • Choo, Young Kwang (Division of Pulmonology and Allergy, Department of Internal Medicine, Dankook University College of Medicine) ;
  • Bang, Chang Seok (Division of Pulmonology and Allergy, Department of Internal Medicine, Dankook University College of Medicine) ;
  • Kim, Youn Seup (Division of Pulmonology and Allergy, Department of Internal Medicine, Dankook University College of Medicine) ;
  • Park, Jae Seuk (Division of Pulmonology and Allergy, Department of Internal Medicine, Dankook University College of Medicine) ;
  • Jee, Young Koo (Division of Pulmonology and Allergy, Department of Internal Medicine, Dankook University College of Medicine) ;
  • Kim, Doh Hyung (Division of Pulmonology and Allergy, Department of Internal Medicine, Dankook University College of Medicine) ;
  • Myong, Na Hye (Department of Pathology, Dankook University College of Medicine)
  • 이상석 (단국대학교 의과대학 내과학교실) ;
  • 추영광 (단국대학교 의과대학 내과학교실) ;
  • 방창석 (단국대학교 의과대학 내과학교실) ;
  • 김윤섭 (단국대학교 의과대학 내과학교실) ;
  • 박재석 (단국대학교 의과대학 내과학교실) ;
  • 지영구 (단국대학교 의과대학 내과학교실) ;
  • 김도형 (단국대학교 의과대학 내과학교실) ;
  • 명나혜 (단국대학교 의과대학 병리학교실)
  • Received : 2009.05.18
  • Accepted : 2009.06.19
  • Published : 2009.06.30
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Abstract

Human placenta contains various kinds of nutritional elements essential for embryonic development. Currently, human placenta extracts are widely overused in Korea to improve certain health conditions (postmenopausal syndrome, liver function, and cosmetic purposes) without scientific evidence that they actually work. The use of placenta extracts should be restricted, due to a lack of systematic research on the therapeutic effectiveness and adverse results from these treatments. While the common adverse effects that have been reported are fever, rash, itching, nausea, vomiting, breast pain, and rare cases of anaphylactic shock, there have been no reports of pulmonary complications such as hypersensitivity pneumonitis. Recently, we experienced a patient with hypersensitivity pneumonitis following a placenta extract injection. To our knowledge, this is the first case of hypersensitivity pneumonitis associated with placenta extract use.

과민성 폐장염은 감수성 있는 사람이 특정 유발물질에 노출됨으로써 폐실질과 말초 기관지에 육아종성 염증을 일으키는 면역질환이다. 과민성 폐장염은 동물성 및 식물성 항원, 저분자 화학 물질, 세균 및 곰팡이 등의 미생물 흡인에 의해 유발 될 수 있으나 본 증례처럼 주사제에 의한 사례는 매우 드물다. 저자들은 특별한 노출력 없는 건강한 여성에서 태반 추출물 주사 후 발생한 과민성 폐장염의 첫 사례를 경험하여 보고하는 바이다.

Keywords

References

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