Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
권호 표지
DOI QR코드

DOI QR Code

A Case of Bronchiectasis with Elevated Serum CA 125 Level

혈중 CA 125 수치가 지속적으로 상승되었던 기관지확장증 1예

  • Shin, Bong Chul (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Koo, Tae Hyoung (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Kim, Sang Ock (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Ter, Hsing Chien (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Um, Soo Jung (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Lee, Soo-Keol (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Son, Choon Hee (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Kim, Ki Nam (Department of Radiology, Dong-A University College of Medicine) ;
  • Lee, Ki-Nam (Department of Radiology, Dong-A University College of Medicine) ;
  • Roh, Mee Sook (Department of Pathology, Dong-A University College of Medicine) ;
  • Choi, Pil Jo (Department of Thoracic and Cardiovascular Surgery, Dong-A University College of Medicine)
  • 신봉철 (동아대학교 의과대학 내과학교실) ;
  • 구태형 (동아대학교 의과대학 내과학교실) ;
  • 김상옥 (동아대학교 의과대학 내과학교실) ;
  • 형건덕 (동아대학교 의과대학 내과학교실) ;
  • 엄수정 (동아대학교 의과대학 내과학교실) ;
  • 이수걸 (동아대학교 의과대학 내과학교실) ;
  • 손춘희 (동아대학교 의과대학 내과학교실) ;
  • 김기남 (동아대학교 의과대학 영상의학교실) ;
  • 이기남 (동아대학교 의과대학 영상의학교실) ;
  • 노미숙 (동아대학교 의과대학 해부병리학교실) ;
  • 최필조 (동아대학교 의과대학 흉부외과학교실)
  • Received : 2009.04.23
  • Accepted : 2009.06.17
  • Published : 2009.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Serum CA 125 is the most useful marker for monitoring patients with epithelial ovarian cancer. However, it can be elevated above normal level in a variety of conditions other than ovarian cancer such as endometriosis, pelvic inflammation disease, and other malignant or nonmalignant disorders, including pulmonary diseases. Recently, we experienced a case of bronchiectasis in which the serum CA 125 level was elevated, changing with the patient's condition. There was no evidence of underlying malignant disease on positron emission tomography or on gynecologic examination, including transvaginal ultrasonography. During follow-up for 14 months, we could not find any clue of malignant disease that could have been the cause of the elevated levels of serum CA 125. Elevated serum CA 125 level should be interpreted carefully according to the patient's clinical condition. In addition, our case suggests that CA 125 may be used as a surrogate marker for acute inflammatory status for chronic pulmonary diseases.

CA 125의 상승은 난소의 악성종양에 나타날 수 있지만 비특이적이다. CA 125의 상승은 다양한 양성 질환 혹은 악성 종양에서 나타날 수 있다. 저자들은 최근 지속적으로 혈중 CA 125 수치가 증가되어 있지만 경질 초음파, 흉부 CT, PET-CT 등에서 악성 종양이 발견되지 않은 기관지확장증 1예를 경험하였다. 14개월의 추적 관찰 기간 중에도 난소암과 같은 악성 종양은 발견되지 않고 기관지확장증에 병발된 폐렴 이외에는 특이 소견이 없어, 혈중 CA 125의 상승은 기관지확장증에 의한 급성 폐 손상에 의한 것으로 추정된다. 혈중 CA 125 수치의 상승은 환자의 임상 양상과 연관하여 조심스럽게 판단하여야 될 것으로 생각된다.

Keywords

References

  1. Bast RC Jr, Xu FJ, Yu YH, Barnhill S, Zhang Z, Mills GB. CA 125: the past and the future. Int J Biol Markers 1998;13:179-87
  2. Topalak O, Saygili U, Soyturk M, Karaca N, Batur Y, Uslu T, et al. Serum, pleural effusion, and ascites CA-125 levels in ovarian cancer and nonovarian benign and malignant diseases: a comparative study. Gynecol Oncol 2002;85:108-13 https://doi.org/10.1006/gyno.2001.6575
  3. Buamah P. Benign conditions associated with raised serum CA-125 concentration. J Surg Oncol 2000;75: 264-5 https://doi.org/10.1002/1096-9098(200012)75:4<264::AID-JSO7>3.0.CO;2-Q
  4. Miralles C, Orea M, España P, Provencio M, Sánchez A, Cantos B, et al. Cancer antigen 125 associated with multiple benign and malignant pathologies. Ann Surg Oncol 2003;10:150-4 https://doi.org/10.1245/ASO.2003.05.015
  5. Marechal F, Berthiot G, Deltour G. Serum levels of CA-50, CA-19.9, CA-125, CA-15.3, enolase and carcinoembryonic antigen in non neoplastic diseases of the lung. Anticancer Res 1988;8:677-80
  6. Sevinc A, Camci C, Turk HM, Buyukberber S. How to interpret serum CA 125 levels in patients with serosal involvement? A clinical dilemma. Oncology 2003;65: 1-6
  7. Meyer T, Rustin GJ. Role of tumour markers in monitoring epithelial ovarian cancer. Br J Cancer 2000;82: 1535-8 https://doi.org/10.1054/bjoc.2000.1174
  8. Bischof P. What do we know about the origin of CA 125? Eur J Obstet Gynecol Reprod Biol 1993;49:93-8 https://doi.org/10.1016/0028-2243(93)90131-U
  9. Ozsahin SL, Turgut B, Nur N, Dogan OT, Erselcan T, Berk S. Validity of the CA125 level in the differential diagnosis of pulmonary tuberculosis. Jpn J Infect Dis 2008;61:68-9
  10. Kodama T, Satoh H, Ishikawa H, Ohtsuka M. Serum levels of CA19-9 in patients with nonmalignant respiratory diseases. J Clin Lab Anal 2007;21:103-6 https://doi.org/10.1002/jcla.20136
  11. Yilmaz A, Ece F, Bayramgürler B, Akkaya E, Baran R. The value of CA 125 in the evaluation of tuberculosis activity. Respir Med 2001;95:666-9 https://doi.org/10.1053/rmed.2001.1121