Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Pulmonary Thromboembolism in Crohn's Disease

크론병 환자에서 발생한 폐동맥 색전증 1예

  • Chung, Eui-Sung (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kim, Jeong-Ho (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Jung, Jin-Hwan (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Shin, Ju-Young (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Yeom, Ju Ok (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kang, Ji Young (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Yoon, Hyoung-Kyu (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Song, Jeong Sup (Department of Internal Medicine, The Catholic University of Korea College of Medicine)
  • 정의성 (가톨릭대학교 의과대학 내과학교실) ;
  • 김정호 (가톨릭대학교 의과대학 내과학교실) ;
  • 정진환 (가톨릭대학교 의과대학 내과학교실) ;
  • 신주영 (가톨릭대학교 의과대학 내과학교실) ;
  • 염주옥 (가톨릭대학교 의과대학 내과학교실) ;
  • 강지영 (가톨릭대학교 의과대학 내과학교실) ;
  • 윤형규 (가톨릭대학교 의과대학 내과학교실) ;
  • 송정섭 (가톨릭대학교 의과대학 내과학교실)
  • Received : 2009.04.15
  • Accepted : 2009.05.12
  • Published : 2009.05.30
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Abstract

Crohn's disease, a major form of inflammatory bowel disease (IBD), is a chronic inflammatory condition that is characterized by microvascular and macrovascular involvement. Some extraintestinal complications can occur due to chronic systemic inflammation in IBD. Among them, a pulmonary thromboembolism is a rare manifestation of IBD but is associated with a high morbidity and mortality. To our best of knowledge, there is only one case report of a pulmonary thromboembolism as a complication of Crohn's disease in Korea. We present another rare case of pulmonary thromboembolism as complication in a 25-year-old man with underlying Crohn's disease.

폐동맥 색전증은 적절한 치료를 하지 않으면 사망률이 30%에 이르는 치명적인 질환이다. 장기간의 부동 상태, 수술, 악성 종양 등이 흔한 위험 인자이나, 크론병과 같은 염증성 장질환 또한 드물지만 폐동맥 혈전증을 일으킨다고 알려져 있다. 저자들은 3년 전 혈변과 설사로 크론병을 진단받고 재발 및 관해를 반복하던 25세 남자에서 폐동맥 색전증이 병발한 드문 예를 경험하였기에 증례 보고를 하는 바이다.

Keywords

References

  1. Wells PS, Owen C, Doucette S, Fergusson D, Tran H. Does this patient have deep vein thrombosis? JAMA 2006;295:199-207 https://doi.org/10.1001/jama.295.2.199
  2. Calder KK, Herbert M, Henderson SO. The mortality of untreated pulmonary embolism in emergency department patients. Ann Emerg Med 2005;45:302-10 https://doi.org/10.1016/j.annemergmed.2004.10.001
  3. Scientific Committee for National Survey of Acute Pulmonary Thromboembolism, Korean Academy of Tuberculosis and Respiratory Diseases. The national survey of acute pulmonary thromboembolism in Korea. Tuberc Respir Dis 2003;54:5-14
  4. Papa A, Scaldaferri F, Danese S, Guglielmo S, Roberto I, Bonizzi M, et al. Vascular involvement in inflammatory bowel disease: pathogenesis and clinical aspects. Dig Dis 2008;26:149-55 https://doi.org/10.1159/000116773
  5. Miehsler W, Reinisch W, Valic E, Osterode W, Tillinger W, Feichtenschlager T, et al. Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism? Gut 2004;53:542-8 https://doi.org/10.1136/gut.2003.025411
  6. Chung C, Kang DH, Kim EA, Hong SH, Kong HS, Park HC, et al. A case of pulmonary embolism in recurrent ileal Crohn’s disease after total colectomy. Korean J Gastrointest Endosc 2001;22:111-5
  7. Bargen JA, Barker NW. Extensive arterial and venous thrombosis complicating chronic ulcerative colitis. Arch Intern Med 1936;58:17-31 https://doi.org/10.1001/archinte.1936.00170110025002
  8. Solem CA, Loftus EV, Tremaine WJ, Sandborn WJ. Venous thromboembolism in inflammatory bowel disease. Am J Gastroenterol 2004;99:97-101 https://doi.org/10.1046/j.1572-0241.2003.04026.x
  9. Liebman HA, Kashani N, Sutherland D, McGehee W, Kam AL. The factor V Leiden mutation increases the risk of venous thrombosis in patients with inflammatory bowel disease. Gastroenterology 1998;115:830-4 https://doi.org/10.1016/S0016-5085(98)70253-7
  10. Jackson LM, O'Gorman PJ, O'Connell J, Cronin CC, Cotter KP, Shanahan F. Thrombosis in inflammatory bowel disease: clinical setting, procoagulant profile and factor V Leiden. QJM 1997;90:183-8 https://doi.org/10.1093/qjmed/90.3.183
  11. Collins CE, Rampton DS. Review article: platelets in inflammatory bowel disease--pathogenetic role and therapeutic implications. Aliment Pharmacol Ther 1997;11:237-47 https://doi.org/10.1046/j.1365-2036.1997.153328000.x
  12. Sonoda K, Ikeda S, Mizuta Y, Miyahara Y, Kohno S. Evaluation of venous thromboembolism and coagulation- fibrinolysis markers in Japanese patients with inflammatory bowel disease. J Gastroenterol 2004;39:948-54 https://doi.org/10.1007/s00535-004-1426-6

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