Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Alpha-glucosidase Inhibitors from the Branches Extract of Cotinus coggygria

안개나무 가지 추출물로부터 분리한 $\alpha$-glucosidase 저해활성물질

  • Published : 2009.09.30
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Abstract

The ethanol (EtOH) extract of the branches of Cotinus coggygria (Anacardiaceae) exhibited a significant inhibition on the yeast $\alpha$-glucosidase, one of the key enzymes related with diabetes mellitus, in a dose dependent manner, in vitro. The intensive phytochemical survey of the EtOH extract of the species by way of bioactivity-guided fractionation resulted in the isolation of 1,2,3,4,6-penta-O-galloyl-$\beta$-D-glucose (1) as an active principle responsible for the inhibition on $\alpha$-glucosidase, together with two related components 2 and 3. Compound 1 demonstrated a strong inhibition on the yeast $\alpha$-glucosidase, in vitro and $IC_{50}$ value was calculated as 0.96 mg/ml, when that of a reference drug, acarbose was estimated as 5.3 mg/ml. On the other hand, other related constituents of the species, 1,2,3,6-tetra-O-galloyl-$\beta$-D-glucose (2) and gallic acid (3) were exhibited relatively poor inhibition upon the yeast $\alpha$-glucosidase, respectively.

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References

  1. Woo, J. T., Kim, Y. S., Choi, Y. K., Kim, J. W., Yang, I. M., Kim, S. W., Kim, D. Y., Kim, K. W., Lee, M. K., Lee, M. S. and Jung, J. H. (1998) Lowering effect of voglibose, monotherapy on uncontrolled postprandial glucose in patients with non-insulin dependent diabetes mellitus (NIDDM) being treated with strict diet control. J. Korean Diabet. Assoc. 22:419-428
  2. Choi, H. J., Kang, J. S., Choi, Y. W., Jeong, Y. K. and Joo, W. H. (2008) Inhibitory activity on the diabetes related enzymes of Tetragonia tetragonioides. Korean J. Biotechnol. Bioeng. 23: 419-424
  3. DeFronzo, R. A. (1992) Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview. Diabetologia 35: 389-397 https://doi.org/10.1007/BF00401208
  4. Schwartz, S., Raskin, P., Fonseca, V. and Graveline, J. F. (1998) Effect of troglitazone in insulin-treated patients with type II diabetes mellitus. N. Engl. J. Med. 338: 861-866 https://doi.org/10.1056/NEJM199803263381302
  5. Hong, S. H., Kim, M. J., Noh, S. G., Suh, D. W., Youn, S. J., Lee, K. W., Lee, H. C., Chung, Y. S., Chung, H. R., Kwon, H. S., Cha, B. Y., Son, H. Y. and Yoon, K. H. (2008) A study on resistance in type 2 diabetic patient against commencement of insulin treatment. Korean Diabetes J. 32: 269-279 https://doi.org/10.4093/kdj.2008.32.3.269
  6. Wansi, J. D., Lallemand, M. C., Chiozem, D. D., Toze, F. A. A., Mbaze, L. M., Naharkhan, S., Iqbal, M. C., Tillequin, F., Wandji, J. and Fomum, Z. T. (2007) $\alpha$-Glucosidase inhibitory constituents from stem bark of Terminalia superba (Combretaceae). Phytochemistry 68: 2096-2100 https://doi.org/10.1016/j.phytochem.2007.02.020
  7. Del Prato, S., Bianchi, C. and Marchetti, P. (2007) Beta-cell function and anti-diabetic pharmacotherapy. Diabetes-Metab. Res. Rev. 23: 518-527 https://doi.org/10.1002/dmrr.770
  8. Van de Laar, F. A., Lucassen, P. L., Akkermans, R. P., Van de Lisdonk, E. H. and De Grauw WJ. (2009) Alpha-glucosidase inhibitors for people with impaired glucose tolerance or impaired fasting blood glucose. Cochrane Database Syst. Rev. 18: CD005061 https://doi.org/10.1002/14651858.CD005061.pub2
  9. Tsujimoto, T., Shioyama, E., Moriya, K., Kawaratani, H., Shirai, Y., Toyohara, M., Mitoro, A., Yamao, J., Fujii, H. and Fukui H. (2008) Pneumatosis cystoides intestinalis following alpha-glucosidase inhibitor treatment: a case report and review of the literature. World J. Gastroenterol. 14: 6087-6092 https://doi.org/10.3748/wjg.14.6087
  10. Westenburg, H. E., Lee, K. J., Lee, S. K., Fong, H. H. S., van Breemen, R. B., Pezzuto, J. M. and Kinghorn, A. D. (2000) Activity-guided isolation of antioxidative constituents of Cotinus coggygria. J. Nat. Prod. 63: 1696-1698 https://doi.org/10.1021/np000292h
  11. Tsankova, E. T., Dyulgerov, A. S. and Milenkov, B. K. (1993) Chemical composition of the Bulgarian sumac oil. J. Essent. Oil Res. 5: 205-207
  12. Demirci, B., Demirci, F. and Baser, K. H. C. (2003) Composition of the essential oil of Cotinus coggygria Scop. from Turkey. Flavour Fragr. J. 18: 43-44 https://doi.org/10.1002/ffj.1149
  13. Kim, J. S., Kwon, C. S. and Son, K. H. (2000) Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Biosci. Biotechnol. Biochem. 64: 2458-2461 https://doi.org/10.1271/bbb.64.2458
  14. Murray, N. J., Williamson, M. P., Lilley, T. H. and Haslam E. (1994) Study of the interaction between salivary proline-rich proteins and a polyphenol by 1 H-NMR spectroscopy. Eur. J. Biochem. 219: 923-935 https://doi.org/10.1111/j.1432-1033.1994.tb18574.x
  15. Zhang, Y., DeWitt, D. L., Murugesan, S. and Nair, M. G. (2004) Novel lipid-peroxidation and cyclooxygenase-inhibitory tannins from Picrorhiza kurroa Seeds. Chem. Biodivers. 1: 426-441 https://doi.org/10.1002/cbdv.200490036