The Korean Journal of Nuclear Medicine Technology (핵의학기술)

The Korean Society of Nuclear Medicine Technology (대한핵의학기술학회)
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Estimation of Glomerular Filtration Rate using Chromium-51 EDTA

Cr-51 EDTA GFR 검사 결과의 분석 및 의의

  • Lim, Soo-Yeon (Department of Nuclear Medicine, Asan Medical Center) ;
  • Moon, Hyoung-Ho (Department of Nuclear Medicine, Asan Medical Center) ;
  • Yoo, Seon-Hee (Department of Nuclear Medicine, Asan Medical Center) ;
  • Cho, Shee-Man (Department of Nuclear Medicine, Asan Medical Center)
  • Received : 2009.01.07
  • Accepted : 2009.02.05
  • Published : 2009.05.11
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Abstract

Purpose: Correct estimation of Glomerular filtration rate (GFR) is very important for an accurate clinical assessment of the kidney function. This study compares four GFR markers, a serum creatinine-based estimation using MDRD formula, Cystatin-C, Cr-51 EDTA 2 samples and 6 samples. Materials and Methods: Serum creatinine concentrations, Cystatin-C serum concentrations and Cr-51 EDTA clearance are measured in 43 patients who received or donated kidney. Results: The correlation coefficient between serum based estimated GFR (MDRD) and Cr-51 EDTA 6 samples was 0.817 (p<0.01). The correlation coefficient between Cystatin-C based GFR and EDTA 6 samples was 0.7322 (p<0.01). Regression analysis showed a statistically significant correlation between Cr-51 EDTA 2 samples and 6 samples (r=0.971, p<0.01). Mean value and ${\pm}2SD$ for the difference between Cr-51 EDTA 2 samples and 6 samples were 4.7 mL/min and ${\pm}9.3$ respectively. Conclusions: The estimation of two samples Cr-51 EDTA showed that the method can be simplified by reducing blood samples without losing its high accuracy.

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