Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
권호 표지
DOI QR코드

DOI QR Code

Anti-Hyperalgesic Effects of Meloxicam Hydrogel via Phonophoresis in Acute Inflammation in Rats; Comparing Systemic and Topical Application

  • Kim, Tae-Youl (Department of Physical Therapy, Dongshin University) ;
  • Kim, Young-Il (Department of Pharmaceutical Engineering, Konyang University) ;
  • Seo, Sam-Ki (Department of Physical Therapy, Graduate School, Seonam University) ;
  • Kim, Soo-Hyeun (Department of Physical Therapy, Dongshin University) ;
  • Yang, Kyu-Ho (School of Dentistry, Dental Research Institute and Second Stage BK 21) ;
  • Shin, Sang-Chul (College of Pharmacy, Chonnam National University)
  • Published : 2009.07.31
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of this study was to determine if a meloxicam hydrogel could be administered in vivo via phonophoretic transdermal delivery using pulsed ultrasound by examining its anti-hyperalgesic effects in a rat carrageenan inflammation model. Carrageenan (1%) was injected into the plantar surface of the right hindpaw, and meloxicam hydrogel was administered via phonophoretic transdermal delivery. Changes in the mechanical and thermal hyperalgesia, as well as swelling, showed that phonophoretic delivery of meloxicam exhibited significantly better anti-hyperalgesic and anti-inflammatory effects than pulsed ultrasound. Topical and systemic application of meloxicam hydrogel using phonophoresis showed similar anti-hyperalgesic effects. These findings suggest that the transdermal administration of a meloxicam hydrogel using phonophoresis by pulsed ultrasound might be useful for treating acute inflammation.

Keywords

References

  1. Abramson, S. B. and Weissmann, G. (1989). The mechanisms of action of nonsteroidal anti-inflammatory drugs. Arthritis. Rheum. 32, 1-9 https://doi.org/10.1002/anr.1780320102
  2. Bare, A. C., Mcanaw, M. B., Pritchard, A. E., Struebing, J. G., Smutok, M. A., Christie, D. S., Domenech, M. A., Bare, M. A., Bloodworth, M. L. and Seal, L. A. (1996). Phonophoretic delivery of 10% hydrocortisone through the epidermis of humans as determined by serum cortisol concentrations. Phys. Ther. 76, 738-745; discussion 746-749. https://doi.org/10.1093/ptj/76.7.738
  3. Bommannan, D., Okuyama, H., Staufer, P. and Guy, R. H. (1992). Sonophoresis, I: the use of high frequency ultrasound to enhance transdermal drug delivery. Pharm. Res. 9, 559-564 https://doi.org/10.1023/A:1015808917491
  4. Byl, N. N. (1995). The use of ultrasound as an enhancer for transcutaneous drug delivery: phonophoresis. Phys. Ther. 75, 539-553 https://doi.org/10.1093/ptj/75.6.539
  5. Cagnie, B., Vinck, E., Rimbaut, S. and Vanderstraeten, G. (2003). Phonophoresis versus topical application of ketoprofen: comparison between tissue and plasma levels. Phys. Ther. 83, 707-712
  6. Carter, R., Ebner, D., Brenner, D. and Bruppacher, R. (1997). Use of topical NSAIDs in patients receiving systemic NSAID treatment: A pharmacy-based study in Germany. J. Clinical. Epidemiology. 50, 217-218 https://doi.org/10.1016/S0895-4356(96)00299-5
  7. Cesare, P. and Mcnaughton, P. (1997). Peripheral pain mechanisms. Curr. Opin. Neurobiol. 7, 493-499 https://doi.org/10.1016/S0959-4388(97)80028-1
  8. Chen, X., Tanner, K. and Levine, J. D. (1999). Mechanical sensitization of cutaneous C-fiber nociceptors by prostaglandin E2 in the rat. Neurosci. Lett. 267, 105-108 https://doi.org/10.1016/S0304-3940(99)00345-6
  9. Choi, S. J., Yoon, S. W., Jung, D. I., Kim, Y. I., Jeong, J. G. and Kim, T. Y. (2006). Skin permeation effects of meloxicam gel on ultrasound parameters by phonophoresis. J. Korean Acad. Clin. Electrophysiology. 4, 49-61
  10. Ciccone, C. D., Leggin, B. G. and Callamaro, J. (1991). Effects of ultrasound and trolamine salicylate phonophoresis on delayed-onset muscle soreness. Phys. Ther. 71, 666-678 https://doi.org/10.1093/ptj/71.9.666a
  11. Cui, L., Hou, X., Jiang, J., Li, G., Liang, Y. and Xin, X. (2008). Comparative enhancing effects of electrical treatment with chemical enhancers on transdermal delivery of meloxicam in vitro. pp. 12-15. Institute of Physics Publishing, London
  12. Dirig, D. M., Isakson, P. C. and Yaksh, T. L. (1998). Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats. J. Pharmacol. Exp. Ther. 285, 1031-1038
  13. Dowdall, T., Robinson, I., and Meert, T. F. (2005). Comparison of five different rat models of peripheral nerve injury. Pharmacol. Biochem. Behav. 80, 93-108 https://doi.org/10.1016/j.pbb.2004.10.016
  14. Fang, J. Y., Fang, C. L., Hong, C. T., Chen, H. Y., Lin, T. Y. and Wei, H. M. (2001). Capsaicin and nonivamide as novel skin permeation enhancers for indometacin. Eur. J. Pharm. Sci. 12, 195-203 https://doi.org/10.1016/S0928-0987(00)00118-4
  15. Feltenstein, M. W., Schuhly, W., Warnick, J. E., Fischer, N. H. and Sufka, K. J. (2004). Anti-inflammatory and anti- hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear's foot. Pharmacol. Biochem. Behav. 79, 299-302 https://doi.org/10.1016/j.pbb.2004.08.008
  16. Ferreira, S. H. (1980). Peripheral analgesia: mechanism of the analgesic action of aspirin-like drugs and opiate-antagonists. Br. J. Clin. Pharmacol. 10(Suppl 2), 237S-245S https://doi.org/10.1111/j.1365-2125.1980.tb01806.x
  17. Foldvari, M. (2000). Non-invasive administration of drugs through the skin: challenges in delivery system design. Pharm. Sci. Technol. 3, 417-425 https://doi.org/10.1016/S1461-5347(00)00317-5
  18. Francischi, J. N., Chaves, C. T., Moura, A. C., Lima, A. S., Rocha, O. A., Ferreira-Alves, D. L. and Bakhle, Y. S. (2002). Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation. Br. J. Pharmacol. 137, 837-844 https://doi.org/10.1038/sj.bjp.0704937
  19. Gajraj, N. M. (2003). Cyclooxygenase-2 inhibitors. Anesth. Analg. 96, 1720-1738.
  20. Gao, J. Q., Wang, H., Liang, W. Q. and Chen, M. X. (2002). Transdermal delivery of diclofenac sodium gel after iontophoresis. Zhejiang Da Xue Xue Bao Yi Xue Ban 31, 437-439
  21. Guffey, J. S. and Knaust, M. L. (1997). The use and efficacy of ultrasound. Rehab. Manag. 10, 44, 48-50
  22. Herrero, J. F., Parrado, A. and Cervero, F. (1997). Central and peripheral actions of the NSAID ketoprofen on spinal cord nociceptive reflexes. Neuropharmacology. 36, 1425-1431 https://doi.org/10.1016/S0028-3908(97)00120-2
  23. Hsieh, Y. L. (2006). Effects of ultrasound and diclofenac phonophoresis on inflammatory pain relief: suppression of inducible nitric oxide synthesis in arthritic rats. Phys. Ther. 86, 39-49 https://doi.org/10.1093/ptj/86.1.39
  24. Jadoul, A., Bouwstra, J. and Preat, V. (1999). Effects of iontophoresis and electroporation on the stratum corneum Review of the biophysical studies. Advanced Drug Delivery Reviews. Adv. Drug. Deliv. Rev. 35, 89-105 https://doi.org/10.1016/S0169-409X(98)00065-9
  25. Jett, M. F., Ramesha, C. S., Brown, C. D., Chiu, S., Emmett, C., Voronin, T., Sun, T., O'yang, C., Hunter, J. C., Eglen, R. M. and Johnson, R. M. (1999). Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. J. Pharmacol. Exp. Ther. 288, 1288-1297
  26. Kozanoglu, E., Basaran, S., Guzel, R. and Guler-Uysal, F. (2003). Short term efficacy of ibuprofen phonophoresis versus continuous ultrasound therapy in knee osteoarthritis. Swiss. Med. Wkly. 133, 333-338
  27. Levy, L. (1969). Carrageenan paw edema in the mouse. Life Sci. 8, 601-606 https://doi.org/10.1016/0024-3205(69)90021-6
  28. Lim, E. J., Kang, H. J., Jung, H. J., Kim, K. H.. Lim, C. J. and Park, E. H. (2008). Anti-inflammatory, anti-angiogenic and anti-nociceptive activities of 4-hydroxybenzaldehyde. Biomol. Therap. 16, 231-236 https://doi.org/10.4062/biomolther.2008.16.3.231
  29. Median, V. M., Walmsley, A. D. and Irwin, W. J. (1995). Phonophoresis - is it a reality? Int. J. Pharm. 118, 129-149 https://doi.org/10.1016/0378-5173(94)00371-B
  30. Mishra, D. N. and Vijaya Kumar, S. G. (2006). Investigations on analgesic, anti-inflammatory and ulcerogenic potential of meloxicam solid dispersion prepared with skimmed milk. Yakugaku Zasshi. 126, 495-498 https://doi.org/10.1248/yakushi.126.495
  31. Needleman, P., Turk, J., Jakschik, B. A., Morrison, A. R. and Lefkowith, J. B. (1986). Arachidonic acid metabolism. Annu. Rev. Biochem. 55, 69-102. https://doi.org/10.1146/annurev.bi.55.070186.000441
  32. Nyborg, W. L. (1985). Mechanisms. In Biological Effects of Ultrasound (W. L. Nyborg and M. C. Ziskin, Eds.), pp. 23-33. Churchill Livingstone Inc., NY
  33. Penzes, T., Blazso, G., Aigner, Z., Falkay, G. and Eros, I. (2005). Topical absorption of piroxicam from organogels--in vitro and in vivo correlations. Int. J. Pharm. 298, 47-54 https://doi.org/10.1016/j.ijpharm.2005.03.013
  34. Riviere, J. E. and Heit, M. C. (1997). Electrically-assisted transdermal drug delivery. Pharm. Res. 14, 687-697 https://doi.org/10.1023/A:1012129801406
  35. Rolf, C., Engstrom, B., Beauchard, C., Jacobs, L. D. and Le Liboux, A. (1999). Intra-articular absorption and distribution of ketoprofen after topical plaster application and oral intake in 100 patients undergoing knee arthroscopy. Rheumatology (Oxford). 38, 564-567 https://doi.org/10.1093/rheumatology/38.6.564
  36. Romsing, J., Mysager, S., Vilmann, P., Sonne, J., Larsen, N. E. and Stergaard, D. (2001). Postoperative analgesia is not different after local vs systemic administration of meloxicam in patients undergoing inguinal hernia repair. Can. J. Anesth. 48, 978-984 https://doi.org/10.1007/BF03016587
  37. Rosim, G. C., Barbieri, C. H., Lancas, F. M. and Mazzer, N. (2005). Diclofenac phonophoresis in human volunteers. Ultrasound. Med. Biol. 31, 337-343 https://doi.org/10.1016/j.ultrasmedbio.2004.11.012
  38. Schrier, D. J., Moniot, S., Gluckman, M. I. and Gibertson, R. B. (1987). The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice. J. Pharm. Pharmacol. 39, 57
  39. Sekiguchi, M., Shirasaka, M., Konno, S. and Kikuchi, S. (2008). Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model. BMC Musculoskelet Disord. 9, 15 https://doi.org/10.1186/1471-2474-9-15
  40. Tyle, P. and Agrawala, P. (1989). Drug delivery by phonophoresis. Pharm. Res. 6, 355-359 https://doi.org/10.1023/A:1015967012253
  41. Todd, P. A. and Sorkin, E. M. (1988). Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 35, 244-285 https://doi.org/10.2165/00003495-198835030-00004
  42. Tyle, P. and Agrawala, P. (1989). Drug delivery by phonophoresis. Pharm. Res. 6, 355-361 https://doi.org/10.1023/A:1015967012253
  43. Vane, J. R. (1971). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New. Biol. 231, 232-235 https://doi.org/10.1038/newbio231232a0
  44. Vlak, T. (1999). Comparative study of the efficacy of ultrasound and sonophoresis in the treatment of painful shoulder syndrome. Reumatizam. 46, 5-11
  45. Wells, P. N. (1977). Ultrasonics in medicine and biology. Phys. Med. Biol. 22, 629-669 https://doi.org/10.1088/0031-9155/22/4/001
  46. Xin, B., Yokoyama, Y., Shigeto, T., Futagami, M. and Mizunuma, H. (2007). Inhibitory effect of meloxicam, a selective cyclooxygenase-2 inhibitor, and ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, on the growth of human ovarian cancers. Cancer 110, 791-800 https://doi.org/10.1002/cncr.22854
  47. Yang, J. H., Kim, D. K., Kim, T. Y., Kim, G. Y. and Shin, S. C. (2005). Anti-inflammatory effects by transdermal application of triamcinolone acetonide gel using phonophoresis in rats. Int. J. Pharm. 302, 39-46 https://doi.org/10.1016/j.ijpharm.2005.06.011
  48. Yang, J. H., Kim, T. Y., Lee, J. H., Yoon, S. W., Yang, K. H. and Shin, S. C. (2008). Anti-hyperalgesic and anti-inflammatory effects of ketorolac tromethamine gel using pulsed ultrasound in inflamed rats. Arch. Pharm. Res. 31, 511-517 https://doi.org/10.1007/s12272-001-1186-5
  49. Yocum, D., Fleischmann, R., Dalgin, P., Caldwell, J., Hall, D. and Roszko, P. (2000). Safety and efficacy of meloxicam in the treatment of osteoarthritis: a 12-week, double-blind, multiple-dose, placebo-controlled trial. The meloxicam osteoarthritis investigators. Arch. Intern. Med. 160, 2947-2954 https://doi.org/10.1001/archinte.160.19.2947

Cited by

  1. Strategies for meloxicam delivery to and across the skin: a review vol.23, pp.8, 2016, https://doi.org/10.3109/10717544.2016.1157839
  2. Fabrication of Tip-Dissolving Microneedles for Transdermal Drug Delivery of Meloxicam vol.19, pp.3, 2018, https://doi.org/10.1208/s12249-017-0926-7