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http://dx.doi.org/10.4062/biomolther.2009.17.3.305

Anti-Hyperalgesic Effects of Meloxicam Hydrogel via Phonophoresis in Acute Inflammation in Rats; Comparing Systemic and Topical Application  

Kim, Tae-Youl (Department of Physical Therapy, Dongshin University)
Kim, Young-Il (Department of Pharmaceutical Engineering, Konyang University)
Seo, Sam-Ki (Department of Physical Therapy, Graduate School, Seonam University)
Kim, Soo-Hyeun (Department of Physical Therapy, Dongshin University)
Yang, Kyu-Ho (School of Dentistry, Dental Research Institute and Second Stage BK 21)
Shin, Sang-Chul (College of Pharmacy, Chonnam National University)
Publication Information
Biomolecules & Therapeutics / v.17, no.3, 2009 , pp. 305-310 More about this Journal
Abstract
The aim of this study was to determine if a meloxicam hydrogel could be administered in vivo via phonophoretic transdermal delivery using pulsed ultrasound by examining its anti-hyperalgesic effects in a rat carrageenan inflammation model. Carrageenan (1%) was injected into the plantar surface of the right hindpaw, and meloxicam hydrogel was administered via phonophoretic transdermal delivery. Changes in the mechanical and thermal hyperalgesia, as well as swelling, showed that phonophoretic delivery of meloxicam exhibited significantly better anti-hyperalgesic and anti-inflammatory effects than pulsed ultrasound. Topical and systemic application of meloxicam hydrogel using phonophoresis showed similar anti-hyperalgesic effects. These findings suggest that the transdermal administration of a meloxicam hydrogel using phonophoresis by pulsed ultrasound might be useful for treating acute inflammation.
Keywords
Meloxicam hydrogel; Phonophoretic transdermal delivery; Anti-hyperalgesia; Systemic application; Topical application; Acute inflammation;
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