Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Attenuated Cerebral Ischemic Injury by Polyethylene Glycol-Conjugated Hemoglobin

  • Cho, Geum-Sil (Department of Neuroscience, College of Medicine, Korea University) ;
  • Choi, In-Young (Department of Neuroscience, College of Medicine, Korea University) ;
  • Choi, Yoo-Keum (Department of Neuroscience, College of Medicine, Korea University) ;
  • Kim, Seul-Ki (Department of Neuroscience, College of Medicine, Korea University) ;
  • Cai, Ying (Department of Neuroscience, College of Medicine, Korea University) ;
  • Nho, Kwang (SunBio Inc.) ;
  • Lee, Jae-Chul (Clinical Research Institute, Seoul National University Hospital)
  • Published : 2009.07.31
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Abstract

Polyethylene glycol-conjugated hemoglobin (PEG-Hb) has been proposed as a blood substitute for transfusion due to their plasma expansion and oxygen transport capabilities. The protective effect of PEG-Hb on cerebral hypoxic-ischemic injury was investigated in neonatal hypoxia model and adult rat focal cerebral ischemia model. As intravenously administered 30 min before the onset of hypoxia, PEG-Hb markedly protected cerebral hypoxic injury in a neonatal rat hypoxia model. A similar treatment of PEG-Hb largely reduced the ischemic injury ensuing after 2-h middle cerebral artery occlusion followed by 22-h reperfusion. Consistently, neurological disorder was significantly improved by PEG-Hb. The results indicate that the pharmacological blockade of cerebral ischemic injury by using PEG-Hb may provide a useful strategy for the treatment of cerebral stroke.

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References

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