The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Inhibitory Effect of Dendrobium moniliforme on NO and IL-$1{\beta}$ Production in LPS-stimulated Macrophages

LPS로 자극된 대식세포에서 석곡의 NO 및 IL-$1{\beta}$ 생성 억제 효과

  • Park, Ga-Young (Department of Molecular Biology, College of Natural Sciences, Pusan National University) ;
  • Bae, Chang-Hwan (Department of Molecular Biology, College of Natural Sciences, Pusan National University) ;
  • Park, Sun-Young (Department of Molecular Biology, College of Natural Sciences, Pusan National University) ;
  • Kim, Ji-Hee (Department of Molecular Biology, College of Natural Sciences, Pusan National University) ;
  • Ko, Woo-Shin (Department of Oriental Medicine, College of Oriental Medicine, Dongeui University) ;
  • Kim, Young-Hee (Department of Molecular Biology, College of Natural Sciences, Pusan National University)
  • 박가영 (부산대학교 자연과학대학 분자생물학과) ;
  • 배창환 (부산대학교 자연과학대학 분자생물학과) ;
  • 박순영 (부산대학교 자연과학대학 분자생물학과) ;
  • 김지희 (부산대학교 자연과학대학 분자생물학과) ;
  • 고우신 ;
  • 김영희 (부산대학교 자연과학대학 분자생물학과)
  • Received : 2009.11.27
  • Accepted : 2009.12.05
  • Published : 2009.12.25
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Abstract

석곡은 난초과의 여러해살이풀 Dendrobium moniliforme의 지상부를 건조한 것으로 예로부터 양위생진(養胃生津), 자음제열(滋陰除熱) 등의 효능이 있어 해열, 진통의 작용과 위액분비 촉진, 혈압강하의 작용이 있는 것으로 알려져 있다. 본 연구에서는 석곡의 항염증 작용 기전을 알아보기 위하여 석곡 열수추출물을 대식세포주에 처리하여 NO 및 IL-$1{\beta}$의 생성에 미치는 영향을 조사하였다. LPS로 자극된 대식세포주 RAW264.7 세포에서 석곡은 NO 및 IL-$1{\beta}$ 생성과 iNOS 단백질 발현을 저해하였으며, LPS에 의해서 활성화되는 ERK, p38, JNK 효소의 활성을 현저히 억제하였다. 이 결과들로 보아 석곡의 항염증 작용이 MAPK 활성 저해로 인한 NO 및 IL-$1{\beta}$ 생성의 억제 때문인 것으로 사료된다.

Keywords

References

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