DOI QR코드

DOI QR Code

심박동수 및 관상동맥 석회화가 64 절편 다중검출기 심장 CT의 관상동맥 질환 진단일치도에 미치는 영향

The Influence of Heart Rate and Coronary Calcification on the Diagnostic Accuracy of 64-slice Multidetector Cardiac CT in Coronary Artery Disease

  • 강영한 (대구가톨릭대학교병원 영상의학과) ;
  • 박종삼 (대구보건대학 방사선과)
  • 투고 : 2009.08.31
  • 심사 : 2009.11.06
  • 발행 : 2009.12.28

초록

연구목적: 64 절편 MDCT를 이용한 심장 CT의 진단일치도를 알아보고, 심박동수와 관상동맥 석회화가 진단일치도에 영향을 미치는지 확인하여 심장 CT 검사 시 기초 자료로 활용하고자 함이다. 연구방법: 심장 CT와 관상동맥 조영술을 함께 시행한 178명(남자 84명, 여자 94명)을 대상으로 심장 CT에서 관상동맥 협착과 심박동수, 석회화 수치를 측정하였고, 관상동맥조영술에서 좌전하행동맥, 좌회선동맥, 우관상동맥의 유의한 협착($\geq50%$)이 있는지 확인하였다. 관상동맥 조영술의 결과를 표준으로 심장 CT의 민감도, 특이도, 양성예측도, 음성예측도, kappa index($\kappa$)를 계산하였다. 연구결과: 환자별 협착의 정도를 평가한 결과 심장 CT의 정확도는 96.6%였다. 혈관별로는 LAD, LCX, RCA 각각 86.5%, 84.3%, 92.1%로 높은 진단일치도를 보였다. 체질량지수와 혈압은 심장 CT의 진단일치도에 영향을 미치지 않았다. 심박동수는 60/min 미만에서 정확도 90.1%, $\kappa$값 0.78이었고, 70/min 이상에서는 정확도가 75.8%, $\kappa$값 0.52이었다. 관상동맥 석회화지수 100 미만에서는 정확도가 91.3%, $\kappa$값 0.81이었고, 석회화지수 400 이상에서는 정확도 68.6%, $\kappa$값 0.33으로 떨어졌다. 결론: 64 절편 MDCT를 이용한 심장 CT는 관상동맥 조영술과 거의 비슷한 진단일치도를 나타냈다. 하지만 심박동수 70/min 이상, 관상동맥 석회화지수 400 이상에서는 진단일치도가 저하되었기 때문에 심장 CT 검사 시 심박동수와 관상동맥 석회화지수를 확인하여 검사하여야 하고, 심박동수가 70/min 이상이면 베타차단제를 사용하여 심박동수를 조절하여야 한다.

Purpose : This study was to investigate the influence of heart rate and coronary calcification on diagnostic accuracy of 64-slice multidetector CT(MDCT) in coronary artery disease. Methods : 178 patients(84 men, 94 women) undergoing cardiac CT were included in this study. 3 coronary arteries(LAD, LCX, RCA) were assessed the presence of significant stenosis($\geq50%$) and the results compared with those of coronary angiography. Results : On a patient-based analysis, the diagnostic accuracy of 64-slice MDCT was 96.6%. The diagnostic accuracy on left anterior descending, left circumflex, right coronary artery were 86.5%, 84.3%, 92.1% respectively. Body mass index and blood pressure were not influenced on diagnostic accuracy of 64-slice MDCT. In less than 60/min of heart rate, accuracy was 90.1% and $\kappa$ value was 0.78. While in more than 70/min of heart rate, accuracy was 75.8% and $\kappa$ value was 0.52. In less than 100 of coronary calcification, accuracy was 91.3% and $\kappa$ value was 0.81. While in more than 400, accuracy was 68.6% and $\kappa$ value was 0.33. Conclusion : 64-slice MDCT shows similar diagnostic accuracy as coronary angiography. But in the context of more than 70/min of heart rate and 400 of coronary calcification, diagnostic accuracy was decreased. So there needs to identify heart rate and coronary calcification in cardiac CT, and if heart rate shows more than 70/min, use beta-blocker to regulate it.

키워드

참고문헌

  1. K. Klingenbeck-Regn, S. Schaller, T. Flohr, B. Ohnesorge, A. F. Kopp, and U. Baum, "Subsecond multi-slice computed tomography: basics and application," Eur J Radiol, Vol.31, No.2, pp.110-124, 1999. https://doi.org/10.1016/S0720-048X(99)00086-8
  2. B. Ohnesorge, T. Flohr, and C. Becker, "Cardiac imaging by means of electrocardio -graphically gated multisection spiral CT: initial experience," Radiology, Vol.217, No.2, pp.564-571, 2000. https://doi.org/10.1148/radiology.217.2.r00nv30564
  3. P. J. Scanlon, D. P. Faxon, A. M. Audet, B. Carabello, G. J. Dehmer, G. J. Dehmer, and et al, "ACC/AHA guidelines for coronary angiography. A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on Coronary Angiography). Developed in collaboration with the Society for Cardiac Angiography and Interventions," J AM Coll, Vol.33, No.6, pp.1756-1824, 1999. https://doi.org/10.1016/S0735-1097(99)00126-6
  4. K. Nieman, M. Oudkerk, and B. J. Rensing, "Coronary angiography with multislice computed tomography," Lancet, Vol.357, pp.599-603, 2001. https://doi.org/10.1016/S0140-6736(00)04058-7
  5. D. Ropers, U. Baum, and K. Pohle, "Detection of coronary artery stenosis with thin-slice multi-detector row spiral computed tomography and multiplanar reconstruction," Circulation, Vol.107, No.5, pp.664-666, 2003. https://doi.org/10.1161/01.CIR.0000055738.31551.A9
  6. T. Giesler, U. Baum, D. Ropers, S. Ulzheimer, E. Wenkel, M. Mennicke, and et al. "Noninvasive visualization of coronary arteries using contrast-enhanced multidetector CT: influence of heart rate on image quality and stenosis detection," AJR Am J Roentgenol, Vol.179, No.4, pp.911-916, 2002. https://doi.org/10.2214/ajr.179.4.1790911
  7. 강동원, 김현수, 박성옥, 박종삼, 유병현, 이경숙, "Computed Tomography", 대학서림, pp.203-209, 2007.
  8. P. J. De Fevter, W. B. Meijboom, A. Weustink, Van Mieghem C, Mollet NR, Vourvouri E, and et al. "Spiral multislice computed tomography coronary angiography: a current status report," Clin Cardiol, Vol.30, No.9, pp.437-442, 2007. https://doi.org/10.1002/clc.16
  9. Z. Sun and W. Jiang, "Diagnostic value of multislice computed tomography angiography in coronary artery disease: A meta-analysis," Eur J Radiol, Vol.60, No.2, pp.279-286, 2006. https://doi.org/10.1016/j.ejrad.2006.06.009
  10. 남궁준, 최현민, 권성욱, 도준형, 이성윤, 허감 등, "64절편 다검출기 CT 관상동맥 조영술을 이용한 관상동맥 질환 진단의 정확도", 대한내과학회지, 제75권, 제1호, pp.42-53, 2008.
  11. C. Burgstahler, T. Beck, A. Kuettner, A. Reimann, A. F. Kopp, H. Heuschmid, and et al. "Image quality and diagnostic accuracy of 16-slice multidetector computed tomography for the detection of coronary artery disease in obese patients," Int J Obes(Lond), Vol.30, No.3, pp.569-573, 2006. https://doi.org/10.1038/sj.ijo.0803157
  12. G. L. Raff, M. J. Gallagher, W. W. O'Neill, and J. A. Goldstein, "Diagnostic accuracy of noninvasive coronary angiography using 64-slice spiral computed tomography," J Am Coll Cardiol, Vol.46, No.3, pp.552-557, 2005. https://doi.org/10.1016/j.jacc.2005.05.056
  13. D. Ropers, U. Baum, K. Pohle, K. Anders, S. Ulzheimer, B. Ohnesorge, and et al. "Detection of coronary artery stenosis with thin slice multidetector row spiral computed tomography and multiplanar reconstruction," Circulation, Vol.107, pp.664-666, 2003 https://doi.org/10.1161/01.CIR.0000055738.31551.A9
  14. P. Stolzmann, H. Scheffel, S. Leschka, A. Plass, S. Baumuller, and B. Marincek, "Influence of calcifications on diagnostic accuracy of coronary CT angiography using prospective ECG triggering," AJR Am J Roentgenol, Vol.191, No.6, pp.1684-1689, 2008. https://doi.org/10.2214/AJR.07.4040
  15. L. Meng, L. Cui, Y. Cheng, X. Wu, Y. Tang, and Y. Wang, "Effect of heart rate and coronary calcification on the diagnostic accuracy of the dual-source CT coronary angiography in patients with suspected coronary artery disease," Korean J Radiol, Vol.10, No.4, pp.347-354, 2009. https://doi.org/10.3348/kjr.2009.10.4.347