Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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A Case of Seizure in Diphenhydramine Overdose

디펜히드라민 음독 후 경기를 주소로 응급센터에 내원한 환자 1례

  • Park, Jung-Soo (Department of Emergency Medicine,, College of Medicine, Chungbuk National University) ;
  • Kim, Hoon (Department of Emergency Medicine,, College of Medicine, Chungbuk National University) ;
  • Lee, Suk-Woo (Department of Emergency Medicine,, College of Medicine, Chungbuk National University)
  • 박정수 (충북대학교 의과대학 응급의학교실) ;
  • 김훈 (충북대학교 의과대학 응급의학교실) ;
  • 이석우 (충북대학교 의과대학 응급의학교실)
  • Published : 2009.06.12
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Abstract

A 21-year-old woman ingested 1,250 mg of diphenhydramine in a single overdose. Diphenhydramine, a rare ingredient in over-the-counter medication, is used to treat insomnia in Korea. Toxicity is usually limited to anticholinergic symptoms. The standard approach to therapy for the treatment of diphenhydramine overdose is supportive care, including physostigmines and sodium bicarbonates. Here, we review the literature and for the first time report a case of acute diphenhydramine overdosage in Korea, complicated with seizures.

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