Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
권호 표지

Current Uses and Research Activity Regarding Non-testing Methods Including (Q)SARs in Various Chemical Regulatory Programs

국외 화학물질 관리 제도 내에서의 (Q)SARs 및 비-시험 방법 사용과 관련 연구 현황

  • Ha, Mi-Hee (Knowledge Research Group, KIST Europe Forschungsgesellschaft mbH, Saarlandes University) ;
  • Kim, Sang-Hun (Knowledge Research Group, KIST Europe Forschungsgesellschaft mbH, Saarlandes University)
  • 하미희 (한국과학기술연구원 유럽연구소, 지식연구그룹) ;
  • 김상헌 (한국과학기술연구원 유럽연구소, 지식연구그룹)
  • Published : 2009.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

To make measurable regulatory decisions of chemicals, it is necessary to consider their effect on the human health and ecosystem. In principle, this is based on relevant toxicity studies conducted by accepted guidelines. However, current regulatory programs in various countries confront challenges related to risk assessment of large numbers of chemicals within the restricted resources and time. Therefore there is a need for more efficient approach to limit the number of tests to be conducted. This promotes the development of powerful nontesting methods (e.g. (Q)SARs) and permits to use the predicted data for regulatory purpose. In this article, current status of non-testing methods in various chemical regulatory programs was reviewed in terms of their application and research activity on them. Finally, their usefulness associated with development of domestic regulatory program was suggested.

Keywords

References

  1. Dix DJ, Houck KA, Martin MT, Richard AM, Setzer RW and Kavlock RJ. The ToxCast program for prioritizing toxicity testing of environmental chemicals, Toxicol Sci 2007; 95: 5-12 https://doi.org/10.1093/toxsci/kfl103
  2. EC (Environment Canada). Environment Canada. Existing substances evaluation, 2005
  3. EC (European Commission). Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes, 1986
  4. EC(European Commission). Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Regulation (EC) No 1907/2006 of the European Parliament and of the Council, 2006
  5. ECB (European Chemical Bureau). Three point three-A Project for the Information Requirements of REACH. Lot 3: Scoping study on the Development of a Technical Guidance Document on Information requirements on Intrinsic Properties of Substances (RIP 3.3-1), 2005
  6. Kroese ED. Feasibility of non-testing approaches in human health assessment. Toxicol Lett 2008; 180: S17
  7. Nendza M and Hermens JLM. Properties of chemicals and estimation methodologies. In: Risk Assessment of Chemicals. An Introduction (van Leeuwen CJ and Hermens JLM, eds). Dordrecht:Kluwer Academic Publishers, 1995; 239-292
  8. NITE (National Institute of Technology and Evaluation). Biodegradation and bioconcentration database of the Existing Chemical Substances, 2006
  9. NRC (National Research Council). Toxicity testing in the 21st Century: A vision and a Strategy. Washington, DC; National Academy Press, 2007
  10. OECD(Organisation for Economic Co-operation and Development). Report of the OECD Workshop on Application of Quantitative Structure Activity Relationships (QSARs) in Aquatic Effects Assessment, OECD Environment Monographs, no 58. Paris: Organisation for Economic Cooperationand Development, 1992
  11. OECD(Organisation for Economic Co-operation and Development). Guidance document on the validation on the validation of (Quantitative) Structure-Activity Relationships [(Q)SAR] models, 2007
  12. OECD(Organisation for Economic Co-operation and Development). Overview of the OECD (Q)SAR Application Toolbox, 2008
  13. Pavan M and Worth AP. Publicly-accessible QSAR software tools developed by the Joint Research Centre, SAR QSAR Environ Res 2008; 19: 785-799 https://doi.org/10.1080/10629360802550390
  14. US EPA (United States Environmental Protection Agency). TSCA New Chemicals Program (NCP) Chemical Categories, 2002
  15. Zeeman M, Auer CM, Clements RG, Nabholz JV and Boethling RS. US EPA regulatory perspectives on the use of (Q)SAR for new and existing chemical evaluations, SAR QSAR Environ Res 1995; 3: 179-201 https://doi.org/10.1080/10629369508234003