Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
권호 표지
DOI QR코드

DOI QR Code

Preparation and evaluation of microcrystallized cellulose xanthate-metal-oxytetracycline complexes as antibacterial agents with prolonged antibacterial activity

  • Kong, Hyo-Sik (Laboratory of Biomedicinal/Medicinal Chemistry, College of Pharmacy, Pusan National University) ;
  • Lee, You-Na (Laboratory of Biomedicinal/Medicinal Chemistry, College of Pharmacy, Pusan National University) ;
  • Lee, Yong-Hyun (Laboratory of Biomedicinal/Medicinal Chemistry, College of Pharmacy, Pusan National University) ;
  • Kim, Young-Mi (Laboratory of Biomedicinal/Medicinal Chemistry, College of Pharmacy, Pusan National University) ;
  • Jung, Yun-Jin (Laboratory of Biomedicinal/Medicinal Chemistry, College of Pharmacy, Pusan National University)
  • Published : 2009.04.27
Download PDF
⟨ Previous Next ⟩

Abstract

Microcrystallized cellulose xanthate-metal-oxytetracycline complexes (MCX-metal-OTC) were prepared and evaluated as a controlled release system for the antibiotics. Microcrystallized cellulose (MC) was chemically modified to xanthated microcrystallized cellulose (MCX). One-bath method, where MCX was reacted with OTC-metal complexes, afforded greater amount of OTC bound to the polymeric matrix than did two-bath method, where MCX-metal complexes were treated with OTC. The OTC release from MCX-metal-OTC was greatly sustained compared with that from a mixture of MC/metal/OTC. Furthermore, MCX-metal-OTC manifested antibacterial activity, which lasted for 11-18 days. These results suggest that MCX-metal-OTC is a polymeric antibiotics with prolonged antibacterial activity.

Keywords

References

  1. H. D. Smyth, A Review of: “Polymeric Drug Delivery Systems”, Drug Dev. Ind. Pharm., 32(9), 1111 (2006). https://doi.org/10.1080/03639040600599913
  2. F. M. Veronese and M. Morpurgo, Bioconjugation in pharmaceutical chemistry, Farmaco, 54(8), 497-516 (1999). https://doi.org/10.1016/S0014-827X(99)00066-X
  3. R. B. Greenwald, C. D. Conover and Y. H. Choe, Poly(ethyleneglycol) conjugated drugs and prodrugs: a comprehensive review, Crit. Rev. Ther. Drug. Carrier Syst., 17(2), 101-161 (2000).
  4. K. Hoste, K. De Winne and E. Schacht, Polymeric prodrugs, Int J Pharm, 277(1-2), 119-131 (2004). https://doi.org/10.1016/j.ijpharm.2003.07.016
  5. O. Andersen, Chemical and biological considerations in the treatment of metal intoxications by chelating agents, Mini Rev. Med. Chem., 4(1), 11-21 (2004). https://doi.org/10.2174/1389557043487583
  6. N. J. Ha, Y. J. Jung, J. S. Lee, Y. T. Kim and Y. M. Kim, Formation, properties and antimicrobial activities of cotton xanthate- Cu(II)-homosulfamine complex, Arch. Pharm. Res., 21(5), 570-575 (1998). https://doi.org/10.1007/BF02975377
  7. Y. Jung and Y. M. Kim, Evaluation of cellulose xanthatemetal-tetracycline complexes as a polymeric antibacterial agent with prolonged antibacterial activity, Drug Deliv., 15(1), 31-35 (2008). https://doi.org/10.1080/10717540701828723
  8. M. C. Carson, G. Bullock and J. Bebak-Williams, Determination of oxytetracycline residues in matrixes from a freshwater recirculating aquaculture system, J. AOAC Int., 85(2), 341-348 (2002).
  9. E. V. Piletska, N. W. Turner, A. P. Turner and S. A. Piletsky, Controlled release of the herbicide simazine from computationally designed molecularly imprinted polymers, J. Control. Release, 108(1), 132-139 (2005). https://doi.org/10.1016/j.jconrel.2005.07.016
  10. G. Rigos, I. Nengas, M. Alexis and G. M. Troisi, Potential drug (oxytetracycline and oxolinic acid) pollution from Mediterranean sparid fish farms, Aquat. Toxicol., 69(3), 281-288 (2004). https://doi.org/10.1016/j.aquatox.2004.05.009