Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Hypotensive effect of BDR-29 in SHR-SP

뇌졸중 유발 고혈압 흰쥐 (SHR-SP)에서 BDR-29에 의한 혈압 강하 효과

  • Hwang, Sun-Mi (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Eun-Ju (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Hye-Yoom (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Choi, Deok-Ho (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Shin, Sun (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Yun-Jung (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kang, Dae-Gill (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 황선미 (원광대학교 한의학전문대학원) ;
  • 김은주 (원광대학교 한의학전문대학원) ;
  • 김혜윰 (원광대학교 한의학전문대학원) ;
  • 최덕호 (원광대학교 한의학전문대학원) ;
  • 신선 (원광대학교 한의학전문대학원) ;
  • 이윤정 (원광대학교 한의학전문대학원) ;
  • 강대길 (원광대학교 한의학전문대학원) ;
  • 이호섭 (원광대학교 한의학전문대학원)
  • Published : 2009.12.31
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Abstract

The purpose of this study is to investigate hypotensive effect of BDR-29, new herbal preparation of Cassiae Semen, Prunellae Spica, Uncariae Ramulus et Uncus, and Tribuli Semen, in stroke-prone spontaneously hypertensive rats (SHR-SP). SHR-SP were treated with BDR-29 at a dose of 100, 200 mg/kg/day orally for 13 weeks. In the BDR-29 treat group, mean blood pressure and systolic blood pressure were significantly reduced (p<0.05). In phenylephrine-precontracted arota and carotid artery, BDR-29 induced endothelium-dependent vascular relaxation. Hematological findings and biochemical examination revealed no evidence of specific toxicity related to BDR-29. In addition, BDR-29 was markedly attenuated intima-media thickness of thoracic aorta with progression of atherosclerosis. SHR-SP were treated with BDR-29 were significantly increased eNOS expression in arota. These results indicated that BDR-29 improves blood pressure as well as initial atherosclerotic lesion.

Keywords

References

  1. 박창규 (2006) 고혈압환자에서 뇌졸중 발병위험요인과 치료행태에 관한 연구, 대한고혈압학회지 12: 16-24
  2. Park, J. B. and Schiffrin, E. L. (2000) Effects of antihypertensive therapy on hypertensive vascular disease. Curr Hypertens Rep, 2: 280-288 https://doi.org/10.1007/s11906-000-0011-5
  3. Hsueh, W. A., Quinones, M. J. and Creager, M. A. (1997) Endothelium in insulin resistance and diabetes. Diabetes Rev, 5: 343-352
  4. Busse, R. and Fleming, I. (1993) The endothelial organ. Curr Op Cardiol, 8: 719-727 https://doi.org/10.1097/00001573-199309000-00002
  5. Vane, J. R., Anggard, E. E. and Botting, R. M. (1990) Regulatory functions of the vascular endothelium. N Engl J Med, 323: 27-36 https://doi.org/10.1056/NEJM199007053230106
  6. Gibbons, G. H. and Dzau, V. J. (1996) Molecular therapy for vascular diseases. Science, 272: 689-693 https://doi.org/10.1126/science.272.5262.689
  7. Chou, T. C., Yen, M. H., Li, C. Y. and Ding, Y. A. (1998) Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension, 31: 643-648 https://doi.org/10.1161/01.HYP.31.2.643
  8. Pitt, B., Reichek, N., Willenbrock, R., Zannad, F., Phillips, R. A., Roniker, B., Kleiman, J., Krause, S., Burns, D. and Williams, G.H. (2003) Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation, 108: 1831-1838 https://doi.org/10.1161/01.CIR.0000091405.00772.6E
  9. Akiyama, S. (2005) Blood clinical data and drug side effects that require attention during physical thereph Rigakuryoho kagaku, 20: 69-73 https://doi.org/10.1589/rika.20.69
  10. Yoshikawa, H., (2006) 高血壓治療藥 基礎, 開發中인 高血 壓治療藥. Folia Pharmacol Jpn, 127: 381-386 https://doi.org/10.1254/fpj.127.381
  11. 최현숙, 차선숙, 나명순, 신길만, 이명렬 (2001) 결명자 에탄올추출물이 알코올 투여 흰쥐의 항산화물질 및 지질대사에 미치는 영향, 한국식품영양학회지 30: 1177-1183
  12. 유헌숙, 최학주, 김선빈, 김동희 (2008) 하고초산(夏枯草散) 이 고지혈(高脂血) 유발(誘發) SHR 백서(白鼠)에 미치는 영향(影響), 한의학연구소논문집 17: 101-116
  13. 홍석 (1997) 백질려가 백서(白鼠)의 혈압(血壓)에 미치는 영향(影響), 대한한방내과학회지 18: 151-159
  14. 김은순, 장보윤, 이안숙, 강대길, 이호섭, 김병두, 김성연 (2007) 랫트에서 한약재 복합물 BDR-29의 단회 경구투여 독성에 관한 연구, 생약학회지 38: 71-75
  15. 장보윤, 강대길, 이호섭, 김성연 (2008) BDR-29의 랫트에 대한 13주 반복투여 독성에 관한 연구, 생약학회지 39: 60-67
  16. 김은주, 강대길, 이안숙, 최덕호, 조국현, 김성연, 이호섭 (2008) 혈관질환 억제 효능이 있는 BDR-29의 백서 신장 독성연구, 대한한의학 방제학회지 16: 163-169
  17. Phillips, R. A., Edited by Peter, J. P. Vanslyke, D. D., Willians and Wilkins (1994) In Quantitative Clinical Chemistry Methods. Vol. 2
  18. 이준경, 조국현, 강대길, 권태오, 권지웅, 김진숙, 손은진, 이호섭 (2006) 선학초 부탄올 추출물의 혈관 이완 효과의 기전에 대한 연구, 생약학회지 37: 67-73
  19. 송병용, 홍석, 김동희, 전상윤 (2007) 가미천마구등음이 고혈압 병태모델에 미치는 영향, 동의생리병리학회지 21: 504-510
  20. Yang, Q., Goto, H., Shimada, Y., Kita, T., Shibahara, N. and Terasawa K. (2002) Effects of Choto-san on hemorheological factors and vascular function in stroke-prone spontaneously hypertensive rats. Phytomedicine, 9: 93-98 https://doi.org/10.1078/0944-7113-00088
  21. Tahira, Y., Fukuda, N., Endo, M., Suzuki, R., Ikeda, Y., Takagi, H., Matsumoto, K. and Kanmatsuse, K. (2002) Transforming growth factor-beta expression in cardiovascular organs in stroke-prone spontaneously hypertensive rats with the development of hypertension. Hypertens Res, 25: 911-918 https://doi.org/10.1291/hypres.25.911
  22. Ju, H., Behm, D. J., Nerurkar, S., Eybye, M. E., Haimbach, R. E., Olzinski, A. R., Douglas, S. A. and Willette, R. N. (2003) p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 1. p38 MAPK-dependent endothelial dysfunction and hypertension. J Pharmacol Exp Ther, 307: 932-938 https://doi.org/10.1124/jpet.103.057422
  23. Mashina, Slu, Smirin, B. V., Malyshev, IIu, Liamina, N. P., Senchikhin, V. N., Pokidyshev, D. A. and Manukhina, E. B. (2001) Correction of NO-dependent cardiovascular disorders by adaptation to hypoxia. Ross Fiziol Zh Im I M Sechenova, 87: 110-117
  24. Zo, J. H. and Kim, C. H. (1998) Endothelium-Dependent Vasodilation Responses in the Patients with Congestive Heart Failure. Korean Circulation J 28: 1755-1759
  25. Bhan, R. D., Giacomelli, F. and Wiener, J. (1982). Adrenoreceptor blackade in angiotensin-induced hypertension: Effect on rat coronary arteries and myocardium. Am J Pathol, 108: 60-71
  26. Mancini, G. B. J. (2000). Carotid intima-media thickness as a measure of vascular target oragn damage. Curr Hypertens Reports, 2: 71-99 https://doi.org/10.1007/s11906-000-0062-7
  27. Cooke, J. P. and Dzau, V. (1997). Nitric oxide synthase: role in the genesis of vascular disease. Annu Rev Med, 48: 489-509 https://doi.org/10.1146/annurev.med.48.1.489