대한본초학회지 (The Korea Journal of Herbology)

  • 제24권4호
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  • Pages.205-213
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  • 2009
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지
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항암제 유발 신경독성을 관리하는 한의학 및 보완대체요법들과 임상시험 현황

The Present Clinical Studies of Oriental Medicine and CAM Therapies in Chemotherapy-induced Peripheral Neurotoxicity

  • 박선주 (경희대학교 한의과대학 암예방소재개발연구센터) ;
  • 고호연 (세명대학교 한의과대학 내과학교실) ;
  • 한유진 (숙명여자대학교 글로벌서비스학부) ;
  • 고성규 (경희대학교 한의과대학 예방의학교실) ;
  • 김성훈 (경희대학교 한의과대학 암예방소재개발연구센터)
  • Park, Sun-Ju (Department of Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyung Hee University) ;
  • Go, Ho-Yeon (Department of Oriental Internal Medicine, College of Oriental Medicine, Semyung University) ;
  • Han, Yoo-Jin (School of Global Service, Sookmyung Women's University) ;
  • Ko, Seong-Gyu (Department of Preventive Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Sung-Hoon (Department of Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyung Hee University)
  • 발행 : 2009.12.30
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초록

Objectives : Cancer incidence is increasing in all countries and chemotherapy-induced peripheral neuropathy (CIPN) in patients undergoing chemotherapeutic agents have been a clinically serious problems. So far therapeutic options for CIPN patients are limited and no confirmed methods have yet been established for dealing with peripheral neuropathy. Therefore this review is to provide an evidence-based summary of oriental medicine and CAM (complementary and alternative medicine) neuroprotective and treatment therapies which have gone through clinical trials. Methods : An overview of the domestic and international papers of adult clinical trials relating management of only CIPN symptoms through 1990 to present were searched by electronic databases. Search key words were chemotherapy-induced neurotoxicity, chemotherapy-induced peripheral neuropathy, chemotherapy toxicity & herb, chemotherapy toxicity & acupuncture, chemotherapy toxicity & CAM. Only English and Korean written papers were reviewed. Total 25 papers were reviewed in this study, 18 papers were retrieved by electronic search. Results : Clinical studies of managing CIPN were rare, two acupuncture clinical studies and four herb medicinal studies were found. Rest of 19 papers were about other CAM clinical studies. Total 25 papers were analyzed, and all interventions were focused on their pain control efficacy. Other 24 trials of potential therapies except one proved to be effective for CIPN, however some described to be inadequate positive or sufficient negative. Conclusions : As most of the studies were pilot studies, interventions for the prevention and treatment of CIPN have to go through prospective confirmatory studies, such as larger scale randomized, double-blinded, placebo controlled clinical trials must be done for the safe and effective use of proposed therapies. Also standard measurement scales have to be developed for the better clinical study of CIPN.

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