대한본초학회지 (The Korea Journal of Herbology)

  • 제24권4호
  • /
  • Pages.197-204
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  • 2009
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
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한약복합물 HT008이 흰쥐 관절염 모델에 미치는 효과

Effect of New Herbal Mixture, HT008 on Arthritis Rat Model

  • 임동욱 (경희대학교 한의과대학 본초학교실) ;
  • 김미연 (경희대학교 한의과대학 본초학교실) ;
  • 송미경 (경희대학교 한의과대학 본초학교실) ;
  • 김지영 (경희대학교 한의과대학 본초학교실) ;
  • 이동헌 (경희대학교 한의과대학 본초학교실) ;
  • 박주연 (뉴메드 한의과학기술연구소) ;
  • 부영민 (경희대학교 한의과대학 본초학교실) ;
  • 김호철 (경희대학교 한의과대학 본초학교실)
  • Lim, Dong-Wook (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Mi-Yeon (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Song, Mi-Kyung (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Ji-Young (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Dong-Hun (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Park, Ju-Yeon (Korea Institute of Science and Technology of East Medicine, NeuMed Co Ltd) ;
  • Bu, Young-Min (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Ho-Cheol (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University)
  • 발행 : 2009.12.30
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초록

Objectives : This study was conducted to investigate the effect of HT008, a multi-herbal mixture consisting of 3 herbs, Eleutherococcus senticosus, Angelica sinensis, and Scutellaria baicaleinsis on arthritic model in rats. Methods : The anti-inflammatory and analgesic activities were observed by utilizing the following models: carrageenan-induced edema of the hind paw of rats, acetic acid-induced writhing response in mice. The perimeter of the paw was measured before injection and then at 1, 2, 4, 6 h after injection of 1% $\lambda$-carrageenan. The HT008 at five dose levels (10, 30, 100, and 300 mg/kg) and distilled water given 30 min to treatment groups and control group, before $\lambda$-carrageenan injection. In the writhing test, the mice received 0.7% acetic acid solution in normal saline injected intraperitoneally at a dose of 10 ml/kg. The number of writhes was counted staring 10 min after injection. Results : HT008 at four dose levels (30, 100, and 300 mg/kg) significantly decreased the carrageenan-induced rat paw edema perimeter. E. senticosus and S. baicaleinsis extracts reduced acetic acid-induced writhing response in mice. Also A. sinensis extracts significantly decreased the carrageenan-induced rat paw edema perimeter. Conclusions : These results show that HT008, a multi-herbal mixture has both anti-inflammatory activity and analgesic effects in vivo arthritic model, and suggest that HT008 could be a good therapy to treat human osteoarthritis.

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