Molecular & Cellular Toxicology

  • 제5권1호
  • /
  • Pages.93-98
  • /
  • 2009
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  • 1738-642X(pISSN)
  • /
  • 2092-8467(eISSN)
대한독성유전 단백체학회 (The Korean Society of Toxicogenomics and Toxicoproteomics)
권호 표지

Biological Safety and B Cells Activation Effects of Stephania delavayi Diels

  • Park, Dae-Hun (Korea Institute of Oriental Medicine) ;
  • Li, Yong-Chun (Korea Institute of Oriental Medicine) ;
  • Shim, Jae-Gal (Cancer Experimental Resources Branch, National Cancer Center) ;
  • Xu, Hong-De (School of Veterinary Medicine, Kangwon National University) ;
  • Li, Lan (School of Veterinary Medicine, Kangwon National University) ;
  • Lee, Min-Jae (School of Veterinary Medicine, Kangwon National University) ;
  • Kwon, Myung-Sang (School of Veterinary Medicine, Kangwon National University)
  • 발행 : 2009.03.31
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초록

Stephania delavayi Diels. has been used as an immune activator or an anti-inflammatory drug in China. We examined the immune modulation effect and 7-days repeated-dose toxicity to validate its biological safety and efficiency. Mice were repeatedly administrated with 50 mg/kg S. delavayi Diels. daily by I.P for 7 days. S. delavayi Diels. induced B cell activation but had no effect on other immune cells such as T cell, natural killer (NK) cell, and macrophage ($M{\varphi}$). S. delavayi Diels.-treated group exhibited no statistical significance from the control group in physical conditions; body weight, complete blood count (CBC), serum biochemical indexes etc. There was no difference between the control group and S. delavayi Diels.-treated group in gross findings such as histopathological alteration. In conclusion, S. delavayi Diels. is safe above the dose of immune modulation.

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