Molecular & Cellular Toxicology

The Korean Society of Toxicogenomics and Toxicoproteomics (대한독성유전 단백체학회)
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Chlorella vulgaris May Excrete Dioxin-like PCB-138, -153 via Urine of Rats

  • Om, Ae-Son (Department of Food and Nutrition, College of Human Ecology, Hanyang University) ;
  • Shin, Hye-Seoung (Hankyung National University, Analysis Center) ;
  • Shim, Jae-Young (Department of Food and Nutrition, College of Human Ecology, Hanyang University) ;
  • Han, Jae-Gab (DAESANG Corp. Health R & D Center) ;
  • Kim, Jae-Hyoun (Health Science, School of Natural Science, Dongduk Women's University)
  • Published : 2009.03.31
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Abstract

The effect of Chlorella vulgaris (CV) on the urinary excretion of di-ortho PCB congeners (PCB-138, -153) was investigated. Sprague-Dawley rats (6-weeks-old, n=10 rats/group) were randomly divided into one control (0CV) or 2% CV (2CV) or 5% CV (5CV) or 10% CV (10CV) groups, respectively. Composition of normal and chlorella meal-based diet were made up of 30% casein, 15% cornstarch, 50% sucrose, 5% cellulose, 5% coconut oil, 3.5% mineral mixture, 1 % vitamin mixture. All rats had free access to water and diet for 4 weeks. A significant increase in both PCB 138 and 153 in urinary level was detected in CV fed groups, 540% and 167% for 2CV, 155% and 89% for 5CV, 114% and 144% for 10CV group, respectively, when compared with their controls. These findings suggest that CV may have potential to eliminate body burden levels of dioxin-like PCB compounds.

Keywords

References

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