Fisheries and Aquatic Sciences

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Inhibitory Effects of Seaweed Extracts on Growth of Malassezia furfur and Malassezia restricta

  • Choi, Jae-Suk (RIS Center, Industry-Academic Cooperation Foundation, Silla University) ;
  • Lee, Bo-Bae (RIS Center, Industry-Academic Cooperation Foundation, Silla University) ;
  • Joo, Chi-Un (RIS Center, Industry-Academic Cooperation Foundation, Silla University) ;
  • Shin, Su-Hwa (RIS Center, Industry-Academic Cooperation Foundation, Silla University) ;
  • Ha, Yu-Mi (RIS Center, Industry-Academic Cooperation Foundation, Silla University) ;
  • Bae, Hee-Jung (RIS Center, Industry-Academic Cooperation Foundation, Silla University) ;
  • Choi, In-Soon (Department of Biological Science, Silla University)
  • Published : 2009.03.31
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Abstract

Fifty seven species of common seaweed from the coast of Korea were screened for antifungal activity against Malassezia species. Seaweeds as a source of bioactive compounds are able to produce a great variety of secondary metabolites with different activities. There are numerous reports on the biological activities of seaweeds against human pathogens, fungi, and yeasts, but only few contain data regarding inhibitory effects against Malassezia sp., a major cause of dandruff and seborrheic dermatitis. To help address this paucity of information, this work was carried out to examine the antifungal effects of seaweed extracts against M. furfur and M. restricta. Of the fifty seven species of marine algae screened for their potential antifungal activity, only 17 species (29.8%) exhibited inhibitory activity. In agar disc diffusion method, the ether extracts of Corallina pilulifera, Enteromorpha linza, Laminaria japonica, Symphyocladia latiuscula and Ulva sp. showed strong antifungal activity. To identify major constituents in seaweed extracts, four selected extracts were analyzed on' a GC-MS equipped with a flame ionization detector, and compared to spectral data from databases WILEY229.LIB and NIST107.LIB. Most constituents in seaweed extracts are fatty acid-related compounds. When we evaluated any acute toxicity, the ether extracts of the selected four species were not toxic in mice. According to these results, it can be suggested that these seaweed extracts are valuable for the development of therapeutic agents in treating dandruff and seborrheic dermatitis. Further investigations to determine its bioactive compound(s) are currently in progress.

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References

  1. Ara, J., V. Sultana, R. Qasim, S. Ehteshamul-Haque and V. U. Ahmad. 2005. Biological activity of Spαtoglossum asperum: a brown alga. Phytother. Res., 19, 618-623 https://doi.org/10.1002/ptr.1699
  2. Calza, P., M. Cristina, P. Ezio and M. Claudio. 2008. Solar driven production of toxic halogenated and nitroaromatic compounds in natural seawater. Sci. TotalEnviron., 398, 196-202 https://doi.org/10.1016/j.scitotenv.2008.03.023
  3. Cetkovska, P. and K. Pizinger. 2006. Coexisting subacute and systemic lupus erythematosus after terbinafine administration: successful treatment with mycophenolate mofetil. lnt. J. Dermatol., 45, 320-322 https://doi.org/10.1111/j.1365-4632.2004.02472.x
  4. Cho, J.y., J.Y. Kang, M.N.A. Khan, N.H. Park, S.K. Kim and y.K. Hong. 2007. Anti-inflammatory activities of Undaria pinnatifidα and Laminaria jαrponica (Phaeophyta). J. Fish. Sci. Technol., 10, 127-132
  5. Crespo, M., M. Abarca and F. Cabanes. 2000. Evaluation of different preservation and storage methods for malassezia spp. J. Clin. Microbiol., 38, 3872-3875
  6. Del Val, A.G., G. Platas, A. Basilio, A. Cabello, J. Gorrochatεgui， J. Suay, F. Vicente, E. Portillo, M.J. del Rio, G.G. Reina and F. Pelaez. 2001. Screening of antimicrobial activities in red, green and brown macroalgae from Gran Canaria (Canary Islands, Spain). Int. Microbiol., 4(1), 35-40
  7. Gemmer, C.M., Y.M. De Angelis, B. Theelen, T. Boekhout and T.L. Dawson. 2002. Fast, noninvasive method for molecular diction and differentiation of Malassezia yeast species on human skin and application of the method to dandruff microbiology. J. Clin. Microbiol., 40, 3350-3357 https://doi.org/10.1128/JCM.40.9.3350-3357.2002
  8. Gupta, A.K., Y. Kohli, A. Li, J. Faergemann and R.C. Summerbell. 2000. In vitro susceptibility of the seven Malassezia species to ketoconazole, voriconazole,itraconazole and terbinafine. Br. J. Dermatol., 142, 758-765 https://doi.org/10.1046/j.1365-2133.2000.03294.x
  9. Hetu, C., A. Dumont and J.G. Joly. 1983. Effect of chronic ethanol administration on bromobenzene liver toxicity in the rat. Toxicol. Appl. Pharmacol., 67, 166-177 https://doi.org/10.1016/0041-008X(83)90221-1
  10. Jo, J.H., H.S. Jang, H.C. Ko, M.B. Kim, C.K. Oh, Y.w. Kwon and K.S. Kwon. 2005. Pustular psoriasis and the Kobner phenomenon caused by allergic contactdermatitis from zinc pyrithione-containing shampoo. Contact Dermat., 52, 142-144 https://doi.org/10.1111/j.0105-1873.2005.00528.x
  11. Khaleafa, K.F., M.A.M. Kharboush, A. Metwalli, A.F. Mohsen and A. Serwi. 1975. Antibiotic (fungicidal) action from extracts of some seaweeds. Bot. Mar., 18, 163-165 https://doi.org/10.1515/botm.1975.18.3.163
  12. Leeming， J.P., J.E. Sansom and J.L. Burton. 1997. Susceptibility of Malassezia furfur subgroups to terbinafine. British J. Dermatol., 137, 764-767 https://doi.org/10.1111/j.1365-2133.1997.tb01115.x
  13. Mayer, A.M.S. and M.T. Hamann. 2002. Marine pharmacology in 1999: compounds with antibacterial, anticoagulant, antifungal, anthelmintic, anti -inflammatory, antiplatelet，antiprotozoal and antiviral activities affecting the cardiovascular, endocrine, immune and nervous systems, and other miscellaneous mechanisms of action. Comp. Biochεm. Physiol., 132, 315-339 https://doi.org/10.1016/S1532-0456(02)00094-7
  14. Moreau, J., D. Pesando and B. Caram. 1984. Antifungal and antibacterial screening of Dictyotales from the French Mediterranean cost. Hydrobiologia, 116/117, 521-524
  15. Newman, D.J., G.M. Cragg and K.M. Snader. 2003. N atural products as sourcεs of new drugs over the period 1981-2002. J. Nat. Prod., 66, 1022-1037 https://doi.org/10.1021/np030096l
  16. Nielsen, N.H. and T. Menne. 1997. Allergic contact dermatitis caused by zine pyrithione associated with pustular psoriasis. Am. J. Contact Dermat.， 8, 170-171 https://doi.org/10.1016/S1046-199X(97)90100-7
  17. Oh, Y. S., I.K. Lee and S.M. Boo. 1990. An annotated account of Korean economic seaweeds for food, medical and industrial uses. Korean J. Phycol., 5, 57-71
  18. Okazaki, A. 1971. Seaweeds and their uses in Japan. Tokai Univ. Press, 165
  19. Padmakumar, K. and K. Ayyakkannu. 1997. Seasonal variation of antibacterial and antifungal activities of the extracts of marine algae from southem coasts ofIndia. Bot. Mar., 40, 507-515 https://doi.org/10.1515/botm.1997.40.1-6.507
  20. Pesando, D. 1990. Antibacterial and antifungal activities of marine algae. In : Introduction to Applied Phycology, Akatsuka l. ed. SPB Academic Publishing, The hague, 9-26
  21. Pfaller, M.A. and D.J. Diekema. 2004. Rare and emerging opportunistic fungal pathogens: concem for resistance beyond Candida albicans and Aspergillus fumigates. J. Clin. Microbiol., 42, 4419-4431 https://doi.org/10.1128/JCM.42.10.4419-4431
  22. Pierard, G.E., J.E. Arrese，C. Pierard-Franchimont and P. de Doncker. 1997. Prolonged effects of antidandruff shampoos-time to recurrence of Mαlassezia ovalis colonization of skin. Int. J. Cosmet. Sci., 19, 111-117 https://doi.org/10.1111/j.1467-2494.1997.tb00174.x
  23. Pierard-Franchimont, C., J.E. Hermanns, H. Degreef and G.E. Pierard. 2000. From axioms to new insights into dandruff. Dermatology, 200, 93-98 https://doi.org/10.1159/000018337
  24. Rao, P.P.S., P.S. Rao and S.M. Karmarkar. 1986. Antifungal activity of crude extracts of different species of Indian Sargassum (Phaeophyceae). Seaweed Res. Utiln., 9, 25-29
  25. Tariq, Y.N. 1991. Antifungal activity in crude extracts of marine red algae. Mycol. Res., 95, 1433-1440 https://doi.org/10.1016/S0953-7562(09)80398-5
  26. Sugita, T., M. Tajima, T. Ito, M. Saito, R. Tsuboi and A. Nishikawa. 2005. Antifungal activities of tacrolimus and azole agents against the eleven current1y accepted Malassezia species. J. Clin. Microbiol., 43 , 2824-2829 https://doi.org/10.1128/JCM.43.6.2824-2829.2005
  27. Wang, W., Y. Okada, H. Shi, Y. Wang and T. Okuyama. 2005. Structures and aldose reductase inhibitory effects of bromophenols from the red alga Symphyocladia latiuscula. J. Nat. Prod., 68, 620-622 https://doi.org/10.1021/np040199j
  28. White, T., K. Marr and R. Bowden. 1998. Clinical, cellular and molecular factors that contribute to antifungal drug resistance. Clinical Microbiology Reviews, 11, 382-402
  29. WHO. 1992. Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicine. Regional Office for Westem Pacific, Manila, Philippines, 1-38

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