The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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The Inhibitory Effects of Portulaca oleracea L. on HCl-ethanol Induced Gastritis in Rats

염산-에탄올에 의해 유발된 흰쥐 위염에 대한 마치현의 억제 작용

  • Kim, Chae-Hyun (Dept. of Prescriptionology, College of Oriental Medicine, Dongshin University)
  • 김재현 (동신대학교 한의과대학 방제학교실)
  • Published : 2009.03.30
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Abstract

Objectives : The objective of this study was to examine the effects of P. oleracea into the HCl-ethanol induced gastritis in rats, and to isolate and determine the chemical compounds from P. oleracea. Methods : The rats were orally administered with crude extract or fractions or isolated compounds of P. oleracea 30 mins before the induction of gastric lesion by oral administration of HCl-ethanol. The gastric lesional area was measured using pixel counting software. Then the chemical compounds from P. oleracea was isolated and determined by LC-MS and NMR. Results : The inhibition effect of oral administration of crude extract of P. oleracea at a dose of 500 mg/kg in HCl-ethanol induced gastritis was similar to cimetidine. Then, aqueous fraction at a dose of 240 mg/kg exhibited the effects similar to cimetidine. Then, the aqueous fraction was further separated by MPLC and yielded four sub fractions. Among those sub fractions, agent II at a dose of 40 mg/kg possessed the strongest effect in the HCl-ethanol induced gastritis. The water fraction yielded-Uridine, Adenosine, Guanosine, which were characterized by Mass, 1H-NMR, 13C-NMR. Conclusions : This study suggest that a P. oleracea and its compounds showed potent efficacy on the development of HCl-ethanol induced gastritis. Thus, P. olaracea can be a potential natural resource for the management of gastritis although the mechanism of action involved in the treatment remains to be explored.

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References

  1. Li X, Wang H. Chinese herbal medicine in the treatment of chronic kidney disease. Adv Chronic Kidney Dis. 2005 ; 12 : 276-81. https://doi.org/10.1016/j.ackd.2005.03.007
  2. Isin Y, Ismail T, Askim HS, Tijien D. Salinity tolerance of purslane (Portulaca oleracea L.) is achieved by enhanced antioxidative system, lower level of lipid peroxidation and proline accumulation. Environmental and Experimental Botany. 2007 ; 61 : 49-57. https://doi.org/10.1016/j.envexpbot.2007.02.010
  3. Lim YY, Quah. Antioxidant properties of different cultivars of Portulaca oleracea. Food chemistry. 2007 ; 3 : 734-40.
  4. Sin MK. Clinical Traditional Herbalogy. Seoul : Younglimsa. 2002 : 417-8.
  5. Zheng HZ, Hong DZ, She J. Modern study of Traditional Chinese Medicine. Beijing Xue Yuan Press. 1997 : 753-61.
  6. Teng JL, Cui H. Chinese Materia Medica. Beijing : People's Medical Publishing House. 2007 : 65.
  7. Ahn DK. Illustrated Book of Korean Medicinal Plant. Kyo-hak publishing Co. 2003 : 66.
  8. Zhang XJ, Ji YB, Qu ZY, Xia JC, Wang L. Experimental studies on antibiotic functions of Portulaca oleracea L. in vitro. Chinese J Microecol. 2002 ; 14 : 277-80.
  9. Sakai N, Inada K, Okamoto M, Shizuri Y, Fukuyama Y. Portuloside A, a monoterpene glucoside from Portulaca oleracea. Phytochemistry. 1996 ; 42 : 1625-8. https://doi.org/10.1016/0031-9422(96)00202-6
  10. Chan K, Islam MW, Kamil M, Radhakrishnan R, Zakaria MNM, Habibullah M, Attas A. The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. sativa (Haw.) Celak. J Ethnopharmacol. 2000 ; 73 : 445-51. https://doi.org/10.1016/S0378-8741(00)00318-4
  11. Parry O, Marks JA, Okwuasaba F. The skeletal muscle relaxant action of Portulaca oleracea: role of potassium ions. J Ethnopharmacol. 1993 ; 40 : 187-94. https://doi.org/10.1016/0378-8741(93)90067-F
  12. Habtemariam S, Harvey AL, Waterman PG. The muscle relaxant properties of Portulaca oleracea are associated with high concentrations of potassium ions. Journal of Ethnopharmacology. 1993 ; 40 : 195-200. https://doi.org/10.1016/0378-8741(93)90068-G
  13. Parry O, Okwuasaba FK, Ejike C. Skeletal muscle relaxant action of an aqueous extract of Portulaca oleracea in the rat. Journal of Ethnopharmacology. 1987 ; 19 : 247-53. https://doi.org/10.1016/0378-8741(87)90002-X
  14. Rashed AN, Afifi FU, Disi AM. Simple evaluation of the wound healing activity of acrude extract of Portulaca oleracea L. (growing in Jordan) in Mus musculus JVI-1. J Ethnopharmacol. 2003 ; 88 : 131-6. https://doi.org/10.1016/S0378-8741(03)00194-6
  15. Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic–phosphotungstic acid reagents. American Journal of Enology and Viticulture. 1965 ; 16 : 144–58.
  16. Ernst P. Review article: the role of inflammation in the pathogenesis of gastric cancer. Aliment Pharmacol. 1999 : 13-8.
  17. Vinay Kumar, Abul K Abbas, Nelson Fausto, Richard N. Mitchell : Robbins basic pathlogy. 8th edition. Elsevier. 2007 : 593.
  18. Emanuel Rubin, John L. Farber : Pathology. second edition. Lippincott. 1995 : 632.
  19. Karimi G, Hosseinzadeh H, Ettehad N. Evaluation of the gastric antiulcerogenic effects of Portulaca oleracea L. extracts in Mice. Phytother Res. 2004 ; 18 : 484-7. https://doi.org/10.1002/ptr.1463
  20. Islam MW, Liu XM, Radhakrishnan R, Al-Gifri AN, Abdullah. E, Chen HB, Al-Naji MA. Effect of Araak (Salvadora persica Linn.); Purslane (Portulaca oleracea) and Their Combination on Gastric Ulcers and Secretions in Rats. Kingdom of Bahrain : The Arab Conference on Medicinal Plants, Manama. 2002 : 291-95.
  21. Mizui T, Sato H, Hirose F, Doteeuchi M. Effect of antiperoxida-tive drugs on gastric damage induced by ethanol in rat. Life Sci. 1987 ; 41 : 755-63. https://doi.org/10.1016/0024-3205(87)90456-5