Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Anti-hyperlipidemic Effects of the Flavonoid-rich Fraction from the Methanol Extract of Orostachy japonicus in Rats

식이성 고지혈증 흰쥐에 대한 와송 플라보노이드 분획물의 효과

  • Kim, Sei-Gun (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University) ;
  • Choi, Jong-Won (College of Pharmacy, Kyungsung University) ;
  • Park, Hee-Juhn (Department of Pharmaceutical Engineering, Sangji University) ;
  • Lee, Sang-Myung (KT&G Central Research Institute) ;
  • Jung, Hyun-Ju (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
  • 김세건 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 최종원 (경성대학교 약학대학) ;
  • 박희준 (상지대학교 제약공학과) ;
  • 이상명 (KT&G 중앙연구원) ;
  • 정현주 (원광대학교 약학대학 한약학과 및 원광한약연구소)
  • Published : 2009.03.31
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Abstract

The anti-hyperlipidemic effects of an ethyl acetate fraction from Orostachy japonicus in a high lipid diet-induced hyperlipidemic rat model were assessed. The fraction, which contained kaempferol, astragalin, and isoquercitrin, was associated with significant weight loss and reduction of lipid contents in serum and liver tissues. The fraction, which contains mainly flavonoids, diminished the levels of malondialdehyde and hydroxyl radical, and increased the anti-oxidative enzyme activities of superoxide dismutase, catalase, and glutathione peroxidase. Reduced bleeding and plasma clotting times resulting from the administration of the ethyl acetate fraction may reduce cardiovascular disease associated with hyperlipidemia.

Keywords

References

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