Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
권호 표지

Antimicrobial Activities of the Anti-acne Compounds from Natural Sources

천연물유래 여드름 치료제제의 항균활성 측정

  • Kim, Na-Rae (Department of Clinical Laboratory Science, College of Health Science, Korea University) ;
  • Lim, Young-Hee (Department of Clinical Laboratory Science, College of Health Science, Korea University) ;
  • Park, Sul-Woong (SD Biotechnologies Co., Ltd.) ;
  • Nam, Eun-Sil (SD Biotechnologies Co., Ltd.)
  • 김나래 (고려대학교 보건과학대학 임상병리학과) ;
  • 임영희 (고려대학교 보건과학대학 임상병리학과) ;
  • 박설웅 ((주)에스디생명공학) ;
  • 남은실 ((주)에스디생명공학)
  • Published : 2009.03.28
Download PDF
⟨ Previous Next ⟩

Abstract

The in vitro antibacterial activities of anti-acne agents prepared from the extracts of natural sources were investigated against several bacteria including antibiotic-susceptible and -resistant Propionibacterium acnes. SD-1 and SD-2 were prepared with different formulations and they showed strong antibacterial activities. The anti-acne agents completely inhibited the growth of the tested strains at the concentration of 0.5%. There was no difference in antibacterial activity between antibiotic-susceptible and -resistant P. acnes. The inhibitory activities of two agents showed time-dependent manner. In S. aureus, time-kill curve demonstrated 2.8- and 3.4-$log_{10}$-unit killing after 8 h with SD-1 and SD-2, respectively. In P. acnes, time-killing curve demonstrated 5.1- and 6.1-$log_{10}$-unit killing after 24 h with SD-1 and SD-2, respectively. SD-2 showed stronger antimicrobial activity than SD-1. From these results, we expect that SD-1 and SD-2 have strong antibacterial activities and have advantages for treating acne.

Keywords

References

  1. Baker, D. D., M. Chu, U. Oza, and V. Rajgarhia. 2007. The value pf natural products to future pharmaceutical discovery. Nat. frod. Rep. 24: 1225-1244 https://doi.org/10.1039/b602241n
  2. Burton, J. L. and S. Shuster. 1971. The relationship between seborrhea and acne vulgaris. Br. J. Dennatol. 84: 600-604
  3. Cunliffe, W. J., D. B. Holland, and A. Jeremy. 2004. Comedone formation: etiology, clinica1 presentation, and treatment. Clin. Dennatol. 22: 367-374 https://doi.org/10.1016/j.clindermatol.2004.03.011
  4. Lam, K. S. 2007. New aspects of natural products in drug discovery. Trends Microbiol. 15: 279-289 https://doi.org/10.1016/j.tim.2007.04.001
  5. Lim, Y. S., K. B. Myung, N. E. Chung, and W. S. Chung. 1995. A study on the MIC of antibiotics for Propionibactcrium acnes in patientli with acne. Kor. J. Dennatol. 33: 437-444
  6. National Committee for Clinical Laboratory Standards. 2001. Perforrnance Standards for Antirnicrobia1 Disk Susceptibility Tests, 7th ed. Approved Standard MA7. National Committee for Clinical Laboratory Standards. Wayne. Pa
  7. Newman, D. J., G. M. Cragg, and K. M. Snader. 2003. Natural products as sources of new drugs over the period 1891-2002. J. Nat. Prod. 66: 1022-1037 https://doi.org/10.1021/np030096l
  8. Osato, J. A., L. A. Santiago, G. M. Remo, M. S. Cuadra, and A. Mori. 1993. Antirnicrobiíll and antioxidant activities of unripe papaya. Life Sci. 53: 1383-1389 https://doi.org/10.1016/0024-3205(93)90599-X
  9. Rhoades, J. and S. Roller. 2000. Antirnicrobial actions of degraded and native chitosan against spoilage organisms in laboratory media and foods. Appl. Environ. Microbiol. 66: 80-86 https://doi.org/10.1128/AEM.66.1.80-86.2000
  10. Rauha, J. P., S. Remes, M. Heinonen, A. Hopia, M. Khknen, T. Kuja1a, K. Pihlaja, H. Vuorela, and P. Vuorela. 2000. Antirnicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds. Intl. J. Food Microbiol. 56: 3-12 https://doi.org/10.1016/S0168-1605(00)00218-X
  11. Webster, G. F. and E. M. Graber. 2008. Antibiotic treatment for acne vulgaris. Semin. Cutan. Med. Surg. 27: 183-187 https://doi.org/10.1016/j.sder.2008.07.001