Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Antidiabetic Synergetic Effects of Plant Extract-Mixtures in Streptozotocin-Diabetes Rats

STZ으로 유발된 당뇨쥐에 대한 식물추출 혼합물의 항당뇨 상승효과

  • Roh, Sang-Geun (Department of Biology, College of Natural Sciences, Pusan National University) ;
  • Kim, Jong-Hae (Division of Electronic Engineering, Sun Moon University) ;
  • Choi, Won-Chul (Department of Biology, College of Natural Sciences, Pusan National University)
  • Published : 2009.03.31
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Abstract

This study investigates the effects of Psidium guajava L. leaf (Pg), Lagerstroemia speciosa L. leaf (Ls) and mixture A (Pg, Ls, Morus indica L. leaf extract, Pinus densiflora needles extract, Acanthopanax senticosus M. root extract) on streptozotocin (STZ)-diabetes rats. For four weeks, STZ-diabetes rats were fed crystallized extracts of Pg, Ls, and mixture A. Compared to the diabetic control group, extracts of Pg, Ls, and mixture A decreased glucose levels in rats by 20%, 14% and 24% respectively. These extracts also decreased the level of total cholesterol, triglyceride and free fatty acid, compared to the diabetic control group, while effectively increasing levels of insulin and high-density lipoprotein-cholesterol. These results showed that mixture A had greater antihyperglycemic, antihyperlipidemic, and insulin-increasing effects than the Pg and Ls extracts. Mixture A also showed better restoration of damaged beta cell function compared to Pg and Ls extracts. Therefore, it was proved that mixture A provides a beneficial synergistic effect when compared with Pg and Ls extracts used individually.

본 연구는 streptozotocin (STZ)으로 당뇨를 유발한 실험쥐에 대한 Psidium guajava L. 잎(Pg), Lagerstroemia speciosa L. 잎(Ls) 추출물 그리고 혼합물 A (Pg, Ls, Morus indica L. 잎 추출물, Pinus densiflora needles 추출물, Acanthopanax senticosus M. roots 추출물)의 효과를 조사하였다. 4주간 streptozotocin (STZ)으로 당뇨를 유발한 실험쥐에 이들 추출물을 섭취시킨 결과 Pg, Ls 그리고 혼합물 A의 섭취는 당뇨 대조군에 비해 혈당을 각각 20%, 14% 그리고 24% 감소시켰다. 또한 이들 추출물의 섭취는 총 콜레스트롤, 중성지방, 유리지방산을 감소시켰고 인슐린과 HDL-콜레스트롤을 효과적으로 증가시켰다. 결론적으로 혼합물 A는 Pg와 Ls 추출물에 비해 혈당 및 지질 감소, 인슐린 증가 효과 그리고 기능적으로 손상된 베타세포의 회복이 더 높은 것으로 나타났다. 따라서 혼합물 A는 개별적으로 사용한 Pg와 Ls 추출물에 비해 더욱 유익한 상승효과를 발휘하는 것으로 증명되었다.

Keywords

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