DOI QR코드

DOI QR Code

Micro-tissue collecting tool for diagnosis of micro-spike biopsy

마이크로 스파이크로 채취한 조직의 진단을 위한 미세 조직회수도구

  • Jeong, Hyo-Young (ASRI/ISRC/NB & SRC, Seoul National University) ;
  • Koo, Kyo-In (ASRI/ISRC/NB & SRC, Seoul National University) ;
  • Lee, Sang-Min (ASRI/ISRC/NB & SRC, Seoul National University) ;
  • Ban, Jae-Won (ASRI/ISRC/NB & SRC, Seoul National University) ;
  • Park, Ho-Soo (ASRI/ISRC/NB & SRC, Seoul National University) ;
  • Bang, Seoung-Min (Department of Internal Medicine, College of Medicine, Yonsei University) ;
  • Song, Si-Young (Department of Internal Medicine, College of Medicine, Yonsei University) ;
  • Cho, Dong-Il Dan (ASRI/ISRC/NB & SRC, Seoul National University)
  • 정효영 (서울대학교 자동화시스템공동연구소/반도체공동연구소/초미세생체전자 시스템연구센터) ;
  • 구교인 (서울대학교 자동화시스템공동연구소/반도체공동연구소/초미세생체전자 시스템연구센터) ;
  • 이상민 (서울대학교 자동화시스템공동연구소/반도체공동연구소/초미세생체전자 시스템연구센터) ;
  • 반재원 (서울대학교 자동화시스템공동연구소/반도체공동연구소/초미세생체전자 시스템연구센터) ;
  • 박호수 (서울대학교 자동화시스템공동연구소/반도체공동연구소/초미세생체전자 시스템연구센터) ;
  • 방승민 (연세대학교 의과대학 소화기내과) ;
  • 송시영 (연세대학교 의과대학 소화기내과) ;
  • 조동일 (서울대학교 자동화시스템공동연구소/반도체공동연구소/초미세생체전자 시스템연구센터)
  • Published : 2009.03.31

Abstract

We have developed and reported several micro-spikes for minimally invasive biopsy. In this paper, a micro-tissue collecting tool for tissue diagnosis extracted by micro-spike is presented. Using proposed polydimethy-siloxane (PDMS) micro-tissue collecting tool, which has a negative micro-spike structure in a porous chamber, the extracted tissue in a micro-spike is effectively detached. The gastro-intestinal tissue of a pig is extracted in an in vivo environment, and then it is detached from a micro-spike using the PDMS micro-tissue collecting tool. A fine clinical picture of the detached tissue is acquired.

Keywords

References

  1. Donald C. Zavola, 'Diagnostic fiberoptic bronchoscopy: Techniques and results of biopsy in 600 patients', Chest, vol. 68, no. 1, pp. 12-19, 1975 https://doi.org/10.1378/chest.68.1.12
  2. K. L. Woods, B. S. Anand, R. A. Cole, M. S. Osato, Robert, M. Genta, H. Malaty, I. E. Gurer, and D. De Rossi, 'Influence of endoscopic biopsy forceps characteristics on tissue specimens : results of a prospective randomized study', Gastrointestinal endoscopy, vol. 49, no. 2, pp. 177-183, 1999. https://doi.org/10.1016/S0016-5107(99)70483-9
  3. DD. Wadas, and RA. Sanowski, 'Complications of the hot biopsy forceps technique', Gastrointestinal endoscopy, vol. 34, no. 1, pp. 32-39, 1988 https://doi.org/10.1016/S0016-5107(88)71226-2
  4. 이아라, 백승준, 구교인, 박선길, 최병두, 정명준, 최현 민, 임정민, 서종모, 김경아, 정흠, 전도영, 이승섭, 조 동일, 'A novel microbiopsy tool for microsurgery', 한 국센서학회 종합학술대회, pp. 154-155, 제주, 대한민 국, 2004
  5. S. Byun, J. M. Lim, S. J. Paik, A. Lee, K. Koo, S. Park, J. Park, B. D. Choi, J. M. Seo, K. Kim, H. Chung, S. Y. Song, D. Jeon, and D. “Dan” Cho, 'Barbed micro-spikes for micro-scale biopsy,' J. Micromech. Microeng., vol. 15, no. 6, pp. 1279-1284, 2005 https://doi.org/10.1088/0960-1317/15/6/020
  6. A. R. Lee, S. J. Paik, S. G. Park, M. J. Jeong, K. I. Koo, H. M. Choi, J. M. Seo, K. A. Kim, H. , Chung, S. Y. Song, S. M. Bang, D. Y. Jeon, J. M. Lim, and D. I. Cho, '3D silicon-micromachined microbiopsy tool and In-vivo experiment', The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, vol. 2, pp. 1199-1202, Seoul, Korea, 2005
  7. S. K. Park, A. R, Lee, M. J. Jeong, H. M. Choi, S. Y. Song, S. M. Bang, S. J. Paik, J. M. Lim, D. Y. Jeon, S. K. Lee, C. N. Chu, and D. I. Cho, 'A disposable MEMS-based micro-biopsy catheter for the minimally invasive tissue sampling', IEEE/RSJ International Conference on Intelligent Robots an Systems, Edmonton, Canada, 2005
  8. G. S. Kim, S. K. Park, K. I. , Koo, H. M. Choi, M. J. Jung, S. Y. Song, S. M. Bang, and D. I. Cho, 'Nickel micro-spike for micro-scale biopsy using liga process', The 9th International Conference on Synchrotron Radiation Instrumentation, pp. 1449-1502, Daegu, Korea, 2006
  9. G. S. Kim, S. Park, K. Koo, M. Jeong, H. Choi, S. Paik, S. M. Bang, S. Y. Song, and D. 'Dan' Cho, 'Micro spike for endoscopic gastro biopsy,' Asia-Pacific Conference of Transducers and Micro-Nono Technology, Singapore, Singapore, 2006
  10. 백주열, 권구한, 이상훈, 'PDMS 기판상 금속층의 안정적 증착 및 패터닝,' 센서학회지, 제14권, 제6 호, pp. 423-429, 2005 https://doi.org/10.5369/JSST.2005.14.6.423
  11. J. Oberhammer and G. Stemme, 'Bcb contact printing for patterned adhesive full-wafer bonded 0-level packages', J. Microelectromech. Syst., vol. 14, no. 2, pp. 419-425, 2005 https://doi.org/10.1109/JMEMS.2004.839030