Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
권호 표지

EXPRESSION OF ESTROGEN RECEPTORS IN RETRODISCAL TISSUE OF THE TEMPOROMANDIBULAR JOINT DISORDER PATIENTS

측두하악관절 장애 환자에서 관절원판후조직의 에스트로겐 수용체(ER)의 단백 발현

  • Kim, Jong-Yun (Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, Yonsei University) ;
  • Lim, Jae-Hyung (Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, Yonsei University) ;
  • Park, Kwang-Ho (Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, Yonsei University) ;
  • Kim, Hyung-Gon (Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, Yonsei University) ;
  • Huh, Jong-Ki (Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, Yonsei University)
  • 김종윤 (연세대학교 강남세브란스병원 구강악안면외과) ;
  • 임재형 (연세대학교 강남세브란스병원 구강악안면외과) ;
  • 박광호 (연세대학교 강남세브란스병원 구강악안면외과) ;
  • 김형곤 (연세대학교 강남세브란스병원 구강악안면외과) ;
  • 허종기 (연세대학교 강남세브란스병원 구강악안면외과)
  • Published : 2009.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Those composing temporomandibular joint (TMJ) complex such as the temporal bone, the disc and the mandibular condyle perform their own functions with organic relation. The retrodiscal tissue is the main area of pain induction and contributes to compositional change of synovial fluid. If displacement of the disc lasts long time, not only adaptive changes, but also destructive or degenerative changes may happen. It was reported that these changes and symptoms appear mostly to female rather than male and especially, in the case of patients suffering from TMJ disorder, a large quantity of female sex hormone is found in the joint synovium. And that may play a role in bone resorption and inflammation. Also, the frequency and the intensity of pain perception for female is reported to be much more than for male. In this study, we investigated the expression extents of estrogen receptors (ER) and progesteron receptors (PR) in retrodiscal tissue with immunohistochemistry among the patients received TMJ surgery and compared with MRI findings and surgical findings. We report the relations between the expression of ER in retrodiscal tissue and the pathological change in TMJ, such as inflammation, internal derangement and osteoarthritis.

Keywords

References

  1. LeResche L. Epidermiology of temporomandibular disorders: Implications for the investigation of etiologic factors. Crit Rev Oral Biol Med 1997;8:291-305 https://doi.org/10.1177/10454411970080030401
  2. Kullila M, PM Niemi, S Kuttila, P Alanen, Y Le Bell. TMD treatment need in relation to age, gender, stress, and diagnostic subgroup. J Orofac Pain 1998;12:67-74
  3. Meisler JG. Chronic pain conditions in women. J Womens Health 1999;8:313-20 https://doi.org/10.1089/jwh.1999.8.313
  4. Landi N, Lombardi I, Manfredini D, Casarosa E, Biondi K, Gabbanini M, et al. Sexual hormone serum levels and temporomandibular disorders: A preliminary study. Gynecol Endocrinol 2005;20:99-103 https://doi.org/10.1080/09513590400021136
  5. Abubaker AO, Raslan WF, Sotereanos GC. Estrogen and progesterone receptors in temporomandibular joint discs of symptomatic and asymptomatic persons: A preliminary study. J Oral Maxillofac Surg 1993;51:1096-100 https://doi.org/10.1016/S0278-2391(10)80448-3
  6. Ko JY, Kim KD, Park CS. Magnetic resonance evidence of joint effusion in patients with temporomandibular joint disorders. Korean J Oral Maxillofac Radiol 2001;31:73-84
  7. Huh JK, Park KK, Choi MA, Kim HG. Expression of matrix metalloproteinase-1 and -2 mRNA in retrodiscal tissue of the temporomandibular joint. J Kor Oral Maxillofac Surg 2003;29:212-8
  8. Huh JK, Kim HG. Relationship between histologic features of the retrodiskal tissues and magnetic resonance imaging findings in temporomandibular joint internal derangement. J Kor Oral Maxillofac Surg 2000;25:378-82
  9. Dworkin SF, LeResche L. Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. J Craniomandib Disord 1992;6:301-55
  10. Stegenga B. Osteoarthritis of the temporomandibular joint organ and its relationship to disc displacement. J Orofac Pain 2001;15:193-205
  11. Stegenga B, de Bont LGM, Boering G. Osteoarthritis as the cause of craniomandibular pain and dysfunction: A unifying concept. J Oral Maxillofac Surg 1989;47:249-56 https://doi.org/10.1016/0278-2391(89)90227-9
  12. Stegenga B, de Bont LGM, Boering G, van Willigen JD. Tissue responses to degenerative changes in the temporomandibular joint. A review J Oral Maxillofac Surg 1991;49:1079-88 https://doi.org/10.1016/0278-2391(91)90143-A
  13. LeResche L, Saunders K, Von Korff MR, Barrlow W, Dworking SF. Use of exogenous hormones and risk of temporomandibular disorder pain. 1997;69:153-60 https://doi.org/10.1016/S0304-3959(96)03230-7
  14. Kapila S, Xie Y. Targeted induction of collagenase and stromelysin by relaxin in unprimed and beta-estradiol-primed diarthrodial joint fibrocartilaginous cells but not on synoviocytes. Lab Invest 1998;78:925-38
  15. Arnett GW, Milan SB, Gottesman L. Progressive mandibular retrusion-idiopathic condylar resorption. Part I Am J Orthod Dentofacial Orthop 1996;10:8-15 https://doi.org/10.1016/S0889-5406(96)70081-1
  16. McGuire WL, Horowitz KB, Pearson OH, Segaloff A. Current status of estrogen and progesterone receptors in breast cancer. Cancer 1977;32:2934-47 https://doi.org/10.1002/1097-0142(197706)39:6<2934::AID-CNCR2820390680>3.0.CO;2-P
  17. Kaplan PA, Helms CA. Current status of temporomandibular joint imaging for the diagnosis of internal derangements. AJR Am J Roentgenol 1989;152:697-705 https://doi.org/10.2214/ajr.152.4.697
  18. Stegenga B. Osteoarthritis of the temporomandibular joint organ and its relationship to disc displacement. J Orofac Pain 2001;15:193-205
  19. Isberg A, Isacsson G. Tissue reactions associated with internal derangement of the temporomandibular joint: A radiographic, crymorphologic, and histologic study. Acta Odontol Scand 1986;44:159-64 https://doi.org/10.3109/00016358609026568
  20. Corvol M, O Blanchard, L Tsagris. Bone and cartilage responsiveness to sex steroid hormones. J Steroid Biochem Mol Biol 1992;43:415-8 https://doi.org/10.1016/0960-0760(92)90078-W
  21. Gage JP. Collagen biosynthesis related to temporomandibular joint clicking in childhood. J Prosthet Dent 1985;53:714-7 https://doi.org/10.1016/0022-3913(85)90030-7
  22. Milam SB, Aufdemorte TB, Sheridan PJ, Triplett RG, Van Sickels JE, Holt GR. Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon. Oral Surg Oral Med Pathol 1987;64:527-32 https://doi.org/10.1016/0030-4220(87)90025-9
  23. Wilkinson TM, Crowley CM. A histologic study of retrodiscal tissues of the human temporomandibular joint in the open and closed position. J Orofac Pain 1994;8:7-17
  24. Nitzan DW, Mahler Y, Simkin A. Intra-articular pressure measurements in patients with suddenly developing, severely limited mouth opening. J Oral Maxillofac Surg 1992;50:1038-43 https://doi.org/10.1016/0278-2391(92)90485-I
  25. Romanelli GG, Harper R, Mock D, Pharoah MJ, Tenenbaum HC. Evaluation of temporomandibular joint internal derangement. J Orofac Pain 1993;7:254-62
  26. Kubota T, Kubota E, Matsumoto A, Kawai Y, Saito H, Mikuni-Takagaki Y, et al. Identification of matrix metalloproteinases (MMPs) in synovial fluid from patients with temporomandibular disorder. Eur J Oral Sci 1998;106:992-8 https://doi.org/10.1046/j.0909-8836.1998.eos106603.x
  27. Ratcliffe A, Israel HA, Saed-Nejad F, Diamond B. Proteoglycans in the synovial fluid of the temporomandibular joint as an indicator of changes in cartilage metabolism during primary and secondary osteoarthritis. J Oral Maxillofac Surg 1998;56:204-8 https://doi.org/10.1016/S0278-2391(98)90870-9
  28. Takahashi T, Nagai H, Seki H, Fukuda M. Relationship between joint effusion, joint pain, and protein levels in joint lavage fluid of patients with internal derangement and osteoarthritis of the temporomandibular joint. J Oral Maxillofac Surg 1999;57:1187-93 https://doi.org/10.1016/S0278-2391(99)90483-4
  29. Flake NM, Hermanstyne TO, Gold MS. Testosterone and estrogen have opposing actions on inflammation-induced plasma extravasation in the rat temporomandibular joint. Am J Physiol Regul Integr Comp Physiol 2006;291:343-8 https://doi.org/10.1152/ajpregu.00835.2005