Journal of Microbiology and Biotechnology

  • 제19권12호
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  • Pages.1573-1575
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  • 2009
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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Reticulone, a Novel Free Radical Scavenger Produced by Aspergillus sp.

  • Ryoo, In-Ja (Korea Research Institute of Bioscience and Biotechnology) ;
  • Xu, Guang-Hua (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Young-Hee (Korea Research Institute of Bioscience and Biotechnology) ;
  • Choo, Soo-Jin (Korea Research Institute of Bioscience and Biotechnology) ;
  • Ahn, Jong-Seog (Korea Research Institute of Bioscience and Biotechnology) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Yoo, Ick-Dong (Korea Research Institute of Bioscience and Biotechnology)
  • 발행 : 2009.12.31
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초록

Bioassay-guided fractionation of the culture broth of Aspergillus sp. FN070449 (KCTC 26428) using a DPPH (2,2-diphenyl-1-picrylhydrazyl) assay led to the isolation of two compounds: reticulone (1) and reticulol (2). Their chemical structures were elucidated on the basis of UV, IR, NMR, and MS spectroscopic analyses. Compound 1 exhibited more potent free radical scavenging activity on $ABTS^{\cdot+}$ (2,2'-azino-bis [3-ethylbenzthiazoline-6-sulphonic acid]) and DPPH radicals than did butylated hydroxyanisole (BHA) and caffeic acid.

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참고문헌

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피인용 문헌

  1. New Isocoumarin Derivatives and Meroterpenoids from the Marine Sponge-Associated Fungus Aspergillus similanensis sp. nov. KUFA 0013 vol.12, pp.10, 2009, https://doi.org/10.3390/md12105160