개의 육아종성 염증이 동반된 keratoacanthoma의 세포학적 고찰 증례

Cytologic Aspect of Keratoacanthoma with Granulomatous Inflammation in a Dog

  • 지향 (서울대학교 수의과대학 수의병리학) ;
  • 김대용 (서울대학교 수의과대학 수의병리학) ;
  • 지동범 (지동범 동물병원) ;
  • 최을수 (전북대학교 수의과대학 수의임상병리학과)
  • Ji, Hyang (Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Dae-Yong (Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Ji, Dong-Bum (Ji-Dong Bum Animal Hospital) ;
  • Choi, Ul-Soo (Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Chonbuk National University)
  • 발행 : 2009.12.31

초록

5세령의 페키니즈 견이 발생된 지 1년 된 등쪽 종괴의 평가를 위해 내원하였다. 종괴의 세침흡인 도말 표본의 세포학 검사에서 많은 수의 각화 상피세포와 거대 다핵 세포, 소수의 방추 세포가 관찰되었다. 세포학 검사결과 육아종성 표피낭 또는 모낭 종양이 의심되었고, 결절은 외과적으로 절제한 후 병리조직학적 검사를 실시하였다. 피하의 결절은 부분적으로 결합조직에 둘러싸여 있었으며, 주변조직과 경계가 명확하였다. 그 결절은 중심의 큰 낭과 주변의 작은 낭으로 이루어져 있었으며, 그 낭은 중심부에 층판상의 케라틴이 존재하였고 단층 또는 중층의 기저세포와 편평 상피세포로 둘러싸여 있었다. 다소성으로 다수의 대식구와 소수의 다핵거대세포가 관찰되었다. 이에 기초하여 육아종성 염증이 동반된 keratoacanthoma로 진단하였다. 종괴는 수술 제거 후 재발되지 않고 있다.

A 5-year-old Pekinese dog was presented for evaluation of a back mass of 1 year duration. Fine needle aspiration cytology of the mass revealed numerous keratinocytes, and a lesser number of multinucleated giant cells along with a low number of spindle cells, which were suggestive of epidermal cyst or hair follicle tumor with secondary granulomatous inflammation. The mass was surgically removed and examined histologically. Microscopically there was partially encapsulated well-demarcated nodule in deep dermis and subcutis. The nodule consisted of central cyst and secondary cysts that were lined by a single or multiple layers of basaloid cells and squamous epitheliums with central laminated keratin. Multifocal aggregation of numerous macrophages and multinucleated giant cells were present. The final diagnosis was keratoacanthoma with granulomatous inflammation. The mass did not recur 5 months after surgery.

키워드

참고문헌

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