Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Clinical Presentation and Management of Five Dogs with Apocrine Gland Adenocarcinoma of Anal Sac

다섯 마리의 개에서 발생한 아포크린샘암종 증례

  • Oh, Ye-In (College of Veterinary Medicine, Seoul National University) ;
  • Seo, Kyoung-Won (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Jun-Young (College of Veterinary Medicine, Seoul National University) ;
  • Youn, Jung-Hee (College of Veterinary Medicine, Seoul National University) ;
  • Hwang, Cheol-Young (College of Veterinary Medicine, Seoul National University) ;
  • Lee, Sang-Koo (Center for Laboratory Animal Science, College of Medicine, Hanyang University) ;
  • Youn, Hwa-Young (College of Veterinary Medicine, Seoul National University)
  • 오예인 (서울대학교 수의과대학) ;
  • 서경원 (서울대학교 수의과대학) ;
  • 김준영 (서울대학교 수의과대학) ;
  • 윤정희 (서울대학교 수의과대학) ;
  • 황철용 (서울대학교 수의과대학) ;
  • 이상구 (한양대학교 의과대학 실험동물센타) ;
  • 윤화영 (서울대학교 수의과대학)
  • Published : 2009.12.31
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Abstract

Five dogs diagnosed as apocrine gland adenocarcinoma (AGAC) of the anal sac based on cytology and/or histology. Mean age of these dogs was 11 years old. One dog treated with supportive care without other medical interventions for hypercalcemia was died one month after diagnosis. Other four dogs were treated with chemotherapy and one of these dogs was intervened with complete surgical resection. Two months after the diagnosis, one of the dogs treated with chemotherapy died. The survival time of other survived three dogs from the time of diagnosis was 19, 9, and 13 months respectively and they are still alive at this time. After chemotherapy, three dogs were managed generally in good body condition and maintained as similar in size as time of diagnosis. The results are suggested that it is worthwhile to try chemotherapy for managing AGAC in dogs especially complicated or metastasized to regional lymph nodes.

2006-2008년에 5마리의 환자가 아포크린샘암종으로 진단받았다. 품종은 다양하였으며 진단 당시 평균 연령은 11세이었다. 이들 중 3마리에서 종양으로 인한 고칼슘혈증이 발생하였으며, 한 마리는 화학요법(chemotherapy) 받지 않고 진단 1달 후 사망하였다. 나머지 네 마리의 환자들은 항암제 투여, 수술 등의 방법으로 치료를 받았으며 수술과 화학요법을 병행한 환자는 치료 종료 후 9개월째 완전완화(complete remission) 상태를 유지하고 있다. 화학요법만 받은 3마리의 환자들은 질병지속(stable disease) 상태로 유지되고 있으며 이 중 한 마리는 진단 후 2개월째에 사망하였다. 따라서 개의 아포크린샘암종의 치료법으로 수술 및 방사선 치료를 적용할 수 없는 경우에, 항종양제 단독 투여는 보조적으로 효과가 있는 것으로 사료된다.

Keywords

References

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