Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Clinical Presentation and Management of Five Dogs with Apocrine Gland Adenocarcinoma of Anal Sac

다섯 마리의 개에서 발생한 아포크린샘암종 증례

  • Oh, Ye-In (College of Veterinary Medicine, Seoul National University) ;
  • Seo, Kyoung-Won (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Jun-Young (College of Veterinary Medicine, Seoul National University) ;
  • Youn, Jung-Hee (College of Veterinary Medicine, Seoul National University) ;
  • Hwang, Cheol-Young (College of Veterinary Medicine, Seoul National University) ;
  • Lee, Sang-Koo (Center for Laboratory Animal Science, College of Medicine, Hanyang University) ;
  • Youn, Hwa-Young (College of Veterinary Medicine, Seoul National University)
  • 오예인 (서울대학교 수의과대학) ;
  • 서경원 (서울대학교 수의과대학) ;
  • 김준영 (서울대학교 수의과대학) ;
  • 윤정희 (서울대학교 수의과대학) ;
  • 황철용 (서울대학교 수의과대학) ;
  • 이상구 (한양대학교 의과대학 실험동물센타) ;
  • 윤화영 (서울대학교 수의과대학)
  • Published : 2009.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Five dogs diagnosed as apocrine gland adenocarcinoma (AGAC) of the anal sac based on cytology and/or histology. Mean age of these dogs was 11 years old. One dog treated with supportive care without other medical interventions for hypercalcemia was died one month after diagnosis. Other four dogs were treated with chemotherapy and one of these dogs was intervened with complete surgical resection. Two months after the diagnosis, one of the dogs treated with chemotherapy died. The survival time of other survived three dogs from the time of diagnosis was 19, 9, and 13 months respectively and they are still alive at this time. After chemotherapy, three dogs were managed generally in good body condition and maintained as similar in size as time of diagnosis. The results are suggested that it is worthwhile to try chemotherapy for managing AGAC in dogs especially complicated or metastasized to regional lymph nodes.

2006-2008년에 5마리의 환자가 아포크린샘암종으로 진단받았다. 품종은 다양하였으며 진단 당시 평균 연령은 11세이었다. 이들 중 3마리에서 종양으로 인한 고칼슘혈증이 발생하였으며, 한 마리는 화학요법(chemotherapy) 받지 않고 진단 1달 후 사망하였다. 나머지 네 마리의 환자들은 항암제 투여, 수술 등의 방법으로 치료를 받았으며 수술과 화학요법을 병행한 환자는 치료 종료 후 9개월째 완전완화(complete remission) 상태를 유지하고 있다. 화학요법만 받은 3마리의 환자들은 질병지속(stable disease) 상태로 유지되고 있으며 이 중 한 마리는 진단 후 2개월째에 사망하였다. 따라서 개의 아포크린샘암종의 치료법으로 수술 및 방사선 치료를 적용할 수 없는 경우에, 항종양제 단독 투여는 보조적으로 효과가 있는 것으로 사료된다.

Keywords

References

  1. Berrocal A, Vos JH, Ingh TSGAM van den, Molenbeek. RF, Sluijs FJ van. Canine perineal tumors. J Vet Med Ser A 1989; 36: 739-749 https://doi.org/10.1111/j.1439-0442.1989.tb00787.x
  2. Goldschmidt MH, Zoltowski C. Anal sac gland adenocarcinoma in the dog: 14 cases. J Small Anim Pract 1981; 22: 119-128 https://doi.org/10.1111/j.1748-5827.1981.tb00591.x
  3. Ross JT, Scavelli TD, Matthiesen DT et al. Adenocarcinoma of the apocrine glands of the anal sac in dogs: a review of 32 cases. J Am Anim Hosp Assoc 1991; 27: 349-355
  4. Meuten DJ, Cooper BJ, Capen CC et al. Hypercalcemia associated with an adenocarcinoma derived from the apocrine glands of the anal sac. Vet Pathol 1981; 18: 454-471
  5. Rosol TJ, Capen CC, Danks JA et al. Identification of parathyroid hormone-related protein in canine apocrine adenocarcinoma of the anal sac. Vet Pathol 1990; 27: 89-95 https://doi.org/10.1177/030098589002700203
  6. Grone A, Werkmeister JR, Steinmeyer CL et al. Parathyroid hormone-related protein in normal and neoplastic canine tissues: Immunohistochemical localization and biochemical extraction. Vet Pathol 1994; 31: 308-315 https://doi.org/10.1177/030098589403100303
  7. Williams LE, Gliatto JM, Dodge RK et al. Carcinoma of the apocrine glands of the anal sac in dogs: 113 dogs (1985-1995). J Am Vet Med Assoc 2003; 223: 825-831 https://doi.org/10.2460/javma.2003.223.825
  8. Bennett PF, DeNicola DB, Bonney P, Glickman NW, Knapp DW. Canine anal sac adenocarcinomas: clinical presentation and response to therapy. J Vet Intern Med 2002; 16(1): 100-104 https://doi.org/10.1111/j.1939-1676.2002.tb01613.x
  9. Bidur P, Min Soo K, Il Hong B, Mi Sun P et al. Retrospective study of canine cutaneous tumors in Korea. J Vet Sci 2007; 8: 229-236 https://doi.org/10.4142/jvs.2007.8.3.229
  10. S G Emms. Anal sac tumours of the dog and their response to cytoreductive surgery and chemotherapy. Aust Vet J 2005; 83: 340-343 https://doi.org/10.1111/j.1751-0813.2005.tb15626.x
  11. W Bertazzolo, S Comazzi, P Roccabianca, M Caniatti. Hypercalcaemia associated with a retroperitoneal apocrine gland adenocarcinoma in a dog. J Small Anim Pract. 2003; 44: 221-224 https://doi.org/10.1111/j.1748-5827.2003.tb00147.x
  12. Peter FB, Denis BD, Patty B, Nita WG, Deborah WK. Canine anal sac adenocarcinomas: clinical presentation and response to therapy. J Vet Intern Med. 2002; 16: 100-104 https://doi.org/10.1111/j.1939-1676.2002.tb01613.x
  13. Elemir S, Brian PW, Julie AY. A retrospective study of 44 canine apocrine sweat gland adenocarcinomas. Can Vet J 2003; 44: 38-42
  14. Morabito A, Bevilacqua P, Vitale S, Fanelli M, Gattuso D, Gasparini G. Clinical management of a case of recurrent apocrine gland carcinoma of the scalp: efficacy of a chemotherapy schedule with methotrexate and bleomycin. Tumori 2000; 86: 472-474
  15. Spugnini EP, Dotsinsky I, Mudrov N, Bufalini M, Giannini G, Citro G, Feroce F, Baldi A. Adjuvant electrochemotherapy for incompletely excised anal sac carcinoma in a dog. In Vivo 2008; 22: 47-49
  16. Howard PH, Marjorie RB, Kenita SR. Surgery of metastatic anal sac adenocarcinoma in five dogs. Vet Surg 2006; 35: 267-270.17 https://doi.org/10.1111/j.1532-950X.2006.00137.x
  17. Tozon N, Kodre V, Sersa G, Cemazar M. Effective treatment of perianal tumors in dogs with electrochemotherapy. Anticancer Res 2005; 25: 839-845
  18. Zeppetella G, Ribeiro MD. Opioids for the management of breakthrough (episodic) pain in cancer patients. Cochrane Database Syst Rev 2006; 25: CD004311
  19. Portenoy RK, Payne R, Coluzzi P, Raschko JW, Lyss A, Busch MA, Frigerio V, Ingham J, Loseth DB, Nordbrock E, Rhiner M. Oral transmucosal fentanyl citrate (OTFC) for the treatment of breakthrough pain in cancer patients: a controlled dose titration study. Pain 1999; 79: 303-312 https://doi.org/10.1016/S0304-3959(98)00179-1