Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Outbreak of Bovine Viral Diarrhea Virus in Korean Indigenous Calf

한우송아지에서 소 바이러스성 설사병 바이러스 발생

  • Song, Moo-Chan (Department of Animal Science, College of Ecology and Environmental Sciences, Kyungpook National University) ;
  • Choi, Kyoung-Seong (Department of Animal Science, College of Ecology and Environmental Sciences, Kyungpook National University)
  • 송무찬 (경북대학교 생태환경대학 축산학과) ;
  • 최경성 (경북대학교 생태환경대학 축산학과)
  • Published : 2009.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

A 25-day-old, Korean indigenous calf was presented with a 10 days history of respiratory disorders and bloody diarrhea, and died. This calf was extremely unthrifty compared to others and had evidence of chronic diarrhea based on matting of feces in the hair of the tail and perineum. Ecchymotic hemorrhages were observed on multiple organs at necropsy. Bovine viral diarrhea virus (BVDV) infection was identified by RT-PCR. The phylogenetic analysis showed that this case belonged to BVDV-2a subgroup and was related to highly pathogenic USA isolate 890 (U18059). This case provided evidence for circulation of BVDV-2 in Republic of Korea. The occurrence of BVDV-2 was also reconfirmed.

25일령의 한우송아지가 10일 간의 호흡기질환과 출혈성 설사의 병역을 나타내다가 폐사하였다. 이 송아지는 다른 송아지들과 비교해보았을 때 극도로 위축되어 있었다. 꼬리와 회음부의 분변 흔적은 만성설사가 지속되었음을 말해주었다. 부검시 다양한 기관(조직)에서 반상출혈이 관찰되었다. 역전사 중합효소연쇄반응에 의하여 소 바이러스성 설사병 바이러스가 진단되었다. 이 증례는 계통발생분석에서 BVDV-2a 그룹에 속하는데, 이것은 고병원성인 미국 균주890 (U18059)과 유사하다. 본 증례는 BVDV-2가 한국에서 유행하고 있다는 증거를 제공한다. 이를 통해 우리는 BVDV-2의 발생을 재확인하였다.

Keywords

References

  1. Carman S, van Dreumel T, Ridpath J, Hazlett M, Alves D, Dubovi E, Tremblay R, Bolin S, Godkin A, Anderson N. Severe acute bovine viral diarrhea in Ontario, 1993-1995. J Vet Diagn Invest 1998; 10: 27-35 https://doi.org/10.1177/104063879801000106
  2. Chi J, VanLeeuwen JA, Weersink A, Keefe GP. Direct production losses and treatment costs from bovine viral diarrhoea virus, bovine leukosis virus, Mycobacterium avium subspecies paratuberculosis, and Neospora caninum. Prev Vet Med 2002; 55: 137-153 https://doi.org/10.1016/S0167-5877(02)00094-6
  3. Flores EF, Ridpath JF, Weiblen R, Vogel FS, Gil LH. Phylogenetic analysis of Brazilian bovine viral diarrhea virus type 2 (BVDV-2) isolates: evidence for a subgenotype within BVDV-2. Virus Res 2002; 87: 51-60 https://doi.org/10.1016/S0168-1702(02)00080-1
  4. Fulton RW, Saliki JT, Confer AW, Burge LJ, d'Offay JM, Helman RG, Bolin SR, Ridpath JF, Payton ME. Bovine viral diarrhea virus cytopathic and noncytopathic biotypes and type 1 and 2 genotypes in diagnostic laboratory accessions: clinical and necropsy samples from cattle. J Vet Diagn Invest 2000; 12: 33-38 https://doi.org/10.1177/104063870001200106
  5. Hamers C, Lecomte C, Kulcsar G, Lambot M, Pastoret PP. Persistently infected cattle stabilise bovine viral diarrhea virus leading to herd specific strains. Vet Microbiol 1998; 61: 177-182 https://doi.org/10.1016/S0378-1135(98)00185-0
  6. Kelling CL, Steffen DJ, Cooper VL, Higuchi DS, Eskridge KM. Effect of infection with bovine viral diarrhea virus alone, bovine rotavirus alone, or concurrent infection with both on enteric disease in gnotobiotic neonatal calves. Am J Vet Res 2002; 63: 1179-1186 https://doi.org/10.2460/ajvr.2002.63.1179
  7. Moennig V, Liess B. Pathogenesis of intrauterine infections with bovine viral diarrhea virus. Vet Clin North Am Food Anim Pract 1995; 11: 477-487
  8. Nagai M, Sato M, Nagano H, Pang H, Kong X, Murakami T, Ozawa T, Akashi H. Nucleotide sequence homology to bovine viral diarrhea virus 2 (BVDV 2) in the 5' untranslated region of BVDVs from cattle with mucosal disease or persistent infection in Japan. Vet Microbiol 1998; 60: 271-276 https://doi.org/10.1016/S0378-1135(98)00158-8
  9. Page RD. TreeView: an application to display phylogenetic trees on personal computers. Comput Appl Biosci 1996; 12: 357-358
  10. Pellerin C, van den Hurk J, Lecomte J, Tussen P. Identification of a new group of bovine viral diarrhea virus strains associated with severe outbreaks and high mortalities. Virology 1994; 203: 260-268 https://doi.org/10.1006/viro.1994.1483
  11. Ridpath JF, Bolin SR, Dubovi EJ. Segregation of bovine viral diarrhea virus into genotypes. Virology 1994; 205: 66-74 https://doi.org/10.1006/viro.1994.1620
  12. Ridpath JF, Neill JD, Vilcek S, Dubovi EJ, Carman S. Multiple outbreaks of severe acute BVDV in North America occurring between 1993 and 1995 linked to the same BVDV2 strain. Vet Microbiol 2006; 114: 196-204 https://doi.org/10.1016/j.vetmic.2005.11.059
  13. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG. The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 1997; 25: 4876-4882 https://doi.org/10.1093/nar/25.24.4876
  14. Topliff CL, Kelling CL. Virulence markers in the 5' untranslated region of genotype 2 bovine viral diarrhea virus isolates. Virology 1998; 250: 164-172 https://doi.org/10.1006/viro.1998.9350
  15. Van Campen H, Vorpahl P, Huzurbazar S, Edwards J, Cavender J. A case report: evidence for type 2 bovine viral diarrhea virus (BVDV)-associated disease in beef herds vaccinated with a modified-live type 1 BVDV vaccine. J Vet Diagn Invest 2000; 12: 263-265 https://doi.org/10.1177/104063870001200312
  16. Vilcek S, Herring AJ, Herring JA, Nettleton PF, Lowings JP, Paton DJ. Pestiviruses isolated from pigs, cattle and sheep can be allocated into at least three genogroups using polymerase chain reaction and restriction endonuclease analysis. Arch Virol 1994; 136: 309-323 https://doi.org/10.1007/BF01321060
  17. Vilcek S, Drew TW, McGoldrick A, Paton DJ. Genetic typing of bovine pestiviruses from England and Wales. Vet Microbiol 1999; 69: 227-237 https://doi.org/10.1016/S0378-1135(99)00111-X
  18. Vilcek S, Paton DJ, Durkovic B, Strojny L, Ibata G, Moussa A, Loitsch A, Rossmanith W, Vega S, Scicluna MT, Paifi V. Bovine viral diarrhoea virus genotype 1 can be separated into at least eleven genetic groups. Arch Virol 2001; 146: 99-115 https://doi.org/10.1007/s007050170194
  19. Wolfmeyer A, Wolf G, Beer M, Strube W, Hehnen HR, Schmeer N, Kaaden OR. Genomic (5'UTR) and serological differences among German BVDV field isolates. Arch Virol 1997; 142: 2049-2057 https://doi.org/10.1007/s007050050222