Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Facial palsy as the presenting symptom of acute myeloid leukemia in children: Three cases with stem cell transplantations

안면마비로 초기 발현된 소아 급성골수성백혈병: 조혈모세포이식으로 성공적으로 치료한 3예

  • Baek, Hee Jo (Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Han, Dong Kyun (Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Kim, Young Ok (Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Choi, Ic Sun (Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Hwang, Tai Ju (Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Kook, Hoon (Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School)
  • 백희조 (전남대학교 의과대학 화순전남대학교병원 소아과학교실) ;
  • 한동균 (전남대학교 의과대학 화순전남대학교병원 소아과학교실) ;
  • 김영옥 (전남대학교 의과대학 화순전남대학교병원 소아과학교실) ;
  • 최익선 (전남대학교 의과대학 화순전남대학교병원 소아과학교실) ;
  • 황태주 (전남대학교 의과대학 화순전남대학교병원 소아과학교실) ;
  • 국훈 (전남대학교 의과대학 화순전남대학교병원 소아과학교실)
  • Received : 2009.12.22
  • Accepted : 2009.05.17
  • Published : 2009.06.15
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Abstract

Facial palsy as the presenting symptom of leukemia is very rare, especially in acute myeloid leukemia. A review of the medical literature identified reports on 8 children with AML who had facial paralysis as the presenting sign. Whole brain irradiation (WBI) has been applied in most cases. We present the cases of 3 such children. Achieving a remission without WBI, the patients underwent stem cell transplantations (SCTs). Two patients remain event-free 52 months and 62 months after allotransplants. Facial palsy was the harbinger of leukemic relapse in one case after autotransplant. This patient is disease-free 59 months after unrelated SCT rescue. Facial palsy persisted in 2 cases. Allogeneic SCT without WBI may be an effective therapy in patients presenting with facial palsy. A brief review of the literature is presented here.

안면 마비가 백혈병의 최초증상으로 발현되는 경우는 매우 드물고, 이들 대부분은 두개내 방사선 치료를 받는다. 이에 저자들을 백혈병의 최초증상으로 안면마비가 발현된 3례의 환자들을 보고하고자 한다. 3례 모두 두개내 방사선 치료없이 관해유도가 된 후 조혈모세포이식을 시행하였다. 2례는 동종이식 후 각각 52개월, 62개월까지 무사건 생존 중이고, 나머지 1례는 자가이식 후 재발의 최초증상으로 안면마비가 나타났고, 타인 조혈모세포이식 후 59개월째 무사건 생존 중이다. 2례에서 여전히 안면마비가 남아있긴 하지만, 두개내 방사선 치료 없이도 동종 조혈모세포이식으로 안면마비가 발현된 백혈병을 치료하여 이를 보고하고자 한다.

Keywords

References

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