Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Modeling the Cardiac Na+/H+ Exchanger Based on Major Experimental Findings

  • Cha, Chae Young (Biosimulation Project, Faculty of Bioinformatics, Ritsumeikan University) ;
  • Noma, Akinori (Biosimulation Project, Faculty of Bioinformatics, Ritsumeikan University)
  • Received : 2009.07.03
  • Accepted : 2009.07.06
  • Published : 2009.08.31
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Abstract

$Na^+-H^+$ exchanger (NHE) is the main acid extruder in cardiac myocytes. We review the experimental findings of ion-dependency of NHE activity, and the mathematical modeling developed so far. In spite of extensive investigation, many unsolved questions still remain. We consider that the precise description of NHE activity with mathematical models elucidates the roles of NHE in maintaining ionic homeostasis, especially under pathophysiological conditions.

Keywords

References

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