한국산업보건학회지 (Journal of Korean Society of Occupational and Environmental Hygiene)

  • 제19권2호
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  • Pages.127-138
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  • 2009
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  • 2384-132X(pISSN)
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  • 2289-0564(eISSN)
한국산업보건학회 (Korean Industrial Hygiene Association)
권호 표지

랫드에 주입된 국내산 암면의 호흡기 독성 및 생체내구성 평가

Domestic Rock Wool Toxicity Study on Respiratory System and Biopersistence Evaluation in Sprague-Dawely Rats

  • 정용현 (산업안전보건연구원 화학물질안전보건센터) ;
  • 한정희 (산업안전보건연구원 화학물질안전보건센터) ;
  • 강민구 (산업안전보건연구원 화학물질안전보건센터) ;
  • 이성배 (산업안전보건연구원 화학물질안전보건센터) ;
  • 김현영 (산업안전보건연구원 화학물질안전보건센터)
  • Chung, Yong Hyun (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Han, Jeong Hee (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Kang, Min Gu (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Lee, Sung Bae (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Kim, Hyeon Yeong (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute)
  • 투고 : 2009.01.06
  • 심사 : 2009.05.06
  • 발행 : 2009.06.30
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초록

Rock wool, a kind of asbestos substitutes, was analyzed for its physicochemical properties. After fivers of rock wool were instilled into rat lungs, These pathological changes were evaluated. In addition, the fibers in the lungs were counted and characterized after the lungs were treated for electron microscopical analysis. The lungs of rats showed pathological lesions such as granulomatous changes, but these lesions disappeared at 28 days groups after instilled rats. The rock wool fibers in the lungs decreased more 50 % after 28 days instilled into rat lungs. And rock wool showed early change in fiber compositions after 3 days compare with chrysotile showed after 7 days instilled into rat lungs. This study showed that the durability of rock wool in the lungs is more milder than chrysotile.

키워드

참고문헌

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