Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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노로바이러스에 의한 급성 위장관염의 임상양상 : 로타바이러스 장염과의 비교

Clinical features of acute noroviral gastroenteritis in children : comparison with rotaviral gastroenteritis

  • 황필주 (포천중문의과대학교 소아과학교실) ;
  • 곽지희 (포천중문의과대학교 소아과학교실) ;
  • 이택진 (포천중문의과대학교 소아과학교실) ;
  • 정수진 (포천중문의과대학교 소아과학교실)
  • Hwang, Pil-Joo (Department of Pediatrics, College of Medicine, Pochon CHA University) ;
  • Kwak, Ji Hee (Department of Pediatrics, College of Medicine, Pochon CHA University) ;
  • Lee, Taek Jin (Department of Pediatrics, College of Medicine, Pochon CHA University) ;
  • Jeong, Su Jin (Department of Pediatrics, College of Medicine, Pochon CHA University)
  • 투고 : 2008.09.16
  • 심사 : 2008.11.11
  • 발행 : 2009.04.15
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초록

목 적 : 본 연구에서는 장염증상으로 입원한 소아 중 노로바이러스에 의한 급성 위장관염의 임상양상을 알아보고자 하였다. 방 법 : 2006년 7월부터 2008년 6월까지 분당차병원 소아과에 급성 위장관염 증상으로 입원한 환아 중 대변 RT-PCR을 통해 노로바이러스 감염으로 진단되었던 22명의 임상 기록지를 후향적으로 분석하였다. 비교군은 로타바이러스 감염으로 진단되었던 45명의 환자로 하였다. 결 과 : 구토와 설사는 노로바이러스 군에서는 각각 19명(86.4 %), 21명(95.5%)에서 보였고, 로타바이러스 군 환아 모두에서 관찰되었다. 구토의 지속기간은 두 군간에 차이가 없었으나, 평균 구토횟수는 노로바이러스 군에서 더 많았다. 평균 설사횟수와 지속기간은 로타바이러스 군에서 더 높았다. Vesikari Scale은 두 군간에 차이가 없었으며, 발열 빈도와 지속기간 또한 두 군간 유의한 차이는 없었다. 두 군 모두 2세 미만의 소아가 대다수를 차지하였다. 결 론 : 노로바이러스 장염 증상의 전반적인 양상은 로타바이러스 감염과 비슷하였으나, 노로바이러스 감염에서 구토 증상이 더 심했고 로타바이러스 감염에서 설사가 더 심하고 오래 지속되었다. 앞으로 노로바이러스 감염에 대한 광범위한 역학조사 및 예방적 노력이 필요할 것이다.

Purpose : Our aim was to describe the clinical features of noroviral gastroenteritis in children. Methods : This study included 22 children with noroviral gastroenteritis, as confirmed by stool RT-PCR, who were admitted to Bundang CHA Hospital between July 2006 and June 2008. Their medical records were reviewed and compared with those of 45 children with rotaviral gastroenteritis. Results : In the norovirus group, 19 (86.4%) children showed vomiting and 21 (95.5%) children showed diarrhea, while all children in the rotaviral group showed both vomiting and diarrhea. The duration of vomiting was not different in the two groups, but mean episodes of vomiting/24 h were higher in the norovirus group than in the rotavirus group. The duration of diarrhea was longer and mean episodes of diarrhea/24 h were higher in the rotavirus group. The Vesikari Scale was not different in the two groups. Frequency and duration of fever did not show a significant difference. Most children in both groups were below 2 years of age. Conclusion : Clinical features of noroviral gastroenteritis were largely similar to those of rotaviral gastroenteritis, but vomiting was more severe in noroviral infection, and diarrhea was more severe and prolonged in rotaviral infection. With regard to noroviral infection, further epidemiologic investigations and preventive efforts are essential.

키워드

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