The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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Antinociceptive Effects of the Essential Oil of Ocimum Basilicum in Mice

백서에서 바질 에센셜 오일의 항통각 효과

  • Min, Sun Seek (Department of Physiology and Biophysics, College of Medicine, Eulji University) ;
  • Han, Seung Ho (Department of Physiology and Biophysics, College of Medicine, Eulji University) ;
  • Yee, Jaeyong (Department of Physiology and Biophysics, College of Medicine, Eulji University) ;
  • Kim, Chan (Department of Physiology and Biophysics, College of Medicine, Eulji University) ;
  • Seol, Geun Hee (Department of Basic Nursing Science, Korea University College of Nursing) ;
  • Im, Jae Hyeung (School of Humanities & Social Sience, Korea Advanced Institute of Science and Technology) ;
  • Kim, Hyung Tae (Department of Anesthesia and Pain Medicine, Presbyterian Medical Center) ;
  • Lee, Kyu Chang (Department of Anesthesiology and Pain Medicine, Chungju Hospital, School of Medicine, Konkuk University) ;
  • Kim, Hye Young (Department of Anesthesiology and Pain Medicine, Chungju Hospital, School of Medicine, Konkuk University) ;
  • Lee, Myeong Jong (Department of Anesthesiology and Pain Medicine, Chungju Hospital, School of Medicine, Konkuk University)
  • 민선식 (을지대학교 의과대학 생리학 및 생물리학교실) ;
  • 한승호 (을지대학교 의과대학 생리학 및 생물리학교실) ;
  • 이재용 (을지대학교 의과대학 생리학 및 생물리학교실) ;
  • 김찬 (을지대학교 의과대학 생리학 및 생물리학교실) ;
  • 설근희 (고려대학교 간호대학 기초간호학교실) ;
  • 임재형 (한국과학기술원 인문사회과학부) ;
  • 김형태 (전주 예수병원 마취통증의학과) ;
  • 이규창 (건국대학교 의학전문대학원 충주병원 마취통증의학교실) ;
  • 김혜영 (건국대학교 의학전문대학원 충주병원 마취통증의학교실) ;
  • 이명종 (건국대학교 의학전문대학원 충주병원 마취통증의학교실)
  • Received : 2009.10.01
  • Accepted : 2009.11.24
  • Published : 2009.12.01
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Abstract

Background: The essential oil of Ocimum basilicum (EOOB) has a pleasant aroma and is known to have antimicrobial and insecticidal activities. In addition, it is used as a pain reliever in folk medicine. However, there are few reports on the antinociceptive activities of EOOB. Methods: This study examined the antinociceptive effects of EOOB using formalin and a plantar test in mice. In the formalin test, EOOB (50 mg/kg, 100 mg/kg, 150 mg/kg) was administered intraperitoneally and the licking time of the mice was measured. In the plantar test, intraperitoneal EOOB (50 mg/kg, 100 mg/kg) was administered and the withdrawal latency was measured using the Hargreaves method. Results: In the formalin test, EOOB (50 mg/kg, IP) showed significant decreases in licking time in the second phase. On the other hand, in the plantar test, there were no significant effects in any of the groups examined. Conclusions: These results support the traditional use of EOOB for the treatment of painful conditions. However, there is a need for more research to determine the active chemical constituents and the precise mechanism.

Keywords

Acknowledgement

Supported by : 건국대학교

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