Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Changes in N-terminal pro-B-type natriuretic peptide in a neonate with symptomatic isolated left ventricular noncompaction

신생아기에 발견된 단독 심실 비치밀화증 1예에서 관찰된 NT pro-BNP의 변화

  • Song, Ji Hyeun (Department of Pediatrics, Keimyung University School of Medicine) ;
  • Kim, Yeo Hyang (Department of Pediatrics, Keimyung University School of Medicine) ;
  • Kim, Chun Soo (Department of Pediatrics, Keimyung University School of Medicine) ;
  • Lee, Sang Lak (Department of Pediatrics, Keimyung University School of Medicine) ;
  • Kwon, Tae Chan (Department of Pediatrics, Keimyung University School of Medicine)
  • 송지현 (계명대학교 의과대학 소아과학교실) ;
  • 김여향 (계명대학교 의과대학 소아과학교실) ;
  • 김천수 (계명대학교 의과대학 소아과학교실) ;
  • 이상락 (계명대학교 의과대학 소아과학교실) ;
  • 권태찬 (계명대학교 의과대학 소아과학교실)
  • Received : 2008.07.03
  • Accepted : 2008.10.08
  • Published : 2009.01.15
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Abstract

We describe here our experience with a neonate presenting with cyanosis, grunting, and cardiomegaly, who was diagnosed with isolated left ventricular noncompaction (IVNC) by echocardiography. The patient had high levels of N-terminal pro-B-type natriuretic peptide (NT pro-BNP) and symptoms of heart failure including poor feeding and tachypnea. During the period in which NT pro-BNP levels steadily increased, the patient suffered sudden cardiac arrest despite heart failure management. Following cardiopulmonary resuscitation, cardiac arrest was resolved, NT pro-BNP levels decreased, and all symptoms showed improvement. We consider that assessment of NT pro-BNP with cardiac functional analysis using echocardiography could help in the prediction of disease progress in IVNC.

저자들은 청색증과 끙끙거림, 심비대로 전원되어 심장 초음파 검사에서 좌심실에 발생한 단독 심실 비치밀화증을 가진 신생아 1예를 경험하였다. 환자에서 측정한 NT pro-BNP는 높았고, 수유 곤란과 빈호흡을 동반한 심부전 증상이 있었다. 심부전증에 대한 치료에도 불구하고 주기적으로 시행한 NT pro-BNP가 더 높아지면서 환자에게서 급성 심정지가 발생하였고, 심폐소생술 이후 NT pro-BNP가 다시 낮아지면서 심부전 등의 증상은 호전을 보였다. 심초음파 검사와 함께 NT pro-BNP를 주기적으로 검사해 보는 것이 병의 경과를 예측하는데 도움이 될 수 있을 것이다.

Keywords

References

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