Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Regulatory roles of NKT cells in Anaplasma phagocytophilum infection

  • Choi, Kyoung-Seong (College of Ecology and Environmental Sciences, Kyungpook National University) ;
  • Chae, Joon-Seok (College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University)
  • Accepted : 2009.05.28
  • Published : 2009.06.30
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Abstract

Human granulocytic anaplasmosis (HGA) is caused by the obligate intracellular bacterium Anaplasma (A.) phagocytophilum. Natural killer T (NKT) cells are key players in host defense against various microbial infections. We investigated the role of NKT cells in immune response to A. phagocytophilum infection using NKT-knockout ($J\alpha$18-/-) mice. $J\alpha$18-/- and wild-type (WT) mice were infected with low-passage A. phagocytophilum and assayed for hepatic histopathology and cytokine production during 7 days post-infection. Compared to WT controls, the infected $J\alpha$18 -/- mice had much less histopathologic lesions and less apoptosis through day 7, and lower concentrations of ${IFN\gamma}$ and IL- 12, but not of IL-10. This result suggests that NKT cells are major components in the pathogenesis of HGA.

Keywords

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