References
- Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215: 403-410
- Aparicio, J. F., P. Caffrey, A. F. A. Marsden, J. Staunton, and P. F. Leadlay. 1994. Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase. J. Biol. Chem. 269: 8524-8528
- Broadhurst, R. W., D. Nietlispach, M. P. Wheatcroft, P. F. Leadlay, and K. J. Weissman. 2003. The structure of docking domains in modular polyketide synthases. Chem. Biol. 10: 723-731 https://doi.org/10.1016/S1074-5521(03)00156-X
- Cheng, Y. Q., G. L. Tang, and B. Shen. 2003. Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 100: 3149-3154 https://doi.org/10.1073/pnas.0537286100
- Eddy, S. R. 1999. Profile hidden Markov models. Bioinformatics 14: 755-763 https://doi.org/10.1093/bioinformatics/14.9.755
- Floss, H. G. and T. W. Yu. 1999. Lessons from the rifamycin biosynthetic gene cluster. Curr. Opin. Chem. Biol. 3: 592- 597 https://doi.org/10.1016/S1367-5931(99)00014-9
- Gaitatzis, N., B. Silakowski, B. Kunze, G. Nordsiek, H. Blöcker, G. Höfle, and R. Müller. 2002. The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase. J. Biol. Chem. 277: 13082-13090 https://doi.org/10.1074/jbc.M111738200
- Ikeda, H., T. Nonomiya, M. Usami, T. Ohta, and S. Omura. 1999. Organization of the biosynthetic gene cluster for the polyketide antihelmintic macrolide avermectin in Streptomyces avermitilis. Proc. Natl. Acad. Sci. U.S.A. 96: 9509-9514 https://doi.org/10.1073/pnas.96.17.9509
- Jain, A. K., M. N. Murty, and P. J. Flynn. 1999. Data clustering: A review. ACM Computing Surveys 31: 264-323 https://doi.org/10.1145/331499.331504
- Kim, B. S., D. H. Sherman, and K. A. Reynolds. 2004. An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases. Protein Eng. Des. Sel. 17: 277-284 https://doi.org/10.1093/protein/gzh032
- Long, P. F., C. J. Wilkinson, C. P. Bisang, J. Cortes, N. Dunster, M. Oliynyk, et al. 2002. Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase. Mol. Microbiol. 43: 1215-1225 https://doi.org/10.1046/j.1365-2958.2002.02815.x
- Marchler-Bauer, A., A. R. Panchenko, B. A. Shoemaker, P. A. Thiessen, L. Y. Geer, and S. H. Bryant. 2002. CDD: A database of conserved domain alignments with links to domain threedimensional structure. Nucleic Acids Res. 30: 281-283 https://doi.org/10.1093/nar/30.1.281
- McDaniel, R., A. Thamchaipenet, C. Gustafsson, H. Fu, M. Betlach, and G. Ashley. 1999. Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel 'unnatural' natural products. Proc. Natl. Acad. Sci. U.S.A. 96: 1846-1851 https://doi.org/10.1073/pnas.96.5.1846
- McDaniel, R., C. M. Kao, S. J. Hwang, and C. Khosla. 1997. Engineered intermodular and intramodular polyketide synthase fusions. Chem. Biol. 4: 667-674 https://doi.org/10.1016/S1074-5521(97)90222-2
- Moore, B. S. and C. Hertweck. 2002. Biosynthesis and attachmentof novel bacterial polyketide synthase starter units. Nat. Prod.Rep. 19: 70-99 https://doi.org/10.1039/b003939j
- O'Hagan, D. 1993. Biosynthesis of fatty acid and polyketide metabolites. Nat. Prod. Rep. 10: 593-624 https://doi.org/10.1039/np9931000593
- Omura, S., H. Ikeda, J. Ishikawa, A. Hanamoto, C. Takahashi, M. Shinose, et al. 2001. Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites. Proc. Nat. Acad. Sci. U.S.A. 98: 12215-12220 https://doi.org/10.1073/pnas.211433198
- Pfeifer, B. A. and C. Khosla. 2001. Biosynthesis of polyketides in heterologous hosts. Microbiol. Mol. Biol. Rev. 65: 106-118 https://doi.org/10.1128/MMBR.65.1.106-118.2001
- Rawlings, B. J. 2001. Type I polyketide biosynthesis in bacteria(Part A - erythromycin biosynthesis). Nat. Prod. Rep. 18: 190-227 https://doi.org/10.1039/b009329g
- Rawlings, B. J. 2001. Type I polyketide biosynthesis in bacteria(Part B). Nat. Prod. Rep. 18: 231-281 https://doi.org/10.1039/b100191o
- Salzberg, S. L., A. L. Delcher, S. Kasif, and O. White. 1998. Microbial gene identification using interpolated Markov models. Nucleic Acids Res. 26: 544-548 https://doi.org/10.1093/nar/26.2.544
- Shen, B. and C. R. Hutchinson. 1996. Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase. Proc. Natl. Acad. Sci. U.S.A. 93: 6600-6604 https://doi.org/10.1073/pnas.93.13.6600
- Tae, H., E. B. Kong, and K. Park. 2007. ASMPKS: An analysis system for modular polyketide synthases. BMC Bioinformatics 8: 327 https://doi.org/10.1186/1471-2105-8-327
- Watanabe, K., C. C. Wang, C. N. Boddy, D. E. Cane, and C. Khosla. 2003. Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. J. Biol. Chem. 278: 42020-42026 https://doi.org/10.1074/jbc.M305339200
- Wiesmann, K. E., J. Cortes, M. J. Brown, A. L. Cutter, J. Staunton, and P. F. Leadlay. 1995. Polyketide synthesis in vitro on a modular polyketide synthase. Chem. Biol. 2: 583-589 https://doi.org/10.1016/1074-5521(95)90122-1
- Witkowski, A., V. S. Rangan, Z. I. Randhawa, C. M. Amy, and S. Smith. 1991. Structural organization of the multifunctional animal fatty-acid synthase. Eur. J. Biochem. 198: 571-579 https://doi.org/10.1111/j.1432-1033.1991.tb16052.x
- Wu, K., L. Chung, W. P. Revill, L. Katz, and C. D. Reeves. 2000. The FK520 gene cluster of Streptomycetes hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. Gene 251: 81-90 https://doi.org/10.1016/S0378-1119(00)00171-2
- Yadav, G., R. S. Gokhale, and D. Mohanty. 2003. SEARCHPKS: A program for detection and analysis of polyketide synthase domains. Nucleic Acids Res. 31: 3654-3658 https://doi.org/10.1093/nar/gkg607
- Zdobnov, E. M. and R. Apweiler. 2001. InterProScan - an integration platform for the signature-recognition methods in InterPro. Bioinformatics 17: 847-848 https://doi.org/10.1093/bioinformatics/17.9.847