Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Efficacy of Hydrogel Patch in Wound Rat Model

동물모델을 이용한 Hydrogel Patch의 상처치유개선 능력 평가

  • Published : 2009.02.20
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Abstract

Sodium polyacrylate based hydrogel patch was prepared and its wound healing efficacy in comparison with control groups was evaluated in thermal burn wound ($200^{\circ}C$, 10 sec burn) and excision wound rat model. Cytotoxicity of gamma irradiated (25 kGy) hydrogel patch was investigated in human fibroblasts and showed no significant cytotoxicity. Wound closure rates (H50%) in hydrogel patch group and BAND-$AID^{(R)}$ treated group were faster than that of control group (uncovered open wound). Hydrogel patch showed an enhancement in wound healing process.

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References

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Cited by

  1. Cytotoxicity Evaluation on Hydrogels for Medical Devices based on the International Organization for Standardization vol.39, pp.2, 2009, https://doi.org/10.4333/KPS.2009.39.2.127