한국간담췌외과학회지 (Annals of Hepato-Biliary-Pancreatic Surgery)

  • 제13권1호
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  • Pages.54-59
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  • 2009
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  • 2508-5778(pISSN)
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  • 2508-5859(eISSN)
한국간담췌외과학회 (The Korean Association of Hepato-Biliary-Pancreatic Surgery)
권호 표지

췌장의 선방세포악성종양 (Pancreatic Acinar Cell Carcinoma)

The Clinical Characteristics of Acinar Cell Carcinoma in the Pancreas

  • 김혜운 (연세대학교 의과대학 외과학 교실, 세브란스병원) ;
  • 류제규 (연세대학교 의과대학 외과학 교실, 세브란스병원) ;
  • 최새별 (고려대학교 의과대학 외과학교실, 구로병원) ;
  • 황호경 (연세대학교 의과대학 외과학 교실, 강남세브란스병원) ;
  • 김경식 (연세대학교 의과대학 외과학 교실, 세브란스병원) ;
  • 윤동섭 (연세대학교 의과대학 외과학 교실, 강남세브란스병원) ;
  • 이우정 (연세대학교 의과대학 외과학 교실, 세브란스병원)
  • Kim, Hye-Un (Dept. of surgery, Severance Hospital, Yonsei University College of Medicine) ;
  • Ryu, Je-Kyu (Dept. of surgery, Severance Hospital, Yonsei University College of Medicine) ;
  • Choi, Sae-Byeol (Dept. of Surgery, Guro Hospital, Korea University, College of Medicine) ;
  • Hwang, Ho-Kyoung (Dept. of surgery, Kangnam severance Hospital, Yonsei University College of Medicine) ;
  • Kim, Kyung-Sik (Dept. of surgery, Severance Hospital, Yonsei University College of Medicine) ;
  • Yoon, Dong-Sup (Dept. of surgery, Kangnam severance Hospital, Yonsei University College of Medicine) ;
  • Lee, Woo-Jung (Dept. of surgery, Severance Hospital, Yonsei University College of Medicine)
  • 발행 : 2009.03.25

⟨ 이전 논문 다음 논문 ⟩

초록

Acinar cell carcinoma (ACC) is a very rare type of pancreatic cancer that makes up less than 1% of all pancreatic cancers. The prognosis of ACC is very poor and the mean survival interval is only 18-19 months. The only effective treatment is currently early radical resection. Materials and methods: To determine ACC's clinical characteristics and the treatment efficacy, we conducted a retrospective chart review to study the clinical characteristics, laboratory findings, pathology and treatment responses of 10 ACC patients among 3042 pancreatic cancer patients who were diagnosed in Severance Hospital and Kangnam Severance Hospital of Yonsei University, College of Medicine from 1988.01.01 to 2008.12.31. Results: The 10 ACC patients were 6 males and 4 females. The mean age of the 10 ACC patients was 53.2 years. The most of the patients (7/10) complained the pain on the epigastric area and there was no jaundice in 8 patients (80%). Unfortunately, regional or distant metastases were founded in 8 patients (80%) at the time of the first diagnosis. The initial mean CA19-9 level was increased to 73.5 U/ml (range: 0.1~350.0 U/ml). Six of 10 patients underwent radical surgery and 4 of 10, including 1 with open and closure, were treated with conservative treatment. The median survival interval was 22.4 months with operative treatment and 1.5 months with conservative treatment. The median overall survival interval was 19.4 months. The median disease free survival was 17 months. The liver was the most common recurrent site (3 cases). Conclusions: An early radical resection is currently the best and only treatment for ACC, but in rare cases, post-operative adjuvant chemotherapy shows hopeful results and so this requires more study.

키워드

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